Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 19 studies | 45% ± 16% | |
| astrocyte | 18 studies | 63% ± 20% | |
| oligodendrocyte | 15 studies | 64% ± 18% | |
| microglial cell | 15 studies | 62% ± 13% | |
| oligodendrocyte precursor cell | 13 studies | 72% ± 15% | |
| macrophage | 12 studies | 47% ± 17% | |
| fibroblast | 12 studies | 40% ± 14% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 10 studies | 25% ± 6% | |
| adipocyte | 10 studies | 57% ± 19% | |
| smooth muscle cell | 9 studies | 33% ± 12% | |
| GABAergic neuron | 9 studies | 53% ± 25% | |
| glutamatergic neuron | 9 studies | 56% ± 23% | |
| mast cell | 9 studies | 31% ± 12% | |
| epithelial cell | 8 studies | 46% ± 23% | |
| mesothelial cell | 7 studies | 42% ± 15% | |
| ciliated cell | 7 studies | 39% ± 22% | |
| myeloid cell | 7 studies | 46% ± 18% | |
| endothelial cell of lymphatic vessel | 7 studies | 37% ± 14% | |
| pericyte | 6 studies | 23% ± 7% | |
| interneuron | 6 studies | 51% ± 25% | |
| retinal ganglion cell | 6 studies | 52% ± 27% | |
| cardiac muscle cell | 6 studies | 69% ± 19% | |
| basal cell | 6 studies | 50% ± 23% | |
| neuron | 5 studies | 40% ± 25% | |
| CD4-positive, alpha-beta T cell | 5 studies | 26% ± 6% | |
| retinal pigment epithelial cell | 5 studies | 73% ± 12% | |
| dendritic cell | 5 studies | 30% ± 8% | |
| retinal cone cell | 5 studies | 51% ± 19% | |
| B cell | 5 studies | 26% ± 7% | |
| monocyte | 5 studies | 42% ± 13% | |
| T cell | 5 studies | 28% ± 15% | |
| club cell | 5 studies | 54% ± 20% | |
| type I pneumocyte | 5 studies | 60% ± 7% | |
| type II pneumocyte | 5 studies | 67% ± 10% | |
| cholangiocyte | 4 studies | 65% ± 14% | |
| hepatocyte | 4 studies | 71% ± 23% | |
| plasma cell | 4 studies | 40% ± 13% | |
| Mueller cell | 4 studies | 41% ± 11% | |
| retina horizontal cell | 4 studies | 48% ± 18% | |
| retinal rod cell | 4 studies | 29% ± 8% | |
| differentiation-committed oligodendrocyte precursor | 3 studies | 61% ± 10% | |
| GABAergic interneuron | 3 studies | 45% ± 12% | |
| glial cell | 3 studies | 37% ± 18% | |
| granule cell | 3 studies | 33% ± 20% | |
| pro-B cell | 3 studies | 47% ± 8% | |
| GABAergic amacrine cell | 3 studies | 41% ± 13% | |
| ON-bipolar cell | 3 studies | 35% ± 21% | |
| glycinergic amacrine cell | 3 studies | 25% ± 7% | |
| alveolar macrophage | 3 studies | 64% ± 3% | |
| capillary endothelial cell | 3 studies | 22% ± 7% | |
| respiratory goblet cell | 3 studies | 63% ± 23% | |
| mucus secreting cell | 3 studies | 54% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 678.60 | 653 / 653 | 100% | 6.22 | 604 / 605 |
| kidney | 100% | 818.26 | 89 / 89 | 99% | 5.30 | 896 / 901 |
| prostate | 100% | 297.88 | 244 / 245 | 99% | 5.09 | 499 / 502 |
| ovary | 99% | 335.99 | 179 / 180 | 100% | 5.58 | 428 / 430 |
| brain | 100% | 418.50 | 2631 / 2642 | 99% | 4.62 | 700 / 705 |
| pancreas | 100% | 342.32 | 328 / 328 | 94% | 3.91 | 168 / 178 |
| liver | 96% | 243.16 | 218 / 226 | 98% | 4.63 | 397 / 406 |
| breast | 100% | 436.50 | 459 / 459 | 94% | 3.81 | 1049 / 1118 |
| intestine | 100% | 308.00 | 964 / 966 | 93% | 3.07 | 489 / 527 |
| adrenal gland | 100% | 971.96 | 258 / 258 | 91% | 3.89 | 209 / 230 |
| stomach | 100% | 296.97 | 359 / 359 | 91% | 2.90 | 259 / 286 |
| bladder | 100% | 285.19 | 21 / 21 | 80% | 2.48 | 405 / 504 |
| lung | 99% | 238.26 | 571 / 578 | 79% | 1.87 | 916 / 1155 |
| skin | 84% | 253.08 | 1515 / 1809 | 94% | 4.63 | 443 / 472 |
| uterus | 100% | 216.82 | 170 / 170 | 65% | 2.15 | 300 / 459 |
| esophagus | 100% | 252.45 | 1438 / 1445 | 64% | 1.47 | 117 / 183 |
| eye | 0% | 0 | 0 / 0 | 100% | 10.12 | 80 / 80 |
| spleen | 100% | 349.74 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 99% | 222.12 | 1189 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 243.83 | 1303 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 4.10 | 28 / 29 |
| heart | 96% | 386.20 | 823 / 861 | 0% | 0 | 0 / 0 |
| muscle | 92% | 127.61 | 738 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 90% | 303.92 | 834 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 40% | 0.78 | 18 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006163 | Biological process | purine nucleotide metabolic process |
| GO_0015964 | Biological process | diadenosine triphosphate catabolic process |
| GO_0032435 | Biological process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO_0072332 | Biological process | intrinsic apoptotic signaling pathway by p53 class mediator |
| GO_0001650 | Cellular component | fibrillar center |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005634 | Cellular component | nucleus |
| GO_0047627 | Molecular function | adenylylsulfatase activity |
| GO_0043530 | Molecular function | adenosine 5'-monophosphoramidase activity |
| GO_0047710 | Molecular function | bis(5'-adenosyl)-triphosphatase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0047352 | Molecular function | adenylylsulfate-ammonia adenylyltransferase activity |
| GO_0000166 | Molecular function | nucleotide binding |
| Gene name | FHIT |
| Protein name | Diadenosine triphosphate hydrolase (FHIT) Fragile histidine triad diadenosine triphosphatase Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Adenosine 5'-monophosphoramidase FHIT) (EC 3.9.1.-) (Adenylylsulfatase) (EC 3.6.2.1) (Adenylylsulfate-ammonia adenylyltransferase) (EC 2.7.7.51) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein) Diadenosine triphosphate hydrolase Diadenosine triphosphate hydroxylase Fragile histidine triad FHIT Truncated diadenosine triphosphate hydroxylase |
| Synonyms | |
| Description | FUNCTION: Possesses dinucleoside triphosphate hydrolase activity . Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP . Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP . Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate . Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 . Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate . Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate . Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 . Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways . Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis . Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake . Functions as a tumor suppressor (By similarity). . |
| Accessions | ENST00000468189.5 O00298 ENST00000492590.6 ENST00000488467.5 P49789 Q0MQR8 Q194U9 E9PBZ0 Q71VB2 Q194U8 Q194V0 Q0PUW1 Q1WAB3 Q1WAB4 ENST00000476844.5 Q5G284 |