LAPTM4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905166Biological processnegative regulation of lysosomal protein catabolic process
GO_0097213Biological processregulation of lysosomal membrane permeability
GO_0032911Biological processnegative regulation of transforming growth factor beta1 production
GO_0032509Biological processendosome transport via multivesicular body sorting pathway
GO_0007032Biological processendosome organization
GO_1905671Biological processregulation of lysosome organization
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0005764Cellular componentlysosome
GO_0097487Cellular componentmultivesicular body, internal vesicle
GO_0042995Cellular componentcell projection
GO_0005768Cellular componentendosome
GO_0032585Cellular componentmultivesicular body membrane
GO_0005765Cellular componentlysosomal membrane
GO_0097001Molecular functionceramide binding
GO_0019900Molecular functionkinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_1902936Molecular functionphosphatidylinositol bisphosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLAPTM4B
Protein nameLAPTM4B (Lysosome-associated protein transmembrane 4 beta)
Lysosomal protein transmembrane 4 beta
Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta)
SynonymsPSEC0001
DescriptionFUNCTION: Required for optimal lysosomal function . Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation . Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation . Plays a role as negative regulator of TGFB1 production in regulatory T cells . Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways . .

AccessionsENST00000517924.5
ENST00000521545.7 [Q86VI4-2]
H0YBN1
ENST00000445593.6 [Q86VI4-3]
ENST00000619747.1 [Q86VI4-3]
Q86VI4
Q86SJ0