CKB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140651Biological processfutile creatine cycle
GO_0046314Biological processphosphocreatine biosynthetic process
GO_0021762Biological processsubstantia nigra development
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0004111Molecular functioncreatine kinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameCKB
Protein nameCreatine kinase B-type (EC 2.7.3.2) (Brain creatine kinase) (B-CK) (Creatine kinase B chain) (Creatine phosphokinase B-type) (CPK-B)
Creatine kinase B-type (EC 2.7.3.2) (Creatine kinase B chain)
Creatine kinase B
SynonymsCKBB
hCG_25499
HEL-S-29
DescriptionFUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) . Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). .

AccessionsP12277
G3V4N7
ENST00000557530.1
H0YJG0
A0A0S2Z471
ENST00000555039.1
G3V2I1
ENST00000553652.5
V9HWH2
ENST00000554989.1
ENST00000348956.7
H0YJK0
ENST00000689346.1
ENST00000553878.5
H0YJJ7
ENST00000553610.5
G3V461