Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 17 studies | 43% ± 21% | |
endothelial cell | 16 studies | 37% ± 18% | |
oligodendrocyte precursor cell | 15 studies | 58% ± 20% | |
glutamatergic neuron | 13 studies | 64% ± 24% | |
B cell | 12 studies | 35% ± 16% | |
fibroblast | 12 studies | 45% ± 16% | |
GABAergic neuron | 11 studies | 66% ± 21% | |
pericyte | 11 studies | 38% ± 18% | |
adipocyte | 9 studies | 28% ± 9% | |
mesothelial cell | 9 studies | 47% ± 19% | |
macrophage | 8 studies | 34% ± 20% | |
smooth muscle cell | 8 studies | 38% ± 10% | |
interneuron | 7 studies | 59% ± 28% | |
neuron | 6 studies | 52% ± 13% | |
retinal ganglion cell | 6 studies | 49% ± 18% | |
retina horizontal cell | 6 studies | 69% ± 22% | |
club cell | 6 studies | 43% ± 21% | |
microglial cell | 5 studies | 47% ± 24% | |
plasma cell | 5 studies | 51% ± 16% | |
cardiac muscle cell | 5 studies | 43% ± 11% | |
type I pneumocyte | 5 studies | 40% ± 7% | |
cholangiocyte | 4 studies | 54% ± 17% | |
epithelial cell | 4 studies | 30% ± 12% | |
granule cell | 4 studies | 55% ± 13% | |
amacrine cell | 4 studies | 62% ± 21% | |
monocyte | 4 studies | 30% ± 11% | |
type II pneumocyte | 4 studies | 20% ± 2% | |
oligodendrocyte | 4 studies | 39% ± 23% | |
hepatic stellate cell | 3 studies | 43% ± 20% | |
GABAergic interneuron | 3 studies | 73% ± 8% | |
dendritic cell | 3 studies | 25% ± 4% | |
GABAergic amacrine cell | 3 studies | 27% ± 11% | |
Mueller cell | 3 studies | 35% ± 12% | |
glycinergic amacrine cell | 3 studies | 40% ± 9% | |
retinal rod cell | 3 studies | 38% ± 17% | |
myeloid cell | 3 studies | 25% ± 7% | |
hepatocyte | 3 studies | 74% ± 21% | |
abnormal cell | 3 studies | 34% ± 7% | |
connective tissue cell | 3 studies | 29% ± 9% | |
ependymal cell | 3 studies | 49% ± 16% | |
alveolar macrophage | 3 studies | 45% ± 10% | |
respiratory goblet cell | 3 studies | 44% ± 22% | |
memory B cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 4044.71 | 2626 / 2642 | 100% | 42.25 | 703 / 705 |
prostate | 100% | 1542.71 | 244 / 245 | 98% | 16.81 | 494 / 502 |
thymus | 100% | 2296.40 | 652 / 653 | 98% | 20.51 | 593 / 605 |
kidney | 100% | 2080.54 | 89 / 89 | 96% | 22.15 | 865 / 901 |
breast | 100% | 1913.08 | 459 / 459 | 95% | 19.22 | 1059 / 1118 |
pancreas | 99% | 1171.09 | 326 / 328 | 94% | 19.69 | 168 / 178 |
ovary | 100% | 2160.35 | 180 / 180 | 89% | 12.17 | 383 / 430 |
liver | 98% | 1027.65 | 222 / 226 | 85% | 11.36 | 344 / 406 |
lung | 100% | 1893.21 | 577 / 578 | 83% | 11.31 | 957 / 1155 |
uterus | 99% | 1504.16 | 168 / 170 | 73% | 10.38 | 333 / 459 |
bladder | 100% | 1094.76 | 21 / 21 | 53% | 6.54 | 266 / 504 |
stomach | 99% | 1207.58 | 357 / 359 | 50% | 5.94 | 142 / 286 |
adrenal gland | 65% | 419.46 | 168 / 258 | 76% | 9.51 | 175 / 230 |
esophagus | 67% | 841.98 | 965 / 1445 | 73% | 10.66 | 133 / 183 |
skin | 73% | 1531.31 | 1318 / 1809 | 55% | 8.96 | 260 / 472 |
intestine | 84% | 1137.28 | 815 / 966 | 35% | 4.02 | 186 / 527 |
adipose | 100% | 2183.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2732.06 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1434.82 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 94% | 1534.92 | 810 / 861 | 0% | 0 | 0 / 0 |
muscle | 82% | 555.51 | 656 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 79% | 14.05 | 23 / 29 |
tonsil | 0% | 0 | 0 / 0 | 78% | 7.78 | 35 / 45 |
peripheral blood | 61% | 862.24 | 571 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 16% | 1.42 | 13 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0000086 | Biological process | G2/M transition of mitotic cell cycle |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0006468 | Biological process | protein phosphorylation |
GO_0051301 | Biological process | cell division |
GO_0060828 | Biological process | regulation of canonical Wnt signaling pathway |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0000307 | Cellular component | cyclin-dependent protein kinase holoenzyme complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0000308 | Cellular component | cytoplasmic cyclin-dependent protein kinase holoenzyme complex |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004693 | Molecular function | cyclin-dependent protein serine/threonine kinase activity |
GO_0030332 | Molecular function | cyclin binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | CDK14 |
Protein name | Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) Cyclin dependent kinase 14 Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) (hPFTAIRE1) |
Synonyms | KIAA0834 PFTK1 |
Description | FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. . FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. . |
Accessions | ENST00000456689.5 ENST00000380050.8 [O94921-1] E7EUK8 ENST00000430760.5 ENST00000436577.3 ENST00000446790.5 O94921 ENST00000431029.5 ENST00000265741.7 [O94921-2] ENST00000446224.5 ENST00000406263.5 [O94921-3] ENST00000449528.5 C9JWL6 F8WF96 C9IYJ9 |