FHIT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006163Biological processpurine nucleotide metabolic process
GO_0015964Biological processdiadenosine triphosphate catabolic process
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0047627Molecular functionadenylylsulfatase activity
GO_0043530Molecular functionadenosine 5'-monophosphoramidase activity
GO_0047710Molecular functionbis(5'-adenosyl)-triphosphatase activity
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0047352Molecular functionadenylylsulfate-ammonia adenylyltransferase activity
GO_0000166Molecular functionnucleotide binding

IV. Literature review

[source]
Gene nameFHIT
Protein nameDiadenosine triphosphate hydrolase (FHIT)
Fragile histidine triad diadenosine triphosphatase
Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Adenosine 5'-monophosphoramidase FHIT) (EC 3.9.1.-) (Adenylylsulfatase) (EC 3.6.2.1) (Adenylylsulfate-ammonia adenylyltransferase) (EC 2.7.7.51) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (Fragile histidine triad protein)
Diadenosine triphosphate hydrolase
Diadenosine triphosphate hydroxylase
Fragile histidine triad
FHIT
Truncated diadenosine triphosphate hydroxylase
Synonyms
DescriptionFUNCTION: Possesses dinucleoside triphosphate hydrolase activity . Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP . Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP . Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate . Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 . Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate . Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate . Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 . Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways . Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis . Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake . Functions as a tumor suppressor (By similarity). .

AccessionsENST00000468189.5
O00298
ENST00000492590.6
ENST00000488467.5
P49789
Q0MQR8
Q194U9
E9PBZ0
Q71VB2
Q194U8
Q194V0
Q0PUW1
Q1WAB3
Q1WAB4
ENST00000476844.5
Q5G284