BAZ1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006974Biological processDNA damage response
GO_1905213Biological processnegative regulation of mitotic chromosome condensation
GO_0043687Biological processpost-translational protein modification
GO_0006338Biological processchromatin remodeling
GO_0045945Biological processpositive regulation of transcription by RNA polymerase III
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0043596Cellular componentnuclear replication fork
GO_0005730Cellular componentnucleolus
GO_0110016Cellular componentB-WICH complex
GO_0005654Cellular componentnucleoplasm
GO_0090535Cellular componentWICH complex
GO_0005721Cellular componentpericentric heterochromatin
GO_0000793Cellular componentcondensed chromosome
GO_0005634Cellular componentnucleus
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0042393Molecular functionhistone binding
GO_0140801Molecular functionhistone H2AXY142 kinase activity
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0035173Molecular functionhistone kinase activity

IV. Literature review

[source]
Gene nameBAZ1B
Protein nameTyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2)
SynonymsWBSCR9
WSTF
WBSC10
WBSCR10
DescriptionFUNCTION: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator . Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) . H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress . Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair . Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template . The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex . The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription . Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication . .

AccessionsENST00000339594.9 [Q9UIG0-1]
Q9UIG0
ENST00000404251.1 [Q9UIG0-1]