ATP2A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010882Biological processregulation of cardiac muscle contraction by calcium ion signaling
GO_0008544Biological processepidermis development
GO_0140056Biological processorganelle localization by membrane tethering
GO_0098909Biological processregulation of cardiac muscle cell action potential involved in regulation of contraction
GO_0070296Biological processsarcoplasmic reticulum calcium ion transport
GO_0032470Biological processpositive regulation of endoplasmic reticulum calcium ion concentration
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0000045Biological processautophagosome assembly
GO_0014898Biological processcardiac muscle hypertrophy in response to stress
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0002026Biological processregulation of the force of heart contraction
GO_0007155Biological processcell adhesion
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0010666Biological processpositive regulation of cardiac muscle cell apoptotic process
GO_1990036Biological processcalcium ion import into sarcoplasmic reticulum
GO_0016240Biological processautophagosome membrane docking
GO_0045822Biological processnegative regulation of heart contraction
GO_0014883Biological processtransition between fast and slow fiber
GO_0070050Biological processneuron cellular homeostasis
GO_0034599Biological processcellular response to oxidative stress
GO_0033292Biological processT-tubule organization
GO_1903233Biological processregulation of calcium ion-dependent exocytosis of neurotransmitter
GO_1900121Biological processnegative regulation of receptor binding
GO_1903779Biological processregulation of cardiac conduction
GO_0086036Biological processregulation of cardiac muscle cell membrane potential
GO_0006984Biological processER-nucleus signaling pathway
GO_0032469Biological processendoplasmic reticulum calcium ion homeostasis
GO_0010460Biological processpositive regulation of heart rate
GO_0070588Biological processcalcium ion transmembrane transport
GO_1903515Biological processcalcium ion transport from cytosol to endoplasmic reticulum
GO_1990456Biological processmitochondrion-endoplasmic reticulum membrane tethering
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031095Cellular componentplatelet dense tubular network membrane
GO_0097470Cellular componentribbon synapse
GO_0005783Cellular componentendoplasmic reticulum
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0033017Cellular componentsarcoplasmic reticulum membrane
GO_0019899Molecular functionenzyme binding
GO_0005388Molecular functionP-type calcium transporter activity
GO_0106222Molecular functionlncRNA binding
GO_0005524Molecular functionATP binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0086039Molecular functionP-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
GO_0044548Molecular functionS100 protein binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP2A2
Protein nameATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
SERCA Ca(2+)-ATPase
ATPase CA++ transporting cardiac muscle slow twitch 2
P-type Ca(2+) transporter (EC 7.2.2.10)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
ATPase Ca++ transporting cardiac muscle slow twitch 2 isoform 2
ATPase Ca++ transporting cardiac muscle slow twitch 2 isoform 3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
SynonymsATP2B
hCG_39049
DescriptionFUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen . Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation . Also modulates ER contacts with lipid droplets, mitochondria and endosomes . In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). .; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. .

AccessionsENST00000553144.1
A0A0C4DH86
ENST00000552636.2
F8W1Z7
H7C5W9
P16615
ENST00000539276.7 [P16615-1]
B0FYL2
J3QSY6
ENST00000548169.2
A0A0S2Z425
A0A0S2Z3H0
ENST00000308664.10 [P16615-2]
ENST00000377685.9
B1PM99
A0A0S2Z3L2