Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 24 studies | 33% ± 14% | |
oligodendrocyte | 14 studies | 39% ± 16% | |
type I pneumocyte | 12 studies | 56% ± 20% | |
type II pneumocyte | 12 studies | 56% ± 23% | |
macrophage | 11 studies | 33% ± 16% | |
microglial cell | 10 studies | 37% ± 14% | |
endothelial cell of lymphatic vessel | 9 studies | 36% ± 18% | |
myeloid cell | 9 studies | 29% ± 10% | |
retinal cone cell | 7 studies | 42% ± 17% | |
fibroblast | 7 studies | 27% ± 7% | |
epithelial cell | 6 studies | 43% ± 15% | |
astrocyte | 6 studies | 27% ± 10% | |
classical monocyte | 5 studies | 28% ± 11% | |
interneuron | 5 studies | 30% ± 16% | |
neuron | 5 studies | 36% ± 18% | |
oligodendrocyte precursor cell | 5 studies | 27% ± 10% | |
cardiac muscle cell | 5 studies | 37% ± 9% | |
dendritic cell | 5 studies | 26% ± 8% | |
GABAergic neuron | 5 studies | 37% ± 15% | |
glutamatergic neuron | 5 studies | 42% ± 21% | |
monocyte | 5 studies | 43% ± 9% | |
non-classical monocyte | 4 studies | 30% ± 12% | |
pericyte | 4 studies | 23% ± 5% | |
retinal rod cell | 4 studies | 28% ± 7% | |
endothelial cell of vascular tree | 4 studies | 30% ± 22% | |
club cell | 4 studies | 43% ± 10% | |
abnormal cell | 3 studies | 31% ± 16% | |
retinal ganglion cell | 3 studies | 24% ± 9% | |
mesothelial cell | 3 studies | 43% ± 12% | |
vein endothelial cell | 3 studies | 42% ± 23% | |
OFF-bipolar cell | 3 studies | 26% ± 13% | |
retinal pigment epithelial cell | 3 studies | 29% ± 12% | |
alveolar macrophage | 3 studies | 42% ± 14% | |
smooth muscle cell | 3 studies | 21% ± 7% | |
lymphocyte | 3 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2271.55 | 1444 / 1445 | 98% | 38.85 | 180 / 183 |
intestine | 100% | 2216.29 | 962 / 966 | 95% | 27.04 | 500 / 527 |
lung | 100% | 12118.11 | 578 / 578 | 93% | 49.48 | 1069 / 1155 |
kidney | 100% | 3763.74 | 89 / 89 | 91% | 59.93 | 817 / 901 |
brain | 99% | 2544.93 | 2606 / 2642 | 92% | 16.44 | 647 / 705 |
thymus | 100% | 6242.23 | 653 / 653 | 89% | 53.48 | 540 / 605 |
stomach | 91% | 1628.65 | 327 / 359 | 97% | 36.01 | 276 / 286 |
pancreas | 99% | 2738.85 | 325 / 328 | 88% | 21.07 | 157 / 178 |
skin | 100% | 3482.10 | 1808 / 1809 | 79% | 20.10 | 372 / 472 |
uterus | 100% | 5225.63 | 170 / 170 | 71% | 12.38 | 324 / 459 |
bladder | 100% | 2098.33 | 21 / 21 | 63% | 14.45 | 315 / 504 |
prostate | 99% | 1735.67 | 242 / 245 | 63% | 14.87 | 318 / 502 |
ovary | 100% | 2952.39 | 180 / 180 | 59% | 10.09 | 254 / 430 |
liver | 100% | 2457.89 | 226 / 226 | 52% | 9.29 | 213 / 406 |
breast | 100% | 2949.10 | 459 / 459 | 51% | 7.30 | 571 / 1118 |
adrenal gland | 100% | 4593.03 | 258 / 258 | 37% | 4.42 | 84 / 230 |
adipose | 100% | 3974.21 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 2372.52 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3413.98 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 99% | 4663.23 | 849 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 3912.58 | 897 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 96% | 1620.97 | 1284 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 21.98 | 71 / 80 |
lymph node | 0% | 0 | 0 / 0 | 52% | 6.91 | 15 / 29 |
tonsil | 0% | 0 | 0 / 0 | 47% | 6.30 | 21 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0140331 | Biological process | aminophospholipid translocation |
GO_0097035 | Biological process | regulation of membrane lipid distribution |
GO_0001701 | Biological process | in utero embryonic development |
GO_0010831 | Biological process | positive regulation of myotube differentiation |
GO_0045332 | Biological process | phospholipid translocation |
GO_0035579 | Cellular component | specific granule membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0055037 | Cellular component | recycling endosome |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005769 | Cellular component | early endosome |
GO_0005794 | Cellular component | Golgi apparatus |
GO_1990531 | Cellular component | phospholipid-translocating ATPase complex |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0070821 | Cellular component | tertiary granule membrane |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0090556 | Molecular function | phosphatidylserine floppase activity |
GO_0140326 | Molecular function | ATPase-coupled intramembrane lipid transporter activity |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0090555 | Molecular function | phosphatidylethanolamine flippase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0140346 | Molecular function | phosphatidylserine flippase activity |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | ATP11A |
Protein name | Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A) Alternative protein ATP11A Phospholipid-transporting ATPase (EC 7.6.2.1) ATPase phospholipid transporting 11A |
Synonyms | ATPIH ATPIS KIAA1021 |
Description | FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane . Does not show flippase activity toward phosphatidylcholine (PC) . Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation . May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib. . |
Accessions | A2A3G9 A0A087WVE8 E9PEJ6 P98196 H0Y8F0 ENST00000610419.1 H0Y547 ENST00000415301.2 L8EAS3 L8E8N1 Q6PJ25 ENST00000375630.6 ENST00000419631.1 H0Y624 ENST00000471555.5 ENST00000375645.8 ENST00000487903.5 ENST00000418678.5 |