ELOVL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0030148Biological processsphingolipid biosynthetic process
GO_0042761Biological processvery long-chain fatty acid biosynthetic process
GO_0034626Biological processfatty acid elongation, polyunsaturated fatty acid
GO_0036109Biological processalpha-linolenic acid metabolic process
GO_0019367Biological processfatty acid elongation, saturated fatty acid
GO_0006636Biological processunsaturated fatty acid biosynthetic process
GO_0043651Biological processlinoleic acid metabolic process
GO_0034625Biological processfatty acid elongation, monounsaturated fatty acid
GO_0061436Biological processestablishment of skin barrier
GO_0046513Biological processceramide biosynthetic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0009922Molecular functionfatty acid elongase activity

IV. Literature review

[source]
Gene nameELOVL1
Protein nameVery long chain fatty acid elongase 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Elongation of very long chain fatty acids protein 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3-oxoacyl-CoA synthase 1)
Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3-oxoacyl-CoA synthase 1)
Elongation of very long chain fatty acids protein (EC 2.3.1.199) (Very-long-chain 3-oxoacyl-CoA synthase)
SynonymsSSC1
CGI-88
DescriptionFUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle . This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis . Indirectly inhibits RPE65 via production of VLCFAs. .

FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. .

AccessionsQ502X7
A0A3G2LMN0
ENST00000372458.8 [Q9BW60-1]
ENST00000413844.3 [Q9BW60-2]
ENST00000621943.4 [Q9BW60-1]
Q9BW60