Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 41 studies | 49% ± 19% | |
fibroblast | 27 studies | 29% ± 15% | |
classical monocyte | 25 studies | 58% ± 14% | |
conventional dendritic cell | 25 studies | 36% ± 20% | |
non-classical monocyte | 23 studies | 41% ± 14% | |
monocyte | 21 studies | 44% ± 16% | |
basal cell | 21 studies | 39% ± 17% | |
epithelial cell | 18 studies | 40% ± 17% | |
myeloid cell | 16 studies | 38% ± 19% | |
erythrocyte | 14 studies | 74% ± 19% | |
ciliated cell | 14 studies | 31% ± 14% | |
dendritic cell | 13 studies | 44% ± 21% | |
endothelial cell of lymphatic vessel | 11 studies | 26% ± 19% | |
smooth muscle cell | 10 studies | 29% ± 12% | |
type I pneumocyte | 10 studies | 45% ± 14% | |
connective tissue cell | 10 studies | 23% ± 6% | |
pericyte | 10 studies | 25% ± 11% | |
type II pneumocyte | 9 studies | 55% ± 21% | |
goblet cell | 9 studies | 27% ± 12% | |
secretory cell | 8 studies | 33% ± 13% | |
mononuclear phagocyte | 7 studies | 38% ± 16% | |
erythroblast | 7 studies | 78% ± 12% | |
progenitor cell | 7 studies | 22% ± 5% | |
myofibroblast cell | 7 studies | 21% ± 4% | |
endothelial cell | 7 studies | 23% ± 4% | |
alveolar macrophage | 6 studies | 33% ± 8% | |
club cell | 6 studies | 34% ± 12% | |
epithelial cell of proximal tubule | 6 studies | 35% ± 7% | |
enterocyte | 6 studies | 48% ± 15% | |
respiratory goblet cell | 5 studies | 30% ± 12% | |
kidney loop of Henle epithelial cell | 5 studies | 26% ± 6% | |
leukocyte | 5 studies | 29% ± 10% | |
abnormal cell | 5 studies | 40% ± 13% | |
plasma cell | 5 studies | 35% ± 13% | |
hepatocyte | 5 studies | 43% ± 25% | |
squamous epithelial cell | 4 studies | 38% ± 23% | |
plasmacytoid dendritic cell | 4 studies | 19% ± 3% | |
retinal ganglion cell | 4 studies | 67% ± 25% | |
microglial cell | 4 studies | 23% ± 7% | |
adventitial cell | 4 studies | 33% ± 7% | |
keratinocyte | 4 studies | 33% ± 24% | |
intermediate monocyte | 4 studies | 64% ± 14% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 35% ± 8% | |
hematopoietic precursor cell | 3 studies | 24% ± 5% | |
duct epithelial cell | 3 studies | 32% ± 11% | |
ionocyte | 3 studies | 30% ± 2% | |
neutrophil | 3 studies | 25% ± 3% | |
lymphocyte | 3 studies | 21% ± 3% | |
retina horizontal cell | 3 studies | 22% ± 3% | |
serous secreting cell | 3 studies | 21% ± 3% | |
tissue-resident macrophage | 3 studies | 37% ± 10% | |
Mueller cell | 3 studies | 24% ± 4% | |
B cell | 3 studies | 35% ± 18% | |
melanocyte | 3 studies | 38% ± 27% | |
myoepithelial cell | 3 studies | 27% ± 7% | |
luminal cell of prostate epithelium | 3 studies | 23% ± 8% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 46% ± 11% | |
glial cell | 3 studies | 19% ± 1% | |
transit amplifying cell | 3 studies | 20% ± 2% | |
hematopoietic stem cell | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
lung | 15 studies | 31% ± 11% | |
peripheral blood | 14 studies | 24% ± 7% | |
intestine | 9 studies | 24% ± 10% | |
kidney | 6 studies | 25% ± 7% | |
liver | 6 studies | 42% ± 26% | |
eye | 5 studies | 19% ± 2% | |
bone marrow | 5 studies | 26% ± 8% | |
uterus | 4 studies | 26% ± 10% | |
breast | 4 studies | 19% ± 1% | |
brain | 4 studies | 18% ± 1% | |
pancreas | 3 studies | 27% ± 9% | |
placenta | 3 studies | 23% ± 5% | |
skin | 3 studies | 35% ± 23% | |
prostate | 3 studies | 30% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 4952.72 | 226 / 226 | 100% | 269.87 | 406 / 406 |
thymus | 100% | 2487.84 | 652 / 653 | 100% | 107.69 | 603 / 605 |
prostate | 100% | 2765.20 | 245 / 245 | 99% | 158.29 | 499 / 502 |
kidney | 100% | 3124.08 | 89 / 89 | 99% | 131.70 | 895 / 901 |
skin | 100% | 2525.40 | 1807 / 1809 | 99% | 117.22 | 467 / 472 |
uterus | 100% | 2211.05 | 170 / 170 | 99% | 177.03 | 453 / 459 |
lung | 100% | 3940.35 | 576 / 578 | 99% | 171.95 | 1141 / 1155 |
breast | 100% | 3438.68 | 459 / 459 | 98% | 179.11 | 1100 / 1118 |
intestine | 100% | 2680.99 | 965 / 966 | 98% | 126.82 | 519 / 527 |
esophagus | 100% | 3972.67 | 1445 / 1445 | 98% | 119.16 | 180 / 183 |
stomach | 100% | 3749.92 | 359 / 359 | 98% | 121.65 | 280 / 286 |
bladder | 100% | 2873.90 | 21 / 21 | 97% | 138.80 | 491 / 504 |
pancreas | 97% | 1429.39 | 317 / 328 | 99% | 147.34 | 177 / 178 |
ovary | 100% | 2258.91 | 180 / 180 | 96% | 93.00 | 413 / 430 |
adrenal gland | 100% | 2669.71 | 257 / 258 | 89% | 85.23 | 205 / 230 |
brain | 85% | 1116.97 | 2249 / 2642 | 89% | 64.31 | 625 / 705 |
adipose | 100% | 3636.70 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 149.70 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 91.10 | 29 / 29 |
peripheral blood | 100% | 7505.57 | 929 / 929 | 0% | 0 | 0 / 0 |
spleen | 100% | 5777.02 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 172.21 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 76.93 | 1 / 1 |
muscle | 100% | 4233.55 | 802 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2676.01 | 1331 / 1335 | 0% | 0 | 0 / 0 |
heart | 97% | 2581.75 | 835 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0030219 | Biological process | megakaryocyte differentiation |
GO_0046627 | Biological process | negative regulation of insulin receptor signaling pathway |
GO_0042167 | Biological process | heme catabolic process |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0042602 | Molecular function | riboflavin reductase (NADPH) activity |
GO_0052873 | Molecular function | FMN reductase (NADPH) activity |
GO_0106276 | Molecular function | biliberdin reductase (NAD+) activity |
GO_0052874 | Molecular function | FMN reductase (NADH) activity |
GO_0005515 | Molecular function | protein binding |
GO_0035605 | Molecular function | peptidyl-cysteine S-nitrosylase activity |
GO_0106277 | Molecular function | biliverdin reductase (NADP+) activity |
GO_0008752 | Molecular function | FMN reductase (NAD(P)H) activity |
GO_0004074 | Molecular function | biliverdin reductase [NAD(P)+] activity |
Gene name | BLVRB |
Protein name | Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) Biliverdin reductase B |
Synonyms | FLR |
Description | FUNCTION: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. . |
Accessions | M0QZL1 ENST00000643519.1 ENST00000595483.5 P30043 A0A2R8YEP4 ENST00000597870.1 M0R192 ENST00000643596.1 ENST00000263368.9 A0A2R8Y7Y9 |