HACD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030148Biological processsphingolipid biosynthetic process
GO_0042761Biological processvery long-chain fatty acid biosynthetic process
GO_0030497Biological processfatty acid elongation
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0019899Molecular functionenzyme binding
GO_0005515Molecular functionprotein binding
GO_0018812Molecular function3-hydroxyacyl-CoA dehydratase activity
GO_0102158Molecular functionvery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity

IV. Literature review

[source]
Gene nameHACD4
Protein nameVery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 4) (HACD4) (Protein-tyrosine phosphatase-like A domain-containing protein 2)
SynonymsPTPLAD2
DescriptionFUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. .

AccessionsQ5VWC8
ENST00000495827.3