DAAM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060071Biological processWnt signaling pathway, planar cell polarity pathway
GO_0030036Biological processactin cytoskeleton organization
GO_0001725Cellular componentstress fiber
GO_0031514Cellular componentmotile cilium
GO_0036064Cellular componentciliary basal body
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameDAAM1
Protein nameDisheveled-associated activator of morphogenesis 1
Dishevelled associated activator of morphogenesis 1
SynonymsKIAA0666
DescriptionFUNCTION: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia . Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). .

AccessionsG3V275
ENST00000556135.1
Q9Y4D1
ENST00000395125.1 [Q9Y4D1-1]
ENST00000360909.8 [Q9Y4D1-2]