Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 34 studies | 30% ± 10% | |
natural killer cell | 30 studies | 25% ± 6% | |
mast cell | 20 studies | 29% ± 8% | |
classical monocyte | 20 studies | 29% ± 14% | |
conventional dendritic cell | 18 studies | 31% ± 19% | |
naive B cell | 18 studies | 33% ± 10% | |
memory B cell | 17 studies | 32% ± 8% | |
CD16-positive, CD56-dim natural killer cell, human | 15 studies | 28% ± 7% | |
monocyte | 15 studies | 27% ± 8% | |
macrophage | 14 studies | 25% ± 8% | |
CD16-negative, CD56-bright natural killer cell, human | 12 studies | 30% ± 13% | |
non-classical monocyte | 10 studies | 25% ± 9% | |
microglial cell | 10 studies | 33% ± 13% | |
dendritic cell | 10 studies | 30% ± 13% | |
myeloid cell | 8 studies | 27% ± 12% | |
precursor B cell | 7 studies | 48% ± 18% | |
immature B cell | 6 studies | 52% ± 20% | |
hematopoietic precursor cell | 5 studies | 46% ± 25% | |
mature NK T cell | 5 studies | 29% ± 7% | |
gamma-delta T cell | 5 studies | 25% ± 4% | |
pro-B cell | 5 studies | 54% ± 12% | |
leukocyte | 4 studies | 26% ± 8% | |
hematopoietic stem cell | 4 studies | 30% ± 12% | |
plasma cell | 4 studies | 24% ± 5% | |
innate lymphoid cell | 4 studies | 23% ± 4% | |
plasmablast | 3 studies | 42% ± 29% | |
common myeloid progenitor | 3 studies | 31% ± 18% | |
germinal center B cell | 3 studies | 47% ± 9% | |
mononuclear phagocyte | 3 studies | 29% ± 15% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 8 studies | 29% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 1954.00 | 578 / 578 | 98% | 11.34 | 1132 / 1155 |
prostate | 97% | 678.42 | 237 / 245 | 100% | 13.45 | 502 / 502 |
brain | 84% | 540.26 | 2224 / 2642 | 99% | 20.36 | 699 / 705 |
intestine | 89% | 623.72 | 863 / 966 | 92% | 7.11 | 483 / 527 |
breast | 80% | 290.38 | 369 / 459 | 99% | 10.72 | 1105 / 1118 |
bladder | 95% | 568.00 | 20 / 21 | 80% | 7.33 | 404 / 504 |
liver | 99% | 446.76 | 224 / 226 | 73% | 6.72 | 297 / 406 |
uterus | 75% | 250.64 | 128 / 170 | 95% | 6.80 | 435 / 459 |
stomach | 75% | 269.28 | 271 / 359 | 92% | 7.21 | 262 / 286 |
thymus | 74% | 306.92 | 484 / 653 | 92% | 7.68 | 558 / 605 |
esophagus | 79% | 298.35 | 1142 / 1445 | 86% | 4.94 | 158 / 183 |
adrenal gland | 97% | 528.94 | 250 / 258 | 66% | 3.16 | 151 / 230 |
kidney | 65% | 300.52 | 58 / 89 | 93% | 10.67 | 842 / 901 |
pancreas | 47% | 169.64 | 154 / 328 | 97% | 12.48 | 172 / 178 |
ovary | 38% | 98.84 | 68 / 180 | 89% | 6.45 | 381 / 430 |
skin | 37% | 104.35 | 667 / 1809 | 87% | 8.70 | 410 / 472 |
lymph node | 0% | 0 | 0 / 0 | 100% | 128.30 | 29 / 29 |
peripheral blood | 100% | 16213.33 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 5468.79 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 9.77 | 43 / 45 |
adipose | 94% | 500.36 | 1128 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 75% | 395.06 | 999 / 1335 | 0% | 0 | 0 / 0 |
muscle | 53% | 201.30 | 427 / 803 | 0% | 0 | 0 / 0 |
heart | 49% | 151.34 | 424 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 30% | 1.35 | 24 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0043303 | Biological process | mast cell degranulation |
GO_0002250 | Biological process | adaptive immune response |
GO_0050853 | Biological process | B cell receptor signaling pathway |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0019722 | Biological process | calcium-mediated signaling |
GO_0042113 | Biological process | B cell activation |
GO_0045121 | Cellular component | membrane raft |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005886 | Cellular component | plasma membrane |
GO_0042169 | Molecular function | SH2 domain binding |
GO_0005515 | Molecular function | protein binding |
Gene name | LAT2 |
Protein name | Linker for activation of T cells family member 2 Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein) |
Synonyms | WBS15 LAB HSPC046 WBSCR5 WBSCR15 NTAL |
Description | FUNCTION: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. . |
Accessions | ENST00000361082.7 ENST00000275635.11 [Q9GZY6-1] ENST00000470709.1 C9JXP0 C9JA24 ENST00000465116.5 F8W947 Q9GZY6 ENST00000488266.5 [Q9GZY6-2] ENST00000475494.5 C9JDY7 ENST00000398475.5 [Q9GZY6-1] ENST00000460943.6 [Q9GZY6-1] ENST00000344995.9 [Q9GZY6-1] |