Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 29 studies | 51% ± 22% | |
astrocyte | 18 studies | 74% ± 19% | |
oligodendrocyte | 16 studies | 72% ± 21% | |
microglial cell | 16 studies | 63% ± 19% | |
fibroblast | 16 studies | 51% ± 21% | |
oligodendrocyte precursor cell | 15 studies | 43% ± 18% | |
glutamatergic neuron | 13 studies | 81% ± 19% | |
pericyte | 13 studies | 49% ± 21% | |
smooth muscle cell | 12 studies | 53% ± 22% | |
GABAergic neuron | 11 studies | 80% ± 24% | |
macrophage | 11 studies | 43% ± 18% | |
neuron | 10 studies | 49% ± 28% | |
adipocyte | 10 studies | 53% ± 20% | |
natural killer cell | 9 studies | 27% ± 10% | |
B cell | 9 studies | 37% ± 16% | |
endothelial cell of lymphatic vessel | 9 studies | 62% ± 24% | |
basal cell | 8 studies | 42% ± 21% | |
epithelial cell | 8 studies | 36% ± 21% | |
ciliated cell | 7 studies | 25% ± 7% | |
club cell | 7 studies | 43% ± 24% | |
dendritic cell | 7 studies | 42% ± 22% | |
mesothelial cell | 7 studies | 45% ± 17% | |
T cell | 7 studies | 28% ± 13% | |
CD16-positive, CD56-dim natural killer cell, human | 6 studies | 23% ± 7% | |
interneuron | 6 studies | 87% ± 17% | |
amacrine cell | 6 studies | 68% ± 34% | |
retina horizontal cell | 6 studies | 74% ± 33% | |
type I pneumocyte | 6 studies | 23% ± 9% | |
type II pneumocyte | 6 studies | 71% ± 25% | |
capillary endothelial cell | 5 studies | 41% ± 20% | |
cardiac muscle cell | 5 studies | 51% ± 10% | |
myeloid cell | 5 studies | 38% ± 15% | |
cholangiocyte | 4 studies | 63% ± 14% | |
glial cell | 4 studies | 38% ± 13% | |
granule cell | 4 studies | 65% ± 26% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 38% ± 19% | |
CD8-positive, alpha-beta T cell | 4 studies | 22% ± 3% | |
effector memory CD8-positive, alpha-beta T cell | 4 studies | 21% ± 3% | |
vein endothelial cell | 4 studies | 25% ± 2% | |
Mueller cell | 4 studies | 86% ± 14% | |
ON-bipolar cell | 4 studies | 59% ± 38% | |
retinal cone cell | 4 studies | 66% ± 26% | |
retinal ganglion cell | 4 studies | 80% ± 19% | |
retinal rod cell | 4 studies | 86% ± 13% | |
respiratory goblet cell | 4 studies | 46% ± 25% | |
mast cell | 4 studies | 26% ± 13% | |
ionocyte | 3 studies | 40% ± 4% | |
leukocyte | 3 studies | 30% ± 14% | |
hepatic stellate cell | 3 studies | 59% ± 18% | |
GABAergic interneuron | 3 studies | 83% ± 17% | |
progenitor cell | 3 studies | 63% ± 29% | |
endocardial cell | 3 studies | 50% ± 24% | |
mucosal invariant T cell | 3 studies | 28% ± 7% | |
lymphocyte | 3 studies | 39% ± 13% | |
GABAergic amacrine cell | 3 studies | 93% ± 7% | |
OFF-bipolar cell | 3 studies | 67% ± 35% | |
glycinergic amacrine cell | 3 studies | 76% ± 17% | |
rod bipolar cell | 3 studies | 74% ± 33% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 32% ± 12% | |
mature NK T cell | 3 studies | 30% ± 15% | |
endothelial cell of vascular tree | 3 studies | 33% ± 3% | |
hepatocyte | 3 studies | 55% ± 22% | |
retinal pigment epithelial cell | 3 studies | 62% ± 25% | |
abnormal cell | 3 studies | 36% ± 14% | |
connective tissue cell | 3 studies | 49% ± 25% | |
ependymal cell | 3 studies | 67% ± 15% | |
chondrocyte | 3 studies | 61% ± 26% | |
monocyte | 3 studies | 28% ± 5% | |
myofibroblast cell | 3 studies | 62% ± 30% | |
muscle cell | 3 studies | 42% ± 20% | |
goblet cell | 3 studies | 28% ± 17% | |
transit amplifying cell | 3 studies | 40% ± 29% | |
mucus secreting cell | 3 studies | 40% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2827.91 | 2634 / 2642 | 99% | 9.35 | 699 / 705 |
ovary | 100% | 4036.64 | 180 / 180 | 98% | 8.55 | 423 / 430 |
breast | 100% | 4963.83 | 459 / 459 | 98% | 15.35 | 1099 / 1118 |
intestine | 100% | 2451.83 | 966 / 966 | 92% | 8.26 | 483 / 527 |
prostate | 100% | 3577.80 | 245 / 245 | 90% | 5.27 | 452 / 502 |
lung | 100% | 3220.51 | 577 / 578 | 87% | 9.09 | 1001 / 1155 |
esophagus | 100% | 3296.39 | 1445 / 1445 | 86% | 8.69 | 157 / 183 |
uterus | 100% | 2129.04 | 170 / 170 | 83% | 7.06 | 382 / 459 |
stomach | 100% | 2505.13 | 359 / 359 | 82% | 6.98 | 235 / 286 |
thymus | 99% | 1875.95 | 649 / 653 | 82% | 6.22 | 499 / 605 |
adrenal gland | 98% | 1146.34 | 253 / 258 | 83% | 6.91 | 191 / 230 |
kidney | 100% | 2327.85 | 89 / 89 | 78% | 5.96 | 704 / 901 |
bladder | 100% | 2928.90 | 21 / 21 | 78% | 6.12 | 393 / 504 |
pancreas | 72% | 746.52 | 237 / 328 | 85% | 4.19 | 151 / 178 |
skin | 95% | 4032.88 | 1715 / 1809 | 60% | 3.60 | 285 / 472 |
liver | 100% | 3119.78 | 226 / 226 | 54% | 2.35 | 220 / 406 |
adipose | 100% | 2226.78 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3160.45 | 1330 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 2355.76 | 797 / 803 | 0% | 0 | 0 / 0 |
spleen | 99% | 1132.97 | 238 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 8.53 | 42 / 45 |
heart | 75% | 746.85 | 642 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 50% | 2.04 | 40 / 80 |
peripheral blood | 46% | 1055.55 | 423 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 41% | 1.89 | 12 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0048675 | Biological process | axon extension |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0010592 | Biological process | positive regulation of lamellipodium assembly |
GO_0001764 | Biological process | neuron migration |
GO_0035022 | Biological process | positive regulation of Rac protein signal transduction |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0097484 | Biological process | dendrite extension |
GO_0005575 | Cellular component | cellular_component |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0030426 | Cellular component | growth cone |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
GO_0003682 | Molecular function | chromatin binding |
Gene name | AUTS2 |
Protein name | Autism susceptibility gene 2 protein Activator of transcription and developmental regulator AUTS2 (Autism susceptibility candidate 2, isoform CRA_a) Activator of transcription and developmental regulator AUTS2 Uncharacterized protein AUTS2 |
Synonyms | hCG_1983258 KIAA0442 |
Description | FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B . As a consequence, the complex mediates transcriptional activation . In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). . |
Accessions | H7C090 ENST00000664521.1 A0A2R8Y516 A0A2R8Y8C6 ENST00000656998.1 ENST00000700075.1 A0A590UK55 A0A087WVB5 Q75L24 ENST00000406775.6 [Q8WXX7-2] Q75MQ4 A0A8V8TPM5 A0A2R8Y522 A0A2R8YEX6 ENST00000443672.2 H7C2P0 ENST00000644506.1 Q75MQ7 ENST00000644949.1 Q75MD7 Q8WXX7 A0A590UJA2 ENST00000647140.1 A0A2R8Y6Q9 ENST00000342771.10 [Q8WXX7-1] ENST00000643936.1 Q75MQ3 ENST00000403018.3 [Q8WXX7-3] ENST00000659051.1 A0A590UJP3 A0A590UKA2 ENST00000644939.1 Q75L26 A0A024RDL5 ENST00000449547.6 ENST00000644359.1 ENST00000656200.1 ENST00000643587.1 ENST00000615871.4 A0A2R8Y568 ENST00000611706.4 ENST00000439256.2 H7C1G5 |