IVNS1ABP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	30 studies	24% ± 6%	Explore
macrophage	28 studies	26% ± 9%	Explore
classical monocyte	23 studies	27% ± 7%	Explore
endothelial cell	21 studies	27% ± 10%	Explore
CD4-positive, alpha-beta T cell	18 studies	20% ± 5%	Explore
monocyte	17 studies	27% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	28% ± 9%	Explore
regulatory T cell	15 studies	24% ± 7%	Explore
T cell	14 studies	26% ± 15%	Explore
CD8-positive, alpha-beta T cell	14 studies	20% ± 6%	Explore
basal cell	13 studies	26% ± 19%	Explore
conventional dendritic cell	12 studies	22% ± 6%	Explore
mucosal invariant T cell	12 studies	24% ± 9%	Explore
mature NK T cell	11 studies	21% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	23% ± 7%	Explore
gamma-delta T cell	11 studies	25% ± 9%	Explore
dendritic cell	9 studies	28% ± 11%	Explore
neutrophil	9 studies	47% ± 11%	Explore
epithelial cell	9 studies	37% ± 17%	Explore
kidney loop of Henle epithelial cell	8 studies	41% ± 12%	Explore
myeloid cell	8 studies	31% ± 8%	Explore
endothelial cell of vascular tree	8 studies	24% ± 6%	Explore
oligodendrocyte	8 studies	25% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	24% ± 5%	Explore
non-classical monocyte	6 studies	20% ± 3%	Explore
mononuclear phagocyte	6 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
goblet cell	6 studies	26% ± 9%	Explore
microglial cell	6 studies	24% ± 6%	Explore
lymphocyte	6 studies	23% ± 11%	Explore
ciliated cell	6 studies	31% ± 16%	Explore
capillary endothelial cell	6 studies	27% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	23% ± 7%	Explore
leukocyte	5 studies	22% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	64% ± 11%	Explore
innate lymphoid cell	5 studies	23% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	18% ± 1%	Explore
abnormal cell	4 studies	24% ± 6%	Explore
naive B cell	4 studies	19% ± 4%	Explore
T follicular helper cell	4 studies	23% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	23% ± 8%	Explore
GABAergic neuron	4 studies	29% ± 7%	Explore
glutamatergic neuron	4 studies	31% ± 9%	Explore
enterocyte	4 studies	16% ± 1%	Explore
renal principal cell	4 studies	44% ± 9%	Explore
duct epithelial cell	3 studies	20% ± 1%	Explore
secretory cell	3 studies	36% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
pericyte	3 studies	42% ± 18%	Explore
tissue-resident macrophage	3 studies	26% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore
CD4-positive helper T cell	3 studies	30% ± 12%	Explore
fibroblast	3 studies	19% ± 1%	Explore
vein endothelial cell	3 studies	22% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	27% ± 3%	Explore
enteroendocrine cell	3 studies	19% ± 2%	Explore
alveolar macrophage	3 studies	32% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 6%	Explore
T-helper 17 cell	3 studies	21% ± 4%	Explore
interneuron	3 studies	26% ± 9%	Explore
neuron	3 studies	26% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
kidney	8 studies	24% ± 5%	Explore
lung	6 studies	23% ± 8%	Explore
peripheral blood	6 studies	21% ± 3%	Explore
brain	6 studies	30% ± 7%	Explore
liver	5 studies	25% ± 8%	Explore
breast	3 studies	19% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
uterus	100%	6683.92	170 / 170	100%	84.08	459 / 459
esophagus	100%	5931.82	1441 / 1445	100%	87.39	183 / 183
lung	100%	12499.89	577 / 578	100%	75.96	1153 / 1155
bladder	100%	6966.43	21 / 21	100%	67.13	502 / 504
breast	100%	11408.46	459 / 459	99%	58.95	1112 / 1118
kidney	100%	18857.79	89 / 89	99%	155.30	896 / 901
intestine	100%	7147.01	965 / 966	99%	66.33	524 / 527
stomach	100%	8281.73	359 / 359	99%	60.64	284 / 286
thymus	100%	11622.50	653 / 653	99%	54.48	600 / 605
ovary	99%	7005.73	179 / 180	100%	49.20	428 / 430
pancreas	100%	5207.98	327 / 328	99%	77.50	176 / 178
skin	99%	10715.33	1796 / 1809	99%	128.81	468 / 472
brain	98%	5052.53	2588 / 2642	100%	67.82	705 / 705
prostate	100%	9730.80	245 / 245	97%	37.87	486 / 502
adrenal gland	100%	4834.54	258 / 258	91%	38.04	210 / 230
liver	97%	4193.13	219 / 226	78%	31.72	316 / 406
spleen	100%	10220.90	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	64.51	45 / 45
ureter	0%	0	0 / 0	100%	31.14	1 / 1
adipose	100%	12574.58	1203 / 1204	0%	0	0 / 0
peripheral blood	99%	17722.02	924 / 929	0%	0	0 / 0
blood vessel	99%	5167.45	1318 / 1335	0%	0	0 / 0
muscle	98%	4350.82	786 / 803	0%	0	0 / 0
heart	97%	5516.76	835 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	50.45	28 / 29
eye	0%	0	0 / 0	74%	26.34	59 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009615	Biological process	response to virus
GO_0097193	Biological process	intrinsic apoptotic signaling pathway
GO_2001243	Biological process	negative regulation of intrinsic apoptotic signaling pathway
GO_0008380	Biological process	RNA splicing
GO_0006383	Biological process	transcription by RNA polymerase III
GO_0031397	Biological process	negative regulation of protein ubiquitination
GO_0005856	Cellular component	cytoskeleton
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005681	Cellular component	spliceosomal complex
GO_0005667	Cellular component	transcription regulator complex
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IVNS1ABP
Protein name	Influenza virus NS1A binding protein Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39)
Synonyms	NS1 KLHL39 KIAA0850 NS1BP FLARA3 HSPC068 ARA3
Description	FUNCTION: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription . In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors . Inhibits pre-mRNA splicing (in vitro) . .; FUNCTION: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. .
Accessions	ENST00000422754.1 ENST00000367497.1 ENST00000367498.8 X6R674 H0Y5Y2 Q9Y6Y0

IVNS1ABP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review