ELL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0042795Biological processsnRNA transcription by RNA polymerase II
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0008023Cellular componenttranscription elongation factor complex
GO_0005515Molecular functionprotein binding
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding

IV. Literature review

[source]
Gene nameELL2
Protein nameElongation factor for RNA polymerase II 2
RNA polymerase II elongation factor ELL2
Synonyms
DescriptionFUNCTION: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III . Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression. .

AccessionsA0A0U1RR08
H0Y8G1
ENST00000513343.1
O00472
D6RC27
ENST00000635633.1
ENST00000508757.1
ENST00000237853.9 [O00472-1]