Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 22 studies | 30% ± 12% | |
| basal cell | 19 studies | 28% ± 13% | |
| ciliated cell | 19 studies | 41% ± 16% | |
| epithelial cell | 18 studies | 33% ± 19% | |
| astrocyte | 15 studies | 33% ± 15% | |
| pericyte | 14 studies | 19% ± 5% | |
| smooth muscle cell | 13 studies | 20% ± 4% | |
| oligodendrocyte precursor cell | 13 studies | 34% ± 14% | |
| fibroblast | 12 studies | 23% ± 6% | |
| GABAergic neuron | 11 studies | 46% ± 24% | |
| glutamatergic neuron | 11 studies | 52% ± 25% | |
| type I pneumocyte | 10 studies | 29% ± 8% | |
| club cell | 10 studies | 33% ± 14% | |
| secretory cell | 10 studies | 29% ± 12% | |
| type II pneumocyte | 10 studies | 39% ± 16% | |
| oligodendrocyte | 10 studies | 25% ± 12% | |
| dendritic cell | 9 studies | 32% ± 12% | |
| adipocyte | 9 studies | 21% ± 4% | |
| epithelial cell of proximal tubule | 8 studies | 27% ± 11% | |
| goblet cell | 8 studies | 27% ± 10% | |
| amacrine cell | 8 studies | 40% ± 14% | |
| conventional dendritic cell | 8 studies | 22% ± 7% | |
| kidney loop of Henle epithelial cell | 7 studies | 20% ± 1% | |
| myofibroblast cell | 7 studies | 20% ± 3% | |
| neuron | 7 studies | 39% ± 18% | |
| retinal cone cell | 7 studies | 52% ± 17% | |
| retinal rod cell | 7 studies | 36% ± 13% | |
| endothelial cell of vascular tree | 7 studies | 23% ± 3% | |
| connective tissue cell | 6 studies | 24% ± 5% | |
| vein endothelial cell | 6 studies | 19% ± 4% | |
| interneuron | 6 studies | 60% ± 17% | |
| macrophage | 6 studies | 24% ± 8% | |
| retinal ganglion cell | 6 studies | 44% ± 14% | |
| abnormal cell | 6 studies | 30% ± 13% | |
| retina horizontal cell | 6 studies | 28% ± 12% | |
| respiratory goblet cell | 5 studies | 38% ± 14% | |
| progenitor cell | 5 studies | 21% ± 4% | |
| kidney distal convoluted tubule epithelial cell | 5 studies | 24% ± 5% | |
| retinal bipolar neuron | 5 studies | 40% ± 16% | |
| mucus secreting cell | 5 studies | 29% ± 5% | |
| Mueller cell | 5 studies | 28% ± 9% | |
| pancreatic A cell | 4 studies | 42% ± 14% | |
| type B pancreatic cell | 4 studies | 43% ± 16% | |
| granule cell | 4 studies | 35% ± 8% | |
| plasma cell | 4 studies | 25% ± 8% | |
| cardiac muscle cell | 4 studies | 21% ± 4% | |
| mesothelial cell | 4 studies | 24% ± 15% | |
| OFF-bipolar cell | 4 studies | 40% ± 7% | |
| ON-bipolar cell | 4 studies | 30% ± 4% | |
| luminal hormone-sensing cell of mammary gland | 4 studies | 29% ± 4% | |
| hepatocyte | 4 studies | 63% ± 14% | |
| luminal cell of prostate epithelium | 4 studies | 39% ± 11% | |
| ionocyte | 3 studies | 23% ± 7% | |
| squamous epithelial cell | 3 studies | 36% ± 27% | |
| pancreatic D cell | 3 studies | 47% ± 18% | |
| cholangiocyte | 3 studies | 45% ± 20% | |
| endothelial cell of artery | 3 studies | 19% ± 2% | |
| GABAergic interneuron | 3 studies | 42% ± 5% | |
| microglial cell | 3 studies | 26% ± 9% | |
| monocyte | 3 studies | 22% ± 3% | |
| serous secreting cell | 3 studies | 24% ± 4% | |
| GABAergic amacrine cell | 3 studies | 47% ± 12% | |
| glycinergic amacrine cell | 3 studies | 37% ± 8% | |
| rod bipolar cell | 3 studies | 42% ± 6% | |
| acinar cell | 3 studies | 38% ± 22% | |
| erythroblast | 3 studies | 30% ± 12% | |
| pancreatic ductal cell | 3 studies | 50% ± 12% | |
| megakaryocyte-erythroid progenitor cell | 3 studies | 28% ± 12% | |
| enterocyte | 3 studies | 18% ± 3% | |
| intestinal crypt stem cell | 3 studies | 23% ± 4% | |
| renal principal cell | 3 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1342.00 | 1445 / 1445 | 100% | 16.02 | 183 / 183 |
| prostate | 100% | 1821.64 | 245 / 245 | 100% | 12.80 | 502 / 502 |
| brain | 100% | 2085.67 | 2642 / 2642 | 100% | 13.80 | 704 / 705 |
| lung | 100% | 1697.89 | 577 / 578 | 100% | 20.52 | 1155 / 1155 |
| ovary | 100% | 1668.55 | 180 / 180 | 99% | 20.60 | 427 / 430 |
| pancreas | 100% | 1668.26 | 328 / 328 | 99% | 10.76 | 176 / 178 |
| breast | 100% | 1429.64 | 459 / 459 | 99% | 12.52 | 1104 / 1118 |
| kidney | 100% | 2134.02 | 89 / 89 | 98% | 11.71 | 887 / 901 |
| thymus | 100% | 1952.85 | 653 / 653 | 98% | 11.74 | 594 / 605 |
| stomach | 100% | 1384.40 | 359 / 359 | 98% | 11.60 | 280 / 286 |
| bladder | 100% | 1339.57 | 21 / 21 | 98% | 10.44 | 493 / 504 |
| uterus | 100% | 1212.69 | 170 / 170 | 98% | 16.05 | 448 / 459 |
| intestine | 100% | 1660.79 | 966 / 966 | 98% | 10.21 | 514 / 527 |
| liver | 100% | 1577.20 | 226 / 226 | 95% | 8.83 | 385 / 406 |
| adrenal gland | 100% | 2861.83 | 258 / 258 | 94% | 7.81 | 217 / 230 |
| skin | 100% | 1444.33 | 1809 / 1809 | 91% | 8.08 | 431 / 472 |
| spleen | 100% | 1000.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 17.43 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.13 | 1 / 1 |
| adipose | 100% | 1109.36 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1113.22 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 95% | 599.41 | 816 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 65% | 532.81 | 608 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 59% | 3.47 | 47 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 59% | 2.87 | 17 / 29 |
| muscle | 37% | 130.39 | 299 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0043507 | Biological process | positive regulation of JUN kinase activity |
| GO_0007254 | Biological process | JNK cascade |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0045773 | Biological process | positive regulation of axon extension |
| GO_1905492 | Biological process | positive regulation of branching morphogenesis of a nerve |
| GO_0051403 | Biological process | stress-activated MAPK cascade |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_0150012 | Biological process | positive regulation of neuron projection arborization |
| GO_0014042 | Biological process | positive regulation of neuron maturation |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0106137 | Molecular function | IkappaB kinase complex binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
| GO_0004709 | Molecular function | MAP kinase kinase kinase activity |
| GO_0004706 | Molecular function | JUN kinase kinase kinase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MAP3K13 |
| Protein name | Mitogen-activated protein kinase kinase kinase 13 Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK) |
| Synonyms | LZK |
| Description | FUNCTION: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. . |
| Accessions | H7C459 ENST00000424227.5 [O43283-1] C9J4W2 ENST00000443863.5 [O43283-4] F8WF41 C9IYH2 ENST00000420577.1 ENST00000438053.5 [O43283-3] ENST00000438798.1 ENST00000455188.5 ENST00000439882.1 ENST00000447637.1 ENST00000265026.8 [O43283-1] ENST00000446828.5 [O43283-5] ENST00000433092.5 [O43283-6] ENST00000454237.1 ENST00000448876.5 O43283 ENST00000428617.1 C9JP65 |