CAND1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0045899Biological processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
GO_0043086Biological processnegative regulation of catalytic activity
GO_0030154Biological processcell differentiation
GO_0010265Biological processSCF complex assembly
GO_0000151Cellular componentubiquitin ligase complex
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0031461Cellular componentcullin-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0017025Molecular functionTBP-class protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAND1
Protein nameCullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1)
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
Cullin associated and neddylation dissociated 1
SynonymsTIP120
KIAA0829
TIP120A
DescriptionFUNCTION: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. .

AccessionsH0YH27
F5H6I6
ENST00000544619.1
ENST00000545606.6 [Q86VP6-1]
Q86VP6
ENST00000540525.1
A0A0C4DGH5
ENST00000540319.5