Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 41 studies | 49% ± 19% | |
| fibroblast | 27 studies | 29% ± 15% | |
| classical monocyte | 25 studies | 58% ± 14% | |
| conventional dendritic cell | 25 studies | 36% ± 20% | |
| non-classical monocyte | 23 studies | 41% ± 14% | |
| monocyte | 21 studies | 44% ± 16% | |
| basal cell | 21 studies | 39% ± 17% | |
| epithelial cell | 18 studies | 40% ± 17% | |
| myeloid cell | 16 studies | 38% ± 19% | |
| erythrocyte | 14 studies | 74% ± 19% | |
| ciliated cell | 14 studies | 31% ± 14% | |
| dendritic cell | 13 studies | 44% ± 21% | |
| endothelial cell of lymphatic vessel | 11 studies | 26% ± 19% | |
| smooth muscle cell | 10 studies | 29% ± 12% | |
| type I pneumocyte | 10 studies | 45% ± 14% | |
| connective tissue cell | 10 studies | 23% ± 6% | |
| pericyte | 10 studies | 25% ± 11% | |
| type II pneumocyte | 9 studies | 55% ± 21% | |
| goblet cell | 9 studies | 27% ± 12% | |
| secretory cell | 8 studies | 33% ± 13% | |
| mononuclear phagocyte | 7 studies | 38% ± 16% | |
| erythroblast | 7 studies | 78% ± 12% | |
| progenitor cell | 7 studies | 22% ± 5% | |
| myofibroblast cell | 7 studies | 21% ± 4% | |
| endothelial cell | 7 studies | 23% ± 4% | |
| alveolar macrophage | 6 studies | 33% ± 8% | |
| club cell | 6 studies | 34% ± 12% | |
| epithelial cell of proximal tubule | 6 studies | 35% ± 7% | |
| enterocyte | 6 studies | 48% ± 15% | |
| respiratory goblet cell | 5 studies | 30% ± 12% | |
| kidney loop of Henle epithelial cell | 5 studies | 26% ± 6% | |
| leukocyte | 5 studies | 29% ± 10% | |
| abnormal cell | 5 studies | 40% ± 13% | |
| plasma cell | 5 studies | 35% ± 13% | |
| hepatocyte | 5 studies | 43% ± 25% | |
| squamous epithelial cell | 4 studies | 38% ± 23% | |
| plasmacytoid dendritic cell | 4 studies | 19% ± 3% | |
| retinal ganglion cell | 4 studies | 67% ± 25% | |
| microglial cell | 4 studies | 23% ± 7% | |
| adventitial cell | 4 studies | 33% ± 7% | |
| keratinocyte | 4 studies | 33% ± 24% | |
| intermediate monocyte | 4 studies | 64% ± 14% | |
| luminal hormone-sensing cell of mammary gland | 4 studies | 35% ± 8% | |
| hematopoietic precursor cell | 3 studies | 24% ± 5% | |
| duct epithelial cell | 3 studies | 32% ± 11% | |
| ionocyte | 3 studies | 30% ± 2% | |
| neutrophil | 3 studies | 25% ± 3% | |
| lymphocyte | 3 studies | 21% ± 3% | |
| retina horizontal cell | 3 studies | 22% ± 3% | |
| serous secreting cell | 3 studies | 21% ± 3% | |
| tissue-resident macrophage | 3 studies | 37% ± 10% | |
| Mueller cell | 3 studies | 24% ± 4% | |
| B cell | 3 studies | 35% ± 18% | |
| melanocyte | 3 studies | 38% ± 27% | |
| myoepithelial cell | 3 studies | 27% ± 7% | |
| luminal cell of prostate epithelium | 3 studies | 23% ± 8% | |
| megakaryocyte-erythroid progenitor cell | 3 studies | 46% ± 11% | |
| glial cell | 3 studies | 19% ± 1% | |
| transit amplifying cell | 3 studies | 20% ± 2% | |
| hematopoietic stem cell | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| lung | 15 studies | 31% ± 11% | |
| peripheral blood | 14 studies | 24% ± 7% | |
| intestine | 9 studies | 24% ± 10% | |
| kidney | 6 studies | 25% ± 7% | |
| liver | 6 studies | 42% ± 26% | |
| eye | 5 studies | 19% ± 2% | |
| bone marrow | 5 studies | 26% ± 8% | |
| uterus | 4 studies | 26% ± 10% | |
| breast | 4 studies | 19% ± 1% | |
| brain | 4 studies | 18% ± 1% | |
| pancreas | 3 studies | 27% ± 9% | |
| placenta | 3 studies | 23% ± 5% | |
| skin | 3 studies | 35% ± 23% | |
| prostate | 3 studies | 30% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 4952.72 | 226 / 226 | 100% | 269.87 | 406 / 406 |
| thymus | 100% | 2487.84 | 652 / 653 | 100% | 107.69 | 603 / 605 |
| prostate | 100% | 2765.20 | 245 / 245 | 99% | 158.29 | 499 / 502 |
| kidney | 100% | 3124.08 | 89 / 89 | 99% | 131.70 | 895 / 901 |
| skin | 100% | 2525.40 | 1807 / 1809 | 99% | 117.22 | 467 / 472 |
| uterus | 100% | 2211.05 | 170 / 170 | 99% | 177.03 | 453 / 459 |
| lung | 100% | 3940.35 | 576 / 578 | 99% | 171.95 | 1141 / 1155 |
| breast | 100% | 3438.68 | 459 / 459 | 98% | 179.11 | 1100 / 1118 |
| intestine | 100% | 2680.99 | 965 / 966 | 98% | 126.82 | 519 / 527 |
| esophagus | 100% | 3972.67 | 1445 / 1445 | 98% | 119.16 | 180 / 183 |
| stomach | 100% | 3749.92 | 359 / 359 | 98% | 121.65 | 280 / 286 |
| bladder | 100% | 2873.90 | 21 / 21 | 97% | 138.80 | 491 / 504 |
| pancreas | 97% | 1429.39 | 317 / 328 | 99% | 147.34 | 177 / 178 |
| ovary | 100% | 2258.91 | 180 / 180 | 96% | 93.00 | 413 / 430 |
| adrenal gland | 100% | 2669.71 | 257 / 258 | 89% | 85.23 | 205 / 230 |
| brain | 85% | 1116.97 | 2249 / 2642 | 89% | 64.31 | 625 / 705 |
| adipose | 100% | 3636.70 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 149.70 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 91.10 | 29 / 29 |
| peripheral blood | 100% | 7505.57 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5777.02 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 172.21 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 76.93 | 1 / 1 |
| muscle | 100% | 4233.55 | 802 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2676.01 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 2581.75 | 835 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030219 | Biological process | megakaryocyte differentiation |
| GO_0046627 | Biological process | negative regulation of insulin receptor signaling pathway |
| GO_0042167 | Biological process | heme catabolic process |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0042602 | Molecular function | riboflavin reductase (NADPH) activity |
| GO_0052873 | Molecular function | FMN reductase (NADPH) activity |
| GO_0106276 | Molecular function | biliberdin reductase (NAD+) activity |
| GO_0052874 | Molecular function | FMN reductase (NADH) activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0035605 | Molecular function | peptidyl-cysteine S-nitrosylase activity |
| GO_0106277 | Molecular function | biliverdin reductase (NADP+) activity |
| GO_0008752 | Molecular function | FMN reductase (NAD(P)H) activity |
| GO_0004074 | Molecular function | biliverdin reductase [NAD(P)+] activity |
| Gene name | BLVRB |
| Protein name | Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) Biliverdin reductase B |
| Synonyms | FLR |
| Description | FUNCTION: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. . |
| Accessions | M0QZL1 ENST00000643519.1 ENST00000595483.5 P30043 A0A2R8YEP4 ENST00000597870.1 M0R192 ENST00000643596.1 ENST00000263368.9 A0A2R8Y7Y9 |