Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 26% ± 10% | |
astrocyte | 12 studies | 27% ± 11% | |
glutamatergic neuron | 10 studies | 38% ± 23% | |
oligodendrocyte | 8 studies | 21% ± 7% | |
adipocyte | 7 studies | 22% ± 3% | |
GABAergic neuron | 7 studies | 35% ± 21% | |
pericyte | 7 studies | 21% ± 4% | |
macrophage | 6 studies | 22% ± 5% | |
epithelial cell | 6 studies | 35% ± 12% | |
smooth muscle cell | 6 studies | 19% ± 3% | |
fibroblast | 6 studies | 22% ± 4% | |
B cell | 5 studies | 20% ± 4% | |
neuron | 5 studies | 30% ± 9% | |
interneuron | 5 studies | 33% ± 19% | |
oligodendrocyte precursor cell | 5 studies | 26% ± 7% | |
retinal cone cell | 5 studies | 20% ± 5% | |
retinal rod cell | 5 studies | 21% ± 2% | |
ciliated cell | 5 studies | 27% ± 11% | |
granule cell | 4 studies | 24% ± 9% | |
microglial cell | 4 studies | 24% ± 5% | |
retina horizontal cell | 4 studies | 21% ± 3% | |
cardiac muscle cell | 4 studies | 20% ± 2% | |
basal cell | 4 studies | 23% ± 6% | |
abnormal cell | 4 studies | 21% ± 8% | |
goblet cell | 4 studies | 24% ± 12% | |
natural killer cell | 3 studies | 21% ± 4% | |
GABAergic interneuron | 3 studies | 21% ± 4% | |
amacrine cell | 3 studies | 29% ± 8% | |
lymphocyte | 3 studies | 22% ± 2% | |
myeloid cell | 3 studies | 16% ± 1% | |
hepatocyte | 3 studies | 33% ± 15% | |
myofibroblast cell | 3 studies | 22% ± 1% | |
endothelial cell of lymphatic vessel | 3 studies | 19% ± 1% | |
monocyte | 3 studies | 17% ± 2% | |
type II pneumocyte | 3 studies | 20% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
pancreas | 100% | 2606.65 | 328 / 328 | 100% | 20.61 | 178 / 178 |
prostate | 100% | 7081.93 | 245 / 245 | 100% | 22.02 | 502 / 502 |
uterus | 100% | 5251.91 | 170 / 170 | 100% | 22.56 | 459 / 459 |
skin | 100% | 3880.61 | 1808 / 1809 | 100% | 19.79 | 472 / 472 |
breast | 100% | 4748.58 | 459 / 459 | 100% | 22.98 | 1117 / 1118 |
thymus | 100% | 7553.89 | 653 / 653 | 100% | 23.46 | 604 / 605 |
ovary | 100% | 5110.01 | 180 / 180 | 100% | 29.89 | 429 / 430 |
brain | 100% | 4994.33 | 2637 / 2642 | 100% | 28.88 | 704 / 705 |
stomach | 100% | 3414.11 | 359 / 359 | 100% | 14.41 | 285 / 286 |
bladder | 100% | 4371.62 | 21 / 21 | 100% | 20.46 | 502 / 504 |
lung | 100% | 4648.94 | 578 / 578 | 100% | 16.61 | 1150 / 1155 |
esophagus | 100% | 3763.42 | 1445 / 1445 | 99% | 14.78 | 182 / 183 |
intestine | 100% | 4651.33 | 966 / 966 | 99% | 15.97 | 523 / 527 |
adrenal gland | 100% | 5988.13 | 258 / 258 | 99% | 27.00 | 228 / 230 |
kidney | 100% | 5065.00 | 89 / 89 | 99% | 15.94 | 888 / 901 |
liver | 100% | 3191.95 | 226 / 226 | 98% | 13.07 | 399 / 406 |
adipose | 100% | 3954.51 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 16.89 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 22.04 | 29 / 29 |
muscle | 100% | 3886.11 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 6396.01 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 17.42 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 16.32 | 1 / 1 |
blood vessel | 100% | 3962.72 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 3726.36 | 924 / 929 | 0% | 0 | 0 / 0 |
heart | 99% | 3195.36 | 854 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010793 | Biological process | regulation of mRNA export from nucleus |
GO_0006397 | Biological process | mRNA processing |
GO_0008380 | Biological process | RNA splicing |
GO_0051081 | Biological process | nuclear membrane disassembly |
GO_0007076 | Biological process | mitotic chromosome condensation |
GO_0044839 | Biological process | cell cycle G2/M phase transition |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0016607 | Cellular component | nuclear speck |
GO_0005654 | Cellular component | nucleoplasm |
GO_0016363 | Cellular component | nuclear matrix |
GO_0016605 | Cellular component | PML body |
GO_0005737 | Cellular component | cytoplasm |
GO_1990904 | Cellular component | ribonucleoprotein complex |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0034237 | Molecular function | protein kinase A regulatory subunit binding |
GO_0005521 | Molecular function | lamin binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0003723 | Molecular function | RNA binding |
GO_0017151 | Molecular function | DEAD/H-box RNA helicase binding |
GO_0005515 | Molecular function | protein binding |
GO_0042826 | Molecular function | histone deacetylase binding |
Gene name | AKAP8L |
Protein name | A kinase (PRKA) anchor protein 8-like, isoform CRA_c (A-kinase anchoring protein 8 like) A-kinase anchoring protein 8 like A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95) A kinase (PRKA) anchor protein 8-like, isoform CRA_d (cDNA FLJ10732 fis, clone NT2RP3001384, highly similar to A-kinase anchor protein 8) |
Synonyms | NAKAP hCG_36782 HRIHFB2018 NAKAP95 |
Description | FUNCTION: Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export . Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA . May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis . May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 . May be involved in regulation of pre-mRNA splicing . .; FUNCTION: (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. .; FUNCTION: (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. .; FUNCTION: (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. . |
Accessions | M0R008 ENST00000680649.1 ENST00000680017.1 ENST00000599137.6 ENST00000595067.1 ENST00000680803.1 ENST00000594594.6 A0A7P0TAD3 V9GZ50 Q9ULX6 A0A7P0T8N3 A0A7P0TAJ5 ENST00000596195.5 ENST00000600247.5 M0R010 ENST00000680642.1 A0A7P0TAE3 A0A7P0T9N5 ENST00000397410.10 [Q9ULX6-1] M0R1L5 A0A7P0TBP0 A0A7P0T847 ENST00000595465.6 [Q9ULX6-2] M0QYT7 ENST00000680363.1 M0R1Y5 ENST00000679638.1 ENST00000609519.5 ENST00000680303.1 ENST00000681459.1 ENST00000681170.1 B3KMD4 |