CMC2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
regulatory T cell	17 studies	21% ± 4%	Explore
CD8-positive, alpha-beta T cell	14 studies	24% ± 7%	Explore
natural killer cell	13 studies	21% ± 6%	Explore
CD4-positive, alpha-beta T cell	11 studies	26% ± 10%	Explore
T cell	9 studies	19% ± 6%	Explore
endothelial cell	8 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 7%	Explore
mature NK T cell	7 studies	17% ± 2%	Explore
gamma-delta T cell	7 studies	24% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	20% ± 5%	Explore
glutamatergic neuron	6 studies	33% ± 19%	Explore
epithelial cell	6 studies	34% ± 16%	Explore
oligodendrocyte	6 studies	28% ± 8%	Explore
astrocyte	6 studies	27% ± 10%	Explore
macrophage	5 studies	21% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	18% ± 1%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	19% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 6%	Explore
cardiac muscle cell	5 studies	18% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	21% ± 7%	Explore
fibroblast	5 studies	18% ± 4%	Explore
oligodendrocyte precursor cell	5 studies	29% ± 10%	Explore
GABAergic neuron	5 studies	30% ± 16%	Explore
mast cell	4 studies	23% ± 8%	Explore
non-classical monocyte	4 studies	28% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	18% ± 3%	Explore
conventional dendritic cell	4 studies	29% ± 9%	Explore
neuron	4 studies	26% ± 9%	Explore
mucosal invariant T cell	4 studies	19% ± 1%	Explore
T follicular helper cell	4 studies	20% ± 3%	Explore
interneuron	4 studies	37% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	19% ± 4%	Explore
plasmablast	3 studies	51% ± 15%	Explore
classical monocyte	3 studies	23% ± 3%	Explore
kidney loop of Henle epithelial cell	3 studies	16% ± 1%	Explore
myofibroblast cell	3 studies	17% ± 2%	Explore
epithelial cell of proximal tubule	3 studies	19% ± 2%	Explore
B cell	3 studies	21% ± 2%	Explore
myeloid cell	3 studies	24% ± 5%	Explore
ciliated cell	3 studies	31% ± 9%	Explore
exhausted T cell	3 studies	21% ± 3%	Explore
basal cell	3 studies	27% ± 10%	Explore
dendritic cell	3 studies	35% ± 13%	Explore
monocyte	3 studies	16% ± 1%	Explore
hepatocyte	3 studies	42% ± 16%	Explore
T-helper 17 cell	3 studies	25% ± 10%	Explore
plasmacytoid dendritic cell	3 studies	25% ± 4%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
brain	7 studies	30% ± 13%	Explore
peripheral blood	6 studies	21% ± 5%	Explore
kidney	4 studies	18% ± 2%	Explore
lung	3 studies	29% ± 9%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2062.43	2642 / 2642	100%	5.10	705 / 705
liver	100%	938.06	226 / 226	100%	3.36	406 / 406
prostate	100%	1715.38	245 / 245	100%	5.42	502 / 502
uterus	100%	584.27	170 / 170	100%	4.70	458 / 459
kidney	100%	1468.26	89 / 89	100%	3.18	899 / 901
stomach	100%	934.92	359 / 359	100%	3.43	285 / 286
bladder	100%	885.52	21 / 21	99%	4.13	500 / 504
adrenal gland	100%	1038.62	258 / 258	99%	4.01	228 / 230
breast	100%	765.93	459 / 459	99%	2.92	1108 / 1118
intestine	100%	968.03	966 / 966	99%	3.75	522 / 527
lung	99%	974.21	574 / 578	100%	3.54	1152 / 1155
thymus	100%	853.22	651 / 653	99%	2.83	601 / 605
skin	99%	736.51	1799 / 1809	100%	4.97	470 / 472
esophagus	100%	874.99	1444 / 1445	99%	3.52	181 / 183
pancreas	99%	520.07	325 / 328	99%	3.24	177 / 178
ovary	100%	585.92	180 / 180	98%	2.36	420 / 430
lymph node	0%	0	0 / 0	100%	5.16	29 / 29
spleen	100%	1112.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	3.86	45 / 45
ureter	0%	0	0 / 0	100%	8.26	1 / 1
muscle	100%	1048.65	801 / 803	0%	0	0 / 0
adipose	100%	814.77	1201 / 1204	0%	0	0 / 0
blood vessel	99%	755.70	1327 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	2.70	79 / 80
heart	98%	1561.45	844 / 861	0%	0	0 / 0
peripheral blood	63%	614.23	585 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0