Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 22 studies | 28% ± 10% | |
epithelial cell | 10 studies | 37% ± 14% | |
smooth muscle cell | 9 studies | 29% ± 7% | |
goblet cell | 8 studies | 39% ± 23% | |
basal cell | 8 studies | 30% ± 15% | |
fibroblast | 8 studies | 25% ± 8% | |
ciliated cell | 8 studies | 27% ± 7% | |
club cell | 7 studies | 31% ± 13% | |
endothelial cell of lymphatic vessel | 7 studies | 35% ± 8% | |
pericyte | 7 studies | 25% ± 8% | |
transit amplifying cell | 6 studies | 29% ± 18% | |
glutamatergic neuron | 6 studies | 36% ± 20% | |
vein endothelial cell | 5 studies | 46% ± 30% | |
respiratory goblet cell | 5 studies | 43% ± 19% | |
microglial cell | 5 studies | 22% ± 4% | |
B cell | 5 studies | 30% ± 9% | |
type I pneumocyte | 5 studies | 26% ± 5% | |
type II pneumocyte | 5 studies | 29% ± 5% | |
macrophage | 5 studies | 21% ± 2% | |
secretory cell | 4 studies | 21% ± 3% | |
GABAergic neuron | 4 studies | 22% ± 4% | |
astrocyte | 4 studies | 30% ± 11% | |
brush cell | 4 studies | 19% ± 1% | |
squamous epithelial cell | 3 studies | 33% ± 22% | |
endothelial cell of artery | 3 studies | 24% ± 4% | |
adipocyte | 3 studies | 23% ± 3% | |
endothelial cell of vascular tree | 3 studies | 52% ± 22% | |
oligodendrocyte precursor cell | 3 studies | 20% ± 2% | |
alveolar macrophage | 3 studies | 21% ± 0% | |
monocyte | 3 studies | 27% ± 13% | |
neuron | 3 studies | 34% ± 23% | |
mast cell | 3 studies | 19% ± 2% | |
renal principal cell | 3 studies | 19% ± 3% | |
dendritic cell | 3 studies | 20% ± 3% | |
mucus secreting cell | 3 studies | 36% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 3515.65 | 245 / 245 | 100% | 53.28 | 500 / 502 |
stomach | 100% | 5817.45 | 359 / 359 | 99% | 62.70 | 282 / 286 |
esophagus | 100% | 2541.37 | 1443 / 1445 | 98% | 54.94 | 179 / 183 |
intestine | 99% | 6003.71 | 954 / 966 | 98% | 66.68 | 519 / 527 |
lung | 99% | 2384.81 | 574 / 578 | 97% | 36.93 | 1119 / 1155 |
pancreas | 100% | 3414.66 | 328 / 328 | 95% | 34.49 | 169 / 178 |
breast | 99% | 2293.73 | 456 / 459 | 95% | 48.09 | 1066 / 1118 |
bladder | 100% | 5783.76 | 21 / 21 | 95% | 52.10 | 477 / 504 |
thymus | 100% | 3004.73 | 652 / 653 | 88% | 28.94 | 533 / 605 |
uterus | 98% | 1892.74 | 167 / 170 | 82% | 30.93 | 378 / 459 |
liver | 88% | 926.36 | 200 / 226 | 71% | 15.56 | 290 / 406 |
kidney | 97% | 1246.65 | 86 / 89 | 57% | 9.20 | 511 / 901 |
adrenal gland | 99% | 1451.32 | 255 / 258 | 25% | 4.16 | 58 / 230 |
ovary | 33% | 395.64 | 60 / 180 | 77% | 15.38 | 332 / 430 |
skin | 100% | 2934.79 | 1806 / 1809 | 7% | 0.83 | 32 / 472 |
ureter | 0% | 0 | 0 / 0 | 100% | 18.58 | 1 / 1 |
blood vessel | 100% | 5288.66 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 2173.59 | 1189 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 30.89 | 41 / 45 |
spleen | 81% | 701.19 | 195 / 241 | 0% | 0 | 0 / 0 |
heart | 72% | 676.84 | 620 / 861 | 0% | 0 | 0 / 0 |
muscle | 14% | 102.43 | 110 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 8% | 1.03 | 6 / 80 |
brain | 3% | 19.45 | 71 / 2642 | 1% | 0.11 | 6 / 705 |
peripheral blood | 1% | 5.13 | 6 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0140331 | Biological process | aminophospholipid translocation |
GO_0007605 | Biological process | sensory perception of sound |
GO_0006855 | Biological process | xenobiotic transmembrane transport |
GO_0008206 | Biological process | bile acid metabolic process |
GO_0021650 | Biological process | vestibulocochlear nerve formation |
GO_0034220 | Biological process | monoatomic ion transmembrane transport |
GO_0045176 | Biological process | apical protein localization |
GO_0032534 | Biological process | regulation of microvillus assembly |
GO_0015721 | Biological process | bile acid and bile salt transport |
GO_0007030 | Biological process | Golgi organization |
GO_1903729 | Biological process | regulation of plasma membrane organization |
GO_0045332 | Biological process | phospholipid translocation |
GO_0060119 | Biological process | inner ear receptor cell development |
GO_2001225 | Biological process | regulation of chloride transport |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0032420 | Cellular component | stereocilium |
GO_0005886 | Cellular component | plasma membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005802 | Cellular component | trans-Golgi network |
GO_1990531 | Cellular component | phospholipid-translocating ATPase complex |
GO_0016604 | Cellular component | nuclear body |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0140345 | Molecular function | phosphatidylcholine flippase activity |
GO_0090556 | Molecular function | phosphatidylserine floppase activity |
GO_0090554 | Molecular function | phosphatidylcholine floppase activity |
GO_0140326 | Molecular function | ATPase-coupled intramembrane lipid transporter activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0140346 | Molecular function | phosphatidylserine flippase activity |
GO_1901612 | Molecular function | cardiolipin binding |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | ATP8B1 |
Protein name | Phospholipid-transporting ATPase IC (EC 7.6.2.1) (ATPase class I type 8B member 1) (Familial intrahepatic cholestasis type 1) (P4-ATPase flippase complex alpha subunit ATP8B1) Phospholipid-transporting ATPase (EC 7.6.2.1) ATPase phospholipid transporting 8B1 |
Synonyms | ATPIC FIC1 PFIC |
Description | FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane . May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity . Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 . Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with TMEM30A is involved in uptake of the synthetic drug alkylphospholipid perifosine . Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity). . |
Accessions | O43520 ENST00000591728.1 ENST00000642462.1 A0A3B3IRQ1 K7ESK2 ENST00000648039.1 A0A2R8Y5C5 ENST00000648908.2 ENST00000585322.2 ENST00000648467.1 K7EQC4 |