CHORDC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010824Biological processregulation of centrosome duplication
GO_0061077Biological processchaperone-mediated protein folding
GO_1900034Biological processregulation of cellular response to heat
GO_0051298Biological processcentrosome duplication
GO_0005575Cellular componentcellular_component
GO_0043531Molecular functionADP binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0051879Molecular functionHsp90 protein binding

IV. Literature review

[source]
Gene nameCHORDC1
Protein nameCysteine and histidine rich domain containing 1 (Cysteine and histidine-rich domain-containing protein 1)
Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)
SynonymsCHP1
DescriptionFUNCTION: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 . Proposed to act as co-chaperone for HSP90 . May play a role in the regulation of NOD1 via a HSP90 chaperone complex . In vitro, has intrinsic chaperone activity . This function may be achieved by inhibiting association of ROCK2 with NPM1 . Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling . Involved in stress response . Prevents tumorigenesis . .

AccessionsENST00000533062.5
E9PHZ2
ENST00000457199.6 [Q9UHD1-2]
Q9UHD1
E9PL00
ENST00000647001.1
E9PPQ5
ENST00000525317.5
ENST00000320585.11 [Q9UHD1-1]
ENST00000647443.1
ENST00000644919.1
E9PIZ4
ENST00000529402.1
E9PSD5
ENST00000533772.5
ENST00000646017.1
ENST00000529726.1
ENST00000530765.5
ENST00000643554.1
ENST00000647220.1 [Q9UHD1-2]
ENST00000644264.1
ENST00000643997.1
ENST00000646618.2 [Q9UHD1-1]
E9PIF7
ENST00000529987.5