ATP11A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140331Biological processaminophospholipid translocation
GO_0097035Biological processregulation of membrane lipid distribution
GO_0001701Biological processin utero embryonic development
GO_0010831Biological processpositive regulation of myotube differentiation
GO_0045332Biological processphospholipid translocation
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005769Cellular componentearly endosome
GO_0005794Cellular componentGolgi apparatus
GO_1990531Cellular componentphospholipid-translocating ATPase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0070821Cellular componenttertiary granule membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005765Cellular componentlysosomal membrane
GO_0090556Molecular functionphosphatidylserine floppase activity
GO_0140326Molecular functionATPase-coupled intramembrane lipid transporter activity
GO_0000287Molecular functionmagnesium ion binding
GO_0090555Molecular functionphosphatidylethanolamine flippase activity
GO_0005524Molecular functionATP binding
GO_0140346Molecular functionphosphatidylserine flippase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP11A
Protein namePhospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A)
Alternative protein ATP11A
Phospholipid-transporting ATPase (EC 7.6.2.1)
ATPase phospholipid transporting 11A
SynonymsATPIH
ATPIS
KIAA1021
DescriptionFUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane . Does not show flippase activity toward phosphatidylcholine (PC) . Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation . May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. .

AccessionsA2A3G9
A0A087WVE8
E9PEJ6
P98196
H0Y8F0
ENST00000610419.1
H0Y547
ENST00000415301.2
L8EAS3
L8E8N1
Q6PJ25
ENST00000375630.6
ENST00000419631.1
H0Y624
ENST00000471555.5
ENST00000375645.8
ENST00000487903.5
ENST00000418678.5