CIAO1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	15 studies	21% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	10 studies	19% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	20% ± 3%	Explore
endothelial cell	8 studies	22% ± 5%	Explore
gamma-delta T cell	7 studies	21% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	16% ± 1%	Explore
mucosal invariant T cell	6 studies	18% ± 1%	Explore
epithelial cell	6 studies	30% ± 8%	Explore
classical monocyte	5 studies	19% ± 4%	Explore
regulatory T cell	5 studies	17% ± 1%	Explore
ciliated cell	5 studies	21% ± 2%	Explore
oligodendrocyte precursor cell	5 studies	24% ± 4%	Explore
plasmacytoid dendritic cell	5 studies	21% ± 3%	Explore
mature NK T cell	5 studies	18% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	19% ± 4%	Explore
naive B cell	4 studies	18% ± 2%	Explore
macrophage	4 studies	20% ± 4%	Explore
glutamatergic neuron	4 studies	46% ± 22%	Explore
conventional dendritic cell	3 studies	28% ± 9%	Explore
non-classical monocyte	3 studies	21% ± 3%	Explore
lymphocyte	3 studies	18% ± 4%	Explore
precursor B cell	3 studies	18% ± 1%	Explore
abnormal cell	3 studies	26% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
exhausted T cell	3 studies	18% ± 1%	Explore
GABAergic neuron	3 studies	42% ± 14%	Explore
astrocyte	3 studies	25% ± 5%	Explore
dendritic cell	3 studies	33% ± 8%	Explore
basal cell	3 studies	29% ± 3%	Explore
transit amplifying cell	3 studies	26% ± 12%	Explore
neuron	3 studies	22% ± 5%	Explore
double negative thymocyte	3 studies	23% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
oligodendrocyte	3 studies	19% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	5 studies	17% ± 3%	Explore
brain	5 studies	35% ± 16%	Explore
liver	3 studies	26% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	1731.00	21 / 21	100%	64.06	504 / 504
breast	100%	1940.65	459 / 459	100%	72.39	1118 / 1118
esophagus	100%	1604.09	1445 / 1445	100%	53.17	183 / 183
kidney	100%	1769.20	89 / 89	100%	61.17	901 / 901
liver	100%	1484.19	226 / 226	100%	48.87	406 / 406
lung	100%	1681.97	578 / 578	100%	63.11	1155 / 1155
ovary	100%	1497.43	180 / 180	100%	60.00	430 / 430
pancreas	100%	1242.06	328 / 328	100%	52.08	178 / 178
prostate	100%	1558.06	245 / 245	100%	59.47	502 / 502
skin	100%	2043.08	1809 / 1809	100%	94.98	472 / 472
stomach	100%	1431.85	359 / 359	100%	58.05	286 / 286
thymus	100%	1637.87	653 / 653	100%	70.14	605 / 605
uterus	100%	1646.68	170 / 170	100%	62.55	459 / 459
intestine	100%	1686.87	966 / 966	100%	62.44	526 / 527
brain	100%	1423.70	2633 / 2642	100%	93.19	705 / 705
adrenal gland	100%	3108.74	258 / 258	100%	65.91	229 / 230
adipose	100%	1972.95	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1510.20	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	66.13	80 / 80
lymph node	0%	0	0 / 0	100%	67.18	29 / 29
muscle	100%	1410.70	803 / 803	0%	0	0 / 0
spleen	100%	2056.07	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	51.97	45 / 45
ureter	0%	0	0 / 0	100%	41.08	1 / 1
heart	98%	1255.41	846 / 861	0%	0	0 / 0
peripheral blood	98%	1479.66	906 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0097428	Biological process	protein maturation by iron-sulfur cluster transfer
GO_0016226	Biological process	iron-sulfur cluster assembly
GO_0007059	Biological process	chromosome segregation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0097361	Cellular component	cytosolic [4Fe-4S] assembly targeting complex
GO_0005737	Cellular component	cytoplasm
GO_0071817	Cellular component	MMXD complex
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CIAO1
Protein name	Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39)
Synonyms	WDR39 CIA1
Description	FUNCTION: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins . As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 . Seems to specifically modulate the transactivation activity of WT1 . As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation . . FUNCTION: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. . FUNCTION: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. .
Accessions	B2RDJ6 O76071 B4DRZ6 ENST00000488633.2

CIAO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review