AKAP8L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010793Biological processregulation of mRNA export from nucleus
GO_0006397Biological processmRNA processing
GO_0008380Biological processRNA splicing
GO_0051081Biological processnuclear membrane disassembly
GO_0007076Biological processmitotic chromosome condensation
GO_0044839Biological processcell cycle G2/M phase transition
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0034237Molecular functionprotein kinase A regulatory subunit binding
GO_0005521Molecular functionlamin binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0017151Molecular functionDEAD/H-box RNA helicase binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameAKAP8L
Protein nameA kinase (PRKA) anchor protein 8-like, isoform CRA_c (A-kinase anchoring protein 8 like)
A-kinase anchoring protein 8 like
A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95)
A kinase (PRKA) anchor protein 8-like, isoform CRA_d (cDNA FLJ10732 fis, clone NT2RP3001384, highly similar to A-kinase anchor protein 8)
SynonymsNAKAP
hCG_36782
HRIHFB2018
NAKAP95
DescriptionFUNCTION: Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export . Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA . May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis . May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 . May be involved in regulation of pre-mRNA splicing . .; FUNCTION: (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. .; FUNCTION: (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. .; FUNCTION: (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. .

AccessionsM0R008
ENST00000680649.1
ENST00000680017.1
ENST00000599137.6
ENST00000595067.1
ENST00000680803.1
ENST00000594594.6
A0A7P0TAD3
V9GZ50
Q9ULX6
A0A7P0T8N3
A0A7P0TAJ5
ENST00000596195.5
ENST00000600247.5
M0R010
ENST00000680642.1
A0A7P0TAE3
A0A7P0T9N5
ENST00000397410.10 [Q9ULX6-1]
M0R1L5
A0A7P0TBP0
A0A7P0T847
ENST00000595465.6 [Q9ULX6-2]
M0QYT7
ENST00000680363.1
M0R1Y5
ENST00000679638.1
ENST00000609519.5
ENST00000680303.1
ENST00000681459.1
ENST00000681170.1
B3KMD4