LAT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043303Biological processmast cell degranulation
GO_0002250Biological processadaptive immune response
GO_0050853Biological processB cell receptor signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0019722Biological processcalcium-mediated signaling
GO_0042113Biological processB cell activation
GO_0045121Cellular componentmembrane raft
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0042169Molecular functionSH2 domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLAT2
Protein nameLinker for activation of T cells family member 2
Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein)
SynonymsWBS15
LAB
HSPC046
WBSCR5
WBSCR15
NTAL
DescriptionFUNCTION: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. .

AccessionsENST00000361082.7
ENST00000275635.11 [Q9GZY6-1]
ENST00000470709.1
C9JXP0
C9JA24
ENST00000465116.5
F8W947
Q9GZY6
ENST00000488266.5 [Q9GZY6-2]
ENST00000475494.5
C9JDY7
ENST00000398475.5 [Q9GZY6-1]
ENST00000460943.6 [Q9GZY6-1]
ENST00000344995.9 [Q9GZY6-1]