GRAMD1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006914Biological processautophagy
GO_0071397Biological processcellular response to cholesterol
GO_0032366Biological processintracellular sterol transport
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0044232Cellular componentorganelle membrane contact site
GO_0140268Cellular componentendoplasmic reticulum-plasma membrane contact site
GO_0005776Cellular componentautophagosome
GO_0015485Molecular functioncholesterol binding
GO_0005515Molecular functionprotein binding
GO_0120020Molecular functioncholesterol transfer activity

IV. Literature review

[source]
Gene nameGRAMD1A
Protein nameGRAM domain containing 1A
Protein Aster-A (GRAM domain-containing protein 1A)
SynonymsKIAA1533
DescriptionFUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome . This function in autophagy requires its cholesterol-transfer activity . .

AccessionsENST00000600231.5
M0QZ12
ENST00000680623.1 [Q96CP6-3]
Q96CP6
M0R0J9
ENST00000599564.5
ENST00000317991.10 [Q96CP6-1]
ENST00000424536.2
S4R3I2
ENST00000411896.6 [Q96CP6-2]