FBXO11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0042981Biological processregulation of apoptotic process
GO_0036211Biological processprotein modification process
GO_0005730Cellular componentnucleolus
GO_0000151Cellular componentubiquitin ligase complex
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0016274Molecular functionprotein-arginine N-methyltransferase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameFBXO11
Protein nameAlternative protein FBXO11
F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1)
F-box protein 11, isoform CRA_f (cDNA FLJ40415 fis, clone TESTI2038104, highly similar to F-box only protein 11)
F-box protein 11
SynonymsVIT1
UG063H01
PRMT9
hCG_1987171
FBX11
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis. Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks . Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta . Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome . Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis. Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 . .

AccessionsA0A804HK63
H0YAV3
L8E8F1
E7EP88
ENST00000402508.5 [Q86XK2-6]
Q86XK2
ENST00000493962.6
ENST00000434234.5
ENST00000403359.8 [Q86XK2-1]
ENST00000405808.5
C9IYF0
ENST00000683894.1
B3KUR1
ENST00000424163.2
B5MCV6