Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 23 studies | 24% ± 8% | |
endothelial cell | 22 studies | 29% ± 12% | |
smooth muscle cell | 22 studies | 27% ± 10% | |
ciliated cell | 19 studies | 52% ± 18% | |
fibroblast | 16 studies | 28% ± 11% | |
basal cell | 15 studies | 31% ± 10% | |
astrocyte | 15 studies | 33% ± 13% | |
pericyte | 14 studies | 25% ± 14% | |
oligodendrocyte precursor cell | 13 studies | 34% ± 16% | |
epithelial cell | 11 studies | 35% ± 21% | |
glutamatergic neuron | 11 studies | 51% ± 23% | |
oligodendrocyte | 11 studies | 30% ± 10% | |
GABAergic neuron | 10 studies | 43% ± 23% | |
microglial cell | 10 studies | 28% ± 8% | |
myeloid cell | 9 studies | 33% ± 11% | |
club cell | 8 studies | 25% ± 6% | |
adipocyte | 8 studies | 23% ± 9% | |
monocyte | 7 studies | 23% ± 4% | |
respiratory goblet cell | 7 studies | 27% ± 8% | |
secretory cell | 7 studies | 26% ± 10% | |
classical monocyte | 7 studies | 24% ± 7% | |
neuron | 7 studies | 39% ± 12% | |
goblet cell | 7 studies | 28% ± 8% | |
cardiac muscle cell | 7 studies | 67% ± 25% | |
mast cell | 6 studies | 23% ± 12% | |
type I pneumocyte | 6 studies | 22% ± 7% | |
interneuron | 6 studies | 48% ± 26% | |
myofibroblast cell | 6 studies | 22% ± 8% | |
dendritic cell | 6 studies | 25% ± 11% | |
hepatocyte | 5 studies | 40% ± 23% | |
connective tissue cell | 5 studies | 19% ± 2% | |
deuterosomal cell | 4 studies | 26% ± 8% | |
squamous epithelial cell | 4 studies | 40% ± 20% | |
conventional dendritic cell | 4 studies | 28% ± 12% | |
hematopoietic precursor cell | 4 studies | 29% ± 4% | |
abnormal cell | 4 studies | 27% ± 14% | |
transit amplifying cell | 4 studies | 32% ± 21% | |
granule cell | 4 studies | 23% ± 5% | |
retinal ganglion cell | 4 studies | 51% ± 18% | |
amacrine cell | 4 studies | 21% ± 4% | |
retina horizontal cell | 4 studies | 24% ± 5% | |
mesothelial cell | 4 studies | 20% ± 3% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 19% ± 4% | |
muscle cell | 4 studies | 50% ± 28% | |
type II pneumocyte | 4 studies | 24% ± 8% | |
hillock cell | 3 studies | 32% ± 4% | |
ionocyte | 3 studies | 38% ± 5% | |
T cell | 3 studies | 26% ± 14% | |
non-classical monocyte | 3 studies | 26% ± 7% | |
GABAergic interneuron | 3 studies | 37% ± 6% | |
plasma cell | 3 studies | 33% ± 11% | |
retinal cone cell | 3 studies | 19% ± 1% | |
retinal pigment epithelial cell | 3 studies | 29% ± 6% | |
serous secreting cell | 3 studies | 21% ± 8% | |
lymphocyte | 3 studies | 30% ± 10% | |
ON-bipolar cell | 3 studies | 17% ± 1% | |
erythroblast | 3 studies | 25% ± 3% | |
endothelial cell of artery | 3 studies | 18% ± 2% | |
ependymal cell | 3 studies | 30% ± 13% | |
enteroendocrine cell | 3 studies | 30% ± 5% | |
alveolar macrophage | 3 studies | 33% ± 10% | |
luminal cell of prostate epithelium | 3 studies | 22% ± 4% | |
mucus secreting cell | 3 studies | 30% ± 10% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 18 studies | 36% ± 20% | |
lung | 10 studies | 25% ± 9% | |
heart | 6 studies | 36% ± 17% | |
eye | 4 studies | 26% ± 9% | |
liver | 4 studies | 30% ± 14% | |
intestine | 4 studies | 19% ± 3% | |
peripheral blood | 3 studies | 20% ± 1% | |
uterus | 3 studies | 29% ± 14% | |
adipose | 3 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 17539.34 | 1444 / 1445 | 100% | 148.04 | 183 / 183 |
skin | 100% | 16069.67 | 1803 / 1809 | 100% | 97.34 | 470 / 472 |
intestine | 100% | 12166.59 | 963 / 966 | 99% | 93.69 | 524 / 527 |
bladder | 100% | 16783.86 | 21 / 21 | 99% | 86.81 | 497 / 504 |
lung | 98% | 11828.30 | 569 / 578 | 100% | 116.36 | 1153 / 1155 |
breast | 99% | 9776.79 | 453 / 459 | 99% | 80.52 | 1105 / 1118 |
prostate | 99% | 14805.24 | 243 / 245 | 97% | 67.44 | 489 / 502 |
uterus | 98% | 9850.84 | 167 / 170 | 98% | 101.73 | 451 / 459 |
thymus | 99% | 12164.80 | 649 / 653 | 97% | 61.47 | 584 / 605 |
ovary | 96% | 10050.03 | 173 / 180 | 100% | 67.27 | 429 / 430 |
brain | 96% | 16286.66 | 2531 / 2642 | 100% | 106.38 | 705 / 705 |
adrenal gland | 98% | 11090.89 | 253 / 258 | 93% | 51.55 | 214 / 230 |
stomach | 91% | 7841.53 | 325 / 359 | 100% | 97.83 | 285 / 286 |
liver | 86% | 8832.71 | 195 / 226 | 93% | 49.52 | 377 / 406 |
pancreas | 69% | 4372.49 | 227 / 328 | 98% | 73.12 | 175 / 178 |
kidney | 62% | 4983.74 | 55 / 89 | 98% | 66.27 | 881 / 901 |
muscle | 100% | 232534.74 | 803 / 803 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 51.78 | 1 / 1 |
blood vessel | 100% | 21386.67 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 10900.60 | 1199 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 62.84 | 79 / 80 |
tonsil | 0% | 0 | 0 / 0 | 98% | 120.77 | 44 / 45 |
heart | 97% | 135925.55 | 834 / 861 | 0% | 0 | 0 / 0 |
spleen | 87% | 5634.93 | 209 / 241 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 69% | 39.32 | 20 / 29 |
peripheral blood | 23% | 3198.15 | 216 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010882 | Biological process | regulation of cardiac muscle contraction by calcium ion signaling |
GO_0008544 | Biological process | epidermis development |
GO_0140056 | Biological process | organelle localization by membrane tethering |
GO_0098909 | Biological process | regulation of cardiac muscle cell action potential involved in regulation of contraction |
GO_0070296 | Biological process | sarcoplasmic reticulum calcium ion transport |
GO_0032470 | Biological process | positive regulation of endoplasmic reticulum calcium ion concentration |
GO_0034976 | Biological process | response to endoplasmic reticulum stress |
GO_0000045 | Biological process | autophagosome assembly |
GO_0014898 | Biological process | cardiac muscle hypertrophy in response to stress |
GO_0034220 | Biological process | monoatomic ion transmembrane transport |
GO_0002026 | Biological process | regulation of the force of heart contraction |
GO_0007155 | Biological process | cell adhesion |
GO_0006874 | Biological process | intracellular calcium ion homeostasis |
GO_0010666 | Biological process | positive regulation of cardiac muscle cell apoptotic process |
GO_1990036 | Biological process | calcium ion import into sarcoplasmic reticulum |
GO_0016240 | Biological process | autophagosome membrane docking |
GO_0045822 | Biological process | negative regulation of heart contraction |
GO_0014883 | Biological process | transition between fast and slow fiber |
GO_0070050 | Biological process | neuron cellular homeostasis |
GO_0034599 | Biological process | cellular response to oxidative stress |
GO_0033292 | Biological process | T-tubule organization |
GO_1903233 | Biological process | regulation of calcium ion-dependent exocytosis of neurotransmitter |
GO_1900121 | Biological process | negative regulation of receptor binding |
GO_1903779 | Biological process | regulation of cardiac conduction |
GO_0086036 | Biological process | regulation of cardiac muscle cell membrane potential |
GO_0006984 | Biological process | ER-nucleus signaling pathway |
GO_0032469 | Biological process | endoplasmic reticulum calcium ion homeostasis |
GO_0010460 | Biological process | positive regulation of heart rate |
GO_0070588 | Biological process | calcium ion transmembrane transport |
GO_1903515 | Biological process | calcium ion transport from cytosol to endoplasmic reticulum |
GO_1990456 | Biological process | mitochondrion-endoplasmic reticulum membrane tethering |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0031095 | Cellular component | platelet dense tubular network membrane |
GO_0097470 | Cellular component | ribbon synapse |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0016529 | Cellular component | sarcoplasmic reticulum |
GO_0033017 | Cellular component | sarcoplasmic reticulum membrane |
GO_0019899 | Molecular function | enzyme binding |
GO_0005388 | Molecular function | P-type calcium transporter activity |
GO_0106222 | Molecular function | lncRNA binding |
GO_0005524 | Molecular function | ATP binding |
GO_0044325 | Molecular function | transmembrane transporter binding |
GO_0086039 | Molecular function | P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential |
GO_0044548 | Molecular function | S100 protein binding |
GO_0005509 | Molecular function | calcium ion binding |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | ATP2A2 |
Protein name | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 SERCA Ca(2+)-ATPase ATPase CA++ transporting cardiac muscle slow twitch 2 P-type Ca(2+) transporter (EC 7.2.2.10) Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) ATPase Ca++ transporting cardiac muscle slow twitch 2 isoform 2 ATPase Ca++ transporting cardiac muscle slow twitch 2 isoform 3 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) |
Synonyms | ATP2B hCG_39049 |
Description | FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen . Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation . Also modulates ER contacts with lipid droplets, mitochondria and endosomes . In coordination with FLVCR2 mediates heme-stimulated switching from mitochondrial ATP synthesis to thermogenesis (By similarity). .; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. . |
Accessions | ENST00000553144.1 A0A0C4DH86 ENST00000552636.2 F8W1Z7 H7C5W9 P16615 ENST00000539276.7 [P16615-1] B0FYL2 J3QSY6 ENST00000548169.2 A0A0S2Z425 A0A0S2Z3H0 ENST00000308664.10 [P16615-2] ENST00000377685.9 B1PM99 A0A0S2Z3L2 |