BLVRB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030219Biological processmegakaryocyte differentiation
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0042167Biological processheme catabolic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0042602Molecular functionriboflavin reductase (NADPH) activity
GO_0052873Molecular functionFMN reductase (NADPH) activity
GO_0106276Molecular functionbiliberdin reductase (NAD+) activity
GO_0052874Molecular functionFMN reductase (NADH) activity
GO_0005515Molecular functionprotein binding
GO_0035605Molecular functionpeptidyl-cysteine S-nitrosylase activity
GO_0106277Molecular functionbiliverdin reductase (NADP+) activity
GO_0008752Molecular functionFMN reductase (NAD(P)H) activity
GO_0004074Molecular functionbiliverdin reductase [NAD(P)+] activity

IV. Literature review

[source]
Gene nameBLVRB
Protein nameFlavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR)
Biliverdin reductase B
SynonymsFLR
DescriptionFUNCTION: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. .

AccessionsM0QZL1
ENST00000643519.1
ENST00000595483.5
P30043
A0A2R8YEP4
ENST00000597870.1
M0R192
ENST00000643596.1
ENST00000263368.9
A0A2R8Y7Y9