ATP8B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140331Biological processaminophospholipid translocation
GO_0007605Biological processsensory perception of sound
GO_0006855Biological processxenobiotic transmembrane transport
GO_0008206Biological processbile acid metabolic process
GO_0021650Biological processvestibulocochlear nerve formation
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0045176Biological processapical protein localization
GO_0032534Biological processregulation of microvillus assembly
GO_0015721Biological processbile acid and bile salt transport
GO_0007030Biological processGolgi organization
GO_1903729Biological processregulation of plasma membrane organization
GO_0045332Biological processphospholipid translocation
GO_0060119Biological processinner ear receptor cell development
GO_2001225Biological processregulation of chloride transport
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0016324Cellular componentapical plasma membrane
GO_0032420Cellular componentstereocilium
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_1990531Cellular componentphospholipid-translocating ATPase complex
GO_0016604Cellular componentnuclear body
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0140345Molecular functionphosphatidylcholine flippase activity
GO_0090556Molecular functionphosphatidylserine floppase activity
GO_0090554Molecular functionphosphatidylcholine floppase activity
GO_0140326Molecular functionATPase-coupled intramembrane lipid transporter activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0140346Molecular functionphosphatidylserine flippase activity
GO_1901612Molecular functioncardiolipin binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP8B1
Protein namePhospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1)
Phospholipid-transporting ATPase (EC 7.6.2.1)
ATPase phospholipid transporting 8B1
SynonymsATPIC
FIC1
PFIC
DescriptionFUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane . May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity . Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 . Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine . Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity). .

AccessionsO43520
ENST00000591728.1
ENST00000642462.1
A0A3B3IRQ1
K7ESK2
ENST00000648039.1
A0A2R8Y5C5
ENST00000648908.2
ENST00000585322.2
ENST00000648467.1
K7EQC4