AUTS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048675Biological processaxon extension
GO_0030036Biological processactin cytoskeleton organization
GO_0010592Biological processpositive regulation of lamellipodium assembly
GO_0001764Biological processneuron migration
GO_0035022Biological processpositive regulation of Rac protein signal transduction
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0097484Biological processdendrite extension
GO_0005575Cellular componentcellular_component
GO_0015629Cellular componentactin cytoskeleton
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameAUTS2
Protein nameAutism susceptibility gene 2 protein
Activator of transcription and developmental regulator AUTS2 (Autism susceptibility candidate 2, isoform CRA_a)
Activator of transcription and developmental regulator AUTS2
Uncharacterized protein AUTS2
SynonymshCG_1983258
KIAA0442
DescriptionFUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B . As a consequence, the complex mediates transcriptional activation . In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). .

AccessionsH7C090
ENST00000664521.1
A0A2R8Y516
A0A2R8Y8C6
ENST00000656998.1
ENST00000700075.1
A0A590UK55
A0A087WVB5
Q75L24
ENST00000406775.6 [Q8WXX7-2]
Q75MQ4
A0A8V8TPM5
A0A2R8Y522
A0A2R8YEX6
ENST00000443672.2
H7C2P0
ENST00000644506.1
Q75MQ7
ENST00000644949.1
Q75MD7
Q8WXX7
A0A590UJA2
ENST00000647140.1
A0A2R8Y6Q9
ENST00000342771.10 [Q8WXX7-1]
ENST00000643936.1
Q75MQ3
ENST00000403018.3 [Q8WXX7-3]
ENST00000659051.1
A0A590UJP3
A0A590UKA2
ENST00000644939.1
Q75L26
A0A024RDL5
ENST00000449547.6
ENST00000644359.1
ENST00000656200.1
ENST00000643587.1
ENST00000615871.4
A0A2R8Y568
ENST00000611706.4
ENST00000439256.2
H7C1G5