GPM6A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009617Biological processresponse to bacterium
GO_0031175Biological processneuron projection development
GO_0003407Biological processneural retina development
GO_0001764Biological processneuron migration
GO_0048812Biological processneuron projection morphogenesis
GO_0050807Biological processregulation of synapse organization
GO_0051491Biological processpositive regulation of filopodium assembly
GO_0007416Biological processsynapse assembly
GO_0048863Biological processstem cell differentiation
GO_0070588Biological processcalcium ion transmembrane transport
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0048787Cellular componentpresynaptic active zone membrane
GO_1903561Cellular componentextracellular vesicle
GO_0070062Cellular componentextracellular exosome
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0030175Cellular componentfilopodium
GO_0044295Cellular componentaxonal growth cone
GO_0098688Cellular componentparallel fiber to Purkinje cell synapse
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameGPM6A
Protein nameNeuronal membrane glycoprotein M6-a
Glycoprotein M6A
Neuronal membrane glycoprotein M6-a (M6a)
SynonymsM6A
DescriptionFUNCTION: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. .

AccessionsENST00000505375.5
ENST00000509865.5
D6RFZ3
D6RD95
ENST00000503563.1
ENST00000502754.5
D6R9T7
ENST00000503397.5
ENST00000506894.5 [P51674-3]
ENST00000507520.5
ENST00000513667.5
ENST00000280187.11 [P51674-1]
ENST00000512897.5
D6RBM6
ENST00000505304.1
D6RBH3
A0A1D5RMS2
D6RD71
D6RIF4
ENST00000393658.7 [P51674-1]
D6RDV7
Q49AH3
ENST00000507540.1
Q86YB0
ENST00000512509.5
ENST00000513365.1
ENST00000512610.5
D6RB41
ENST00000505561.5
P51674
D6RAE4
D6R9D2
D6RFY0
ENST00000515090.5 [P51674-2]
D6REJ8