CENPF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
transit amplifying cell	6 studies	28% ± 7%	Explore
T cell	6 studies	32% ± 5%	Explore
B cell	4 studies	22% ± 3%	Explore
plasmablast	4 studies	33% ± 15%	Explore
deuterosomal cell	4 studies	23% ± 5%	Explore
abnormal cell	4 studies	23% ± 7%	Explore
pro-B cell	4 studies	24% ± 3%	Explore
erythrocyte	4 studies	37% ± 16%	Explore
natural killer cell	4 studies	27% ± 7%	Explore
CD4-positive, alpha-beta T cell	4 studies	37% ± 10%	Explore
CD8-positive, alpha-beta T cell	4 studies	32% ± 9%	Explore
epithelial cell	3 studies	33% ± 10%	Explore
plasma cell	3 studies	27% ± 5%	Explore
hematopoietic precursor cell	3 studies	21% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	23% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	31% ± 4%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CENPF at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	97%	3233.72	1758 / 1809	92%	38.50	436 / 472
ovary	63%	186.42	114 / 180	89%	18.49	384 / 430
intestine	58%	654.06	559 / 966	91%	22.17	482 / 527
lung	61%	273.79	353 / 578	85%	22.91	976 / 1155
esophagus	46%	845.67	660 / 1445	99%	47.66	182 / 183
breast	46%	127.34	210 / 459	94%	38.19	1048 / 1118
stomach	46%	404.14	166 / 359	92%	24.95	263 / 286
uterus	40%	120.26	68 / 170	97%	40.74	446 / 459
bladder	19%	63.48	4 / 21	89%	24.04	450 / 504
tonsil	0%	0	0 / 0	100%	46.18	45 / 45
ureter	0%	0	0 / 0	100%	12.46	1 / 1
spleen	97%	692.47	234 / 241	0%	0	0 / 0
adrenal gland	73%	278.12	189 / 258	19%	3.31	44 / 230
lymph node	0%	0	0 / 0	90%	21.80	26 / 29
pancreas	8%	22.78	26 / 328	66%	10.20	117 / 178
brain	13%	33.06	339 / 2642	47%	10.76	328 / 705
liver	13%	64.67	30 / 226	40%	6.17	162 / 406
peripheral blood	53%	2434.02	494 / 929	0%	0	0 / 0
adipose	42%	126.86	503 / 1204	0%	0	0 / 0
prostate	25%	75.50	62 / 245	15%	1.75	74 / 502
kidney	21%	107.38	19 / 89	13%	1.86	120 / 901
thymus	16%	47.87	104 / 653	15%	5.31	92 / 605
eye	0%	0	0 / 0	16%	1.42	13 / 80
blood vessel	14%	39.45	185 / 1335	0%	0	0 / 0
heart	10%	33.37	86 / 861	0%	0	0 / 0
muscle	2%	5.22	20 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000278	Biological process	mitotic cell cycle
GO_0007059	Biological process	chromosome segregation
GO_0051310	Biological process	metaphase chromosome alignment
GO_0051382	Biological process	kinetochore assembly
GO_0001822	Biological process	kidney development
GO_0051301	Biological process	cell division
GO_0010389	Biological process	regulation of G2/M transition of mitotic cell cycle
GO_0021591	Biological process	ventricular system development
GO_0071897	Biological process	DNA biosynthetic process
GO_0030154	Biological process	cell differentiation
GO_0007517	Biological process	muscle organ development
GO_0015031	Biological process	protein transport
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0007094	Biological process	mitotic spindle assembly checkpoint signaling
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0016202	Biological process	regulation of striated muscle tissue development
GO_0000775	Cellular component	chromosome, centromeric region
GO_0097539	Cellular component	ciliary transition fiber
GO_0030496	Cellular component	midbody
GO_0000922	Cellular component	spindle pole
GO_0045120	Cellular component	pronucleus
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005813	Cellular component	centrosome
GO_0000776	Cellular component	kinetochore
GO_0005654	Cellular component	nucleoplasm
GO_0005635	Cellular component	nuclear envelope
GO_0005930	Cellular component	axoneme
GO_0016363	Cellular component	nuclear matrix
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0000940	Cellular component	outer kinetochore
GO_0036064	Cellular component	ciliary basal body
GO_0000785	Cellular component	chromatin
GO_0031965	Cellular component	nuclear membrane
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0003682	Molecular function	chromatin binding
GO_0008017	Molecular function	microtubule binding
GO_0070840	Molecular function	dynein complex binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CENPF
Protein name	Centromere protein F (CENP-F) (AH antigen) (Kinetochore protein CENPF) (Mitosin) Centromere protein F
Synonyms
Description	FUNCTION: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia. .
Accessions	ENST00000706765.1 ENST00000366955.8 A0A9L9PXU7 P49454

CENPF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review