MAP3K13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0007254Biological processJNK cascade
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0045773Biological processpositive regulation of axon extension
GO_1905492Biological processpositive regulation of branching morphogenesis of a nerve
GO_0051403Biological processstress-activated MAPK cascade
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0150012Biological processpositive regulation of neuron projection arborization
GO_0014042Biological processpositive regulation of neuron maturation
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0106137Molecular functionIkappaB kinase complex binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0004706Molecular functionJUN kinase kinase kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP3K13
Protein nameMitogen-activated protein kinase kinase kinase 13
Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK)
SynonymsLZK
DescriptionFUNCTION: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. .

AccessionsH7C459
ENST00000424227.5 [O43283-1]
C9J4W2
ENST00000443863.5 [O43283-4]
F8WF41
C9IYH2
ENST00000420577.1
ENST00000438053.5 [O43283-3]
ENST00000438798.1
ENST00000455188.5
ENST00000439882.1
ENST00000447637.1
ENST00000265026.8 [O43283-1]
ENST00000446828.5 [O43283-5]
ENST00000433092.5 [O43283-6]
ENST00000454237.1
ENST00000448876.5
O43283
ENST00000428617.1
C9JP65