EHF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030154Biological processcell differentiation
GO_0030855Biological processepithelial cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005794Cellular componentGolgi apparatus
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameEHF
Protein nameETS homologous factor (hEHF) (ETS domain-containing transcription factor) (Epithelium-specific Ets transcription factor 3) (ESE-3)
ETS homologous factor
SynonymsESE3
ESE3B
ESEJ
DescriptionFUNCTION: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. .

AccessionsENST00000532302.1
ENST00000531794.5 [Q9NZC4-3]
ENST00000531728.5
Q9NZC4
ENST00000529527.5
ENST00000525253.5
E9PN75
ENST00000533754.5 [Q9NZC4-1]
E9PPS9
ENST00000257831.8 [Q9NZC4-1]
ENST00000527935.1
ENST00000450654.6 [Q9NZC4-2]
ENST00000530286.5 [Q9NZC4-1]
E9PQR6
E9PQX0