Name | Number of supported studies | Average coverage | |
---|---|---|---|
classical monocyte | 17 studies | 31% ± 12% | |
conventional dendritic cell | 16 studies | 33% ± 14% | |
ciliated cell | 13 studies | 30% ± 10% | |
non-classical monocyte | 12 studies | 30% ± 12% | |
monocyte | 12 studies | 25% ± 8% | |
platelet | 9 studies | 34% ± 12% | |
macrophage | 9 studies | 21% ± 4% | |
dendritic cell | 8 studies | 38% ± 15% | |
gamma-delta T cell | 8 studies | 19% ± 3% | |
CD8-positive, alpha-beta T cell | 7 studies | 19% ± 3% | |
natural killer cell | 7 studies | 20% ± 5% | |
CD16-positive, CD56-dim natural killer cell, human | 6 studies | 19% ± 2% | |
regulatory T cell | 6 studies | 19% ± 3% | |
effector memory CD8-positive, alpha-beta T cell | 5 studies | 19% ± 2% | |
exhausted T cell | 4 studies | 22% ± 6% | |
megakaryocyte | 4 studies | 32% ± 13% | |
effector CD8-positive, alpha-beta T cell | 4 studies | 19% ± 2% | |
hematopoietic stem cell | 4 studies | 28% ± 15% | |
mononuclear phagocyte | 3 studies | 29% ± 11% | |
pericyte | 3 studies | 22% ± 2% | |
myeloid cell | 3 studies | 27% ± 5% | |
effector CD4-positive, alpha-beta T cell | 3 studies | 21% ± 1% | |
double negative thymocyte | 3 studies | 20% ± 1% | |
microglial cell | 3 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 12 studies | 21% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 99% | 934.12 | 179 / 180 | 95% | 6.27 | 407 / 430 |
thymus | 100% | 631.34 | 650 / 653 | 91% | 4.80 | 549 / 605 |
lung | 100% | 1741.74 | 577 / 578 | 88% | 6.38 | 1018 / 1155 |
breast | 93% | 552.33 | 426 / 459 | 92% | 9.77 | 1030 / 1118 |
uterus | 100% | 872.96 | 170 / 170 | 72% | 4.19 | 332 / 459 |
esophagus | 98% | 1428.61 | 1414 / 1445 | 68% | 4.26 | 125 / 183 |
bladder | 100% | 763.00 | 21 / 21 | 60% | 3.59 | 303 / 504 |
kidney | 75% | 306.83 | 67 / 89 | 79% | 4.32 | 712 / 901 |
skin | 97% | 1065.91 | 1759 / 1809 | 55% | 2.78 | 260 / 472 |
prostate | 98% | 691.69 | 239 / 245 | 51% | 1.84 | 257 / 502 |
stomach | 87% | 658.21 | 313 / 359 | 61% | 3.10 | 175 / 286 |
intestine | 100% | 1461.31 | 964 / 966 | 40% | 1.68 | 213 / 527 |
brain | 85% | 346.34 | 2248 / 2642 | 48% | 2.04 | 339 / 705 |
adrenal gland | 98% | 1193.52 | 253 / 258 | 33% | 1.52 | 77 / 230 |
spleen | 100% | 1098.85 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 2181.59 | 923 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 1210.39 | 1325 / 1335 | 0% | 0 | 0 / 0 |
adipose | 96% | 661.29 | 1160 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 8.49 | 25 / 29 |
pancreas | 8% | 24.55 | 26 / 328 | 77% | 3.79 | 137 / 178 |
tonsil | 0% | 0 | 0 / 0 | 78% | 3.81 | 35 / 45 |
eye | 0% | 0 | 0 / 0 | 43% | 1.48 | 34 / 80 |
heart | 31% | 96.41 | 269 / 861 | 0% | 0 | 0 / 0 |
liver | 6% | 15.05 | 14 / 226 | 6% | 0.18 | 23 / 406 |
muscle | 3% | 7.20 | 23 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0030148 | Biological process | sphingolipid biosynthetic process |
GO_0042761 | Biological process | very long-chain fatty acid biosynthetic process |
GO_0030497 | Biological process | fatty acid elongation |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0019899 | Molecular function | enzyme binding |
GO_0005515 | Molecular function | protein binding |
GO_0018812 | Molecular function | 3-hydroxyacyl-CoA dehydratase activity |
GO_0102158 | Molecular function | very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity |
Gene name | HACD4 |
Protein name | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 4) (HACD4) (Protein-tyrosine phosphatase-like A domain-containing protein 2) |
Synonyms | PTPLAD2 |
Description | FUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. . |
Accessions | Q5VWC8 ENST00000495827.3 |