Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 24 studies | 39% ± 16% | |
| astrocyte | 19 studies | 51% ± 19% | |
| oligodendrocyte | 16 studies | 48% ± 17% | |
| oligodendrocyte precursor cell | 14 studies | 47% ± 17% | |
| microglial cell | 14 studies | 45% ± 12% | |
| glutamatergic neuron | 13 studies | 57% ± 26% | |
| ciliated cell | 12 studies | 51% ± 22% | |
| GABAergic neuron | 11 studies | 58% ± 24% | |
| fibroblast | 11 studies | 49% ± 12% | |
| macrophage | 10 studies | 37% ± 16% | |
| smooth muscle cell | 10 studies | 34% ± 10% | |
| pericyte | 9 studies | 40% ± 15% | |
| adipocyte | 8 studies | 44% ± 9% | |
| endothelial cell of lymphatic vessel | 8 studies | 39% ± 14% | |
| neuron | 7 studies | 51% ± 24% | |
| mast cell | 7 studies | 27% ± 6% | |
| epithelial cell | 6 studies | 40% ± 20% | |
| interneuron | 6 studies | 67% ± 21% | |
| B cell | 6 studies | 25% ± 6% | |
| T cell | 6 studies | 28% ± 10% | |
| club cell | 6 studies | 35% ± 17% | |
| retinal ganglion cell | 5 studies | 37% ± 20% | |
| myeloid cell | 5 studies | 25% ± 7% | |
| retinal cone cell | 5 studies | 40% ± 16% | |
| cardiac muscle cell | 5 studies | 39% ± 8% | |
| mesothelial cell | 5 studies | 36% ± 13% | |
| basal cell | 5 studies | 48% ± 21% | |
| type I pneumocyte | 5 studies | 41% ± 8% | |
| type II pneumocyte | 5 studies | 41% ± 8% | |
| granule cell | 4 studies | 51% ± 12% | |
| dendritic cell | 4 studies | 23% ± 1% | |
| Mueller cell | 4 studies | 46% ± 14% | |
| amacrine cell | 4 studies | 54% ± 9% | |
| retina horizontal cell | 4 studies | 51% ± 14% | |
| retinal rod cell | 4 studies | 47% ± 9% | |
| luminal hormone-sensing cell of mammary gland | 4 studies | 24% ± 2% | |
| respiratory goblet cell | 4 studies | 41% ± 21% | |
| monocyte | 4 studies | 31% ± 10% | |
| differentiation-committed oligodendrocyte precursor | 3 studies | 53% ± 5% | |
| GABAergic interneuron | 3 studies | 63% ± 3% | |
| glial cell | 3 studies | 38% ± 8% | |
| progenitor cell | 3 studies | 36% ± 7% | |
| plasma cell | 3 studies | 32% ± 3% | |
| CD4-positive, alpha-beta T cell | 3 studies | 23% ± 2% | |
| CD8-positive, alpha-beta T cell | 3 studies | 20% ± 3% | |
| vein endothelial cell | 3 studies | 40% ± 23% | |
| GABAergic amacrine cell | 3 studies | 49% ± 14% | |
| glycinergic amacrine cell | 3 studies | 45% ± 9% | |
| Schwann cell | 3 studies | 32% ± 15% | |
| endothelial cell of vascular tree | 3 studies | 43% ± 20% | |
| hepatocyte | 3 studies | 53% ± 18% | |
| retinal pigment epithelial cell | 3 studies | 50% ± 19% | |
| abnormal cell | 3 studies | 32% ± 18% | |
| connective tissue cell | 3 studies | 30% ± 6% | |
| ependymal cell | 3 studies | 63% ± 20% | |
| alveolar macrophage | 3 studies | 36% ± 8% | |
| capillary endothelial cell | 3 studies | 32% ± 5% | |
| myofibroblast cell | 3 studies | 40% ± 17% | |
| natural killer cell | 3 studies | 22% ± 3% | |
| lymphocyte | 3 studies | 34% ± 12% | |
| muscle cell | 3 studies | 41% ± 28% | |
| mucus secreting cell | 3 studies | 34% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 5112.95 | 2642 / 2642 | 100% | 20.55 | 705 / 705 |
| esophagus | 100% | 2652.58 | 1444 / 1445 | 100% | 8.77 | 183 / 183 |
| breast | 100% | 4336.18 | 459 / 459 | 100% | 12.68 | 1114 / 1118 |
| thymus | 100% | 3249.07 | 653 / 653 | 99% | 8.43 | 599 / 605 |
| skin | 100% | 3582.26 | 1808 / 1809 | 99% | 9.47 | 467 / 472 |
| lung | 100% | 3290.23 | 577 / 578 | 99% | 7.28 | 1143 / 1155 |
| adrenal gland | 100% | 4857.45 | 258 / 258 | 99% | 11.28 | 227 / 230 |
| kidney | 100% | 2047.31 | 89 / 89 | 98% | 15.37 | 883 / 901 |
| intestine | 100% | 2679.03 | 964 / 966 | 98% | 5.28 | 517 / 527 |
| prostate | 100% | 2726.50 | 245 / 245 | 98% | 7.15 | 491 / 502 |
| stomach | 99% | 1840.96 | 357 / 359 | 97% | 5.95 | 277 / 286 |
| ovary | 100% | 3185.21 | 180 / 180 | 96% | 5.60 | 413 / 430 |
| bladder | 100% | 3212.10 | 21 / 21 | 96% | 5.62 | 484 / 504 |
| pancreas | 97% | 1232.13 | 318 / 328 | 99% | 6.85 | 176 / 178 |
| uterus | 100% | 3913.80 | 170 / 170 | 95% | 5.79 | 438 / 459 |
| liver | 93% | 1053.00 | 210 / 226 | 78% | 3.36 | 316 / 406 |
| adipose | 100% | 3447.08 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 4321.67 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2787.43 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1711.38 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.61 | 1 / 1 |
| heart | 95% | 2226.65 | 815 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 91% | 5.36 | 73 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 5.26 | 41 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 4.16 | 26 / 29 |
| peripheral blood | 46% | 815.02 | 423 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016180 | Biological process | snRNA processing |
| GO_0090335 | Biological process | regulation of brown fat cell differentiation |
| GO_0061157 | Biological process | mRNA destabilization |
| GO_0040014 | Biological process | regulation of multicellular organism growth |
| GO_0070350 | Biological process | regulation of white fat cell proliferation |
| GO_0006307 | Biological process | DNA alkylation repair |
| GO_0044065 | Biological process | regulation of respiratory system process |
| GO_0010883 | Biological process | regulation of lipid storage |
| GO_0042245 | Biological process | RNA repair |
| GO_0060612 | Biological process | adipose tissue development |
| GO_0001659 | Biological process | temperature homeostasis |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005634 | Cellular component | nucleus |
| GO_0035516 | Molecular function | broad specificity oxidative DNA demethylase activity |
| GO_0016740 | Molecular function | transferase activity |
| GO_0008198 | Molecular function | ferrous iron binding |
| GO_0035515 | Molecular function | oxidative RNA demethylase activity |
| GO_1990931 | Molecular function | mRNA N6-methyladenosine dioxygenase activity |
| GO_1990984 | Molecular function | tRNA demethylase activity |
| Gene name | FTO |
| Protein name | FTO alpha-ketoglutarate dependent dioxygenase Alpha-ketoglutarate-dependent dioxygenase FTO (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (EC 1.14.11.-) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (EC 1.14.11.-) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (m6A(m)-demethylase FTO) (EC 1.14.11.-) (mRNA N(6)-methyladenosine demethylase FTO) (EC 1.14.11.53) (tRNA N1-methyl adenine demethylase FTO) (EC 1.14.11.-) Alpha-ketoglutarate-dependent dioxygenase FTO (EC 1.14.11.53) (Fat mass and obesity-associated protein) (U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO) (mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO) (mRNA N(6)-methyladenosine demethylase FTO) (tRNA N1-methyl adenine demethylase FTO) |
| Synonyms | KIAA1752 |
| Description | FUNCTION: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis . Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes . M6A demethylation by FTO affects mRNA expression and stability . Also able to demethylate m6A in U6 small nuclear RNA (snRNA) . Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA . Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping . Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs . Has no activity towards 1-methylguanine . Has no detectable activity towards double-stranded DNA . Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine . Ability to repair alkylated DNA and RNA is however unsure in vivo . Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation . Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells . Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression . . |
| Accessions | X6R3I0 A0A1B0GVH5 ENST00000563011.2 ENST00000463855.1 [Q9C0B1-2] A0A1B0GTC3 ENST00000637001.1 ENST00000637562.1 A0A1B0GU26 ENST00000612285.2 A0A1B0GTY5 ENST00000460382.5 [Q9C0B1-4] F8WCB8 ENST00000637049.1 A0A1B0GTY1 A0A1B0GTC5 A0A1B0GUY7 Q9C0B1 A0A1B0GUC3 ENST00000464071.1 A0A1B0GTI3 ENST00000636218.1 ENST00000268349.7 ENST00000431610.6 [Q9C0B1-4] A0A1B0GTZ8 ENST00000636992.1 ENST00000637969.1 ENST00000636491.1 ENST00000471389.6 [Q9C0B1-1] A0A1B0GV98 ENST00000637062.1 ENST00000637845.1 |