CDK14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0016055Biological processWnt signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0051301Biological processcell division
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0051726Biological processregulation of cell cycle
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000308Cellular componentcytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity
GO_0030332Molecular functioncyclin binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameCDK14
Protein nameCyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14)
Cyclin dependent kinase 14
Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1)
SynonymsKIAA0834
PFTK1
DescriptionFUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. .

FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. .

AccessionsENST00000456689.5
ENST00000380050.8 [O94921-1]
E7EUK8
ENST00000430760.5
ENST00000436577.3
ENST00000446790.5
O94921
ENST00000431029.5
ENST00000265741.7 [O94921-2]
ENST00000446224.5
ENST00000406263.5 [O94921-3]
ENST00000449528.5
C9JWL6
F8WF96
C9IYJ9