EXOSC8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071038Biological processTRAMP-dependent tRNA surveillance pathway
GO_0071035Biological processnuclear polyadenylation-dependent rRNA catabolic process
GO_0006396Biological processRNA processing
GO_0034475Biological processU4 snRNA 3'-end processing
GO_0006401Biological processRNA catabolic process
GO_0034473Biological processU1 snRNA 3'-end processing
GO_0034476Biological processU5 snRNA 3'-end processing
GO_0071028Biological processnuclear mRNA surveillance
GO_0000288Biological processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0000467Biological processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0005730Cellular componentnucleolus
GO_0000178Cellular componentexosome (RNase complex)
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0000177Cellular componentcytoplasmic exosome (RNase complex)
GO_0101019Cellular componentnucleolar exosome (RNase complex)
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005694Cellular componentchromosome
GO_0000176Cellular componentnuclear exosome (RNase complex)
GO_0005634Cellular componentnucleus
GO_0004532Molecular functionRNA exonuclease activity
GO_0042802Molecular functionidentical protein binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEXOSC8
Protein nameRibosomal RNA-processing protein 43
Exosome component 8
Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)
SynonymsOIP2
RRP43
DescriptionFUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. .

AccessionsENST00000389704.4
A0A8I5KRG4
ENST00000692761.1
ENST00000692588.1
A0A8I5QJI7
ENST00000239893.9
A0A8I5KRX4
ENST00000690774.1
ENST00000693100.1
ENST00000688436.1
H7C5Z2
A0A8I5KVC8
ENST00000687944.1
ENST00000691611.1
ENST00000481013.1
ENST00000692143.1
ENST00000685624.1
H7C581
ENST00000687482.1
ENST00000688064.1
ENST00000692787.1
ENST00000689744.1
Q96B26
ENST00000692636.1
ENST00000686729.1
ENST00000689948.1
A0A8I5KNS0