FTO report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016180Biological processsnRNA processing
GO_0090335Biological processregulation of brown fat cell differentiation
GO_0061157Biological processmRNA destabilization
GO_0040014Biological processregulation of multicellular organism growth
GO_0070350Biological processregulation of white fat cell proliferation
GO_0006307Biological processDNA alkylation repair
GO_0044065Biological processregulation of respiratory system process
GO_0010883Biological processregulation of lipid storage
GO_0042245Biological processRNA repair
GO_0060612Biological processadipose tissue development
GO_0001659Biological processtemperature homeostasis
GO_0005886Cellular componentplasma membrane
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0035516Molecular functionbroad specificity oxidative DNA demethylase activity
GO_0016740Molecular functiontransferase activity
GO_0008198Molecular functionferrous iron binding
GO_0035515Molecular functionoxidative RNA demethylase activity
GO_1990931Molecular functionmRNA N6-methyladenosine dioxygenase activity
GO_1990984Molecular functiontRNA demethylase activity

IV. Literature review

[source]
Gene nameFTO
Protein nameFTO alpha-ketoglutarate dependent dioxygenase
Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-)
Alpha-ketoglutarate-dependent dioxygenase FTO (EC 1.14.11.53) (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (mRNA N(6)-methyladenosine demethylase FTO) (tRNA N1-methyl adenine demethylase FTO)
SynonymsKIAA1752
DescriptionFUNCTION: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis . Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes . M6A demethylation by FTO affects mRNA expression and stability . Also able to demethylate m6A in U6 small nuclear RNA (snRNA) . Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA . Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping . Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs . Has no activity towards 1-methylguanine . Has no detectable activity towards double-stranded DNA . Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine . Ability to repair alkylated DNA and RNA is however unsure in vivo . Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation . Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells . Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression . .

AccessionsX6R3I0
A0A1B0GVH5
ENST00000563011.2
ENST00000463855.1 [Q9C0B1-2]
A0A1B0GTC3
ENST00000637001.1
ENST00000637562.1
A0A1B0GU26
ENST00000612285.2
A0A1B0GTY5
ENST00000460382.5 [Q9C0B1-4]
F8WCB8
ENST00000637049.1
A0A1B0GTY1
A0A1B0GTC5
A0A1B0GUY7
Q9C0B1
A0A1B0GUC3
ENST00000464071.1
A0A1B0GTI3
ENST00000636218.1
ENST00000268349.7
ENST00000431610.6 [Q9C0B1-4]
A0A1B0GTZ8
ENST00000636992.1
ENST00000637969.1
ENST00000636491.1
ENST00000471389.6 [Q9C0B1-1]
A0A1B0GV98
ENST00000637062.1
ENST00000637845.1