ADI1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	29 studies	28% ± 13%	Explore
smooth muscle cell	22 studies	28% ± 8%	Explore
pericyte	21 studies	29% ± 8%	Explore
basal cell	15 studies	29% ± 17%	Explore
macrophage	15 studies	26% ± 10%	Explore
plasmacytoid dendritic cell	15 studies	30% ± 11%	Explore
endothelial cell	14 studies	25% ± 8%	Explore
conventional dendritic cell	13 studies	26% ± 15%	Explore
epithelial cell	13 studies	40% ± 21%	Explore
endothelial cell of lymphatic vessel	11 studies	24% ± 7%	Explore
non-classical monocyte	11 studies	28% ± 12%	Explore
CD4-positive, alpha-beta T cell	11 studies	21% ± 5%	Explore
connective tissue cell	11 studies	26% ± 4%	Explore
classical monocyte	10 studies	27% ± 9%	Explore
myofibroblast cell	10 studies	25% ± 7%	Explore
plasma cell	9 studies	33% ± 10%	Explore
secretory cell	9 studies	29% ± 17%	Explore
type I pneumocyte	8 studies	31% ± 12%	Explore
B cell	8 studies	20% ± 8%	Explore
abnormal cell	8 studies	29% ± 9%	Explore
mesothelial cell	8 studies	39% ± 13%	Explore
type II pneumocyte	7 studies	41% ± 16%	Explore
platelet	7 studies	23% ± 4%	Explore
monocyte	7 studies	22% ± 4%	Explore
regulatory T cell	7 studies	21% ± 4%	Explore
mast cell	6 studies	21% ± 5%	Explore
plasmablast	6 studies	35% ± 22%	Explore
club cell	6 studies	30% ± 3%	Explore
ionocyte	6 studies	38% ± 9%	Explore
epithelial cell of proximal tubule	6 studies	59% ± 19%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 15%	Explore
renal alpha-intercalated cell	6 studies	53% ± 15%	Explore
natural killer cell	6 studies	21% ± 5%	Explore
enterocyte	6 studies	28% ± 6%	Explore
astrocyte	6 studies	30% ± 13%	Explore
hepatocyte	6 studies	47% ± 27%	Explore
respiratory goblet cell	5 studies	26% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	18% ± 2%	Explore
dendritic cell	5 studies	39% ± 19%	Explore
endothelial cell of artery	5 studies	19% ± 3%	Explore
T follicular helper cell	5 studies	18% ± 2%	Explore
goblet cell	5 studies	27% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	36% ± 17%	Explore
transit amplifying cell	4 studies	20% ± 3%	Explore
endothelial cell of vascular tree	4 studies	24% ± 12%	Explore
myeloid cell	4 studies	26% ± 11%	Explore
adventitial cell	4 studies	37% ± 5%	Explore
ciliated cell	4 studies	46% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	19% ± 4%	Explore
duct epithelial cell	3 studies	33% ± 3%	Explore
mononuclear phagocyte	3 studies	31% ± 18%	Explore
hematopoietic precursor cell	3 studies	30% ± 7%	Explore
progenitor cell	3 studies	21% ± 2%	Explore
leukocyte	3 studies	24% ± 5%	Explore
placental villous trophoblast	3 studies	67% ± 13%	Explore
lymphocyte	3 studies	25% ± 8%	Explore
megakaryocyte	3 studies	29% ± 8%	Explore
neuroendocrine cell	3 studies	31% ± 3%	Explore
pro-B cell	3 studies	22% ± 3%	Explore
serous secreting cell	3 studies	43% ± 12%	Explore
Mueller cell	3 studies	33% ± 7%	Explore
intermediate monocyte	3 studies	30% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	37% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
glial cell	3 studies	25% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	21% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	18% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	25% ± 14%	Explore
intestine	8 studies	22% ± 9%	Explore
kidney	7 studies	31% ± 14%	Explore
peripheral blood	6 studies	22% ± 6%	Explore
liver	5 studies	37% ± 13%	Explore
uterus	4 studies	30% ± 13%	Explore
brain	4 studies	20% ± 5%	Explore
placenta	3 studies	35% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	20887.95	226 / 226	100%	181.57	406 / 406
ovary	100%	4813.35	180 / 180	100%	53.23	430 / 430
prostate	100%	8207.72	245 / 245	100%	164.16	502 / 502
kidney	100%	11081.56	89 / 89	100%	63.09	899 / 901
stomach	100%	6194.93	358 / 359	100%	46.84	286 / 286
lung	100%	4571.29	576 / 578	100%	65.40	1155 / 1155
skin	100%	3922.93	1805 / 1809	100%	56.19	471 / 472
uterus	100%	4173.92	170 / 170	100%	63.08	457 / 459
intestine	100%	5172.07	965 / 966	100%	55.49	525 / 527
esophagus	100%	5079.75	1444 / 1445	99%	34.55	182 / 183
thymus	100%	4087.60	651 / 653	100%	50.50	602 / 605
brain	99%	3236.02	2622 / 2642	100%	43.97	704 / 705
bladder	100%	5279.24	21 / 21	99%	60.31	499 / 504
adrenal gland	100%	7357.24	258 / 258	99%	57.41	227 / 230
breast	100%	4685.42	459 / 459	98%	44.18	1092 / 1118
pancreas	97%	1992.12	317 / 328	98%	44.25	175 / 178
adipose	100%	4928.70	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8867.04	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	48.98	29 / 29
muscle	100%	6406.77	803 / 803	0%	0	0 / 0
spleen	100%	5178.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	57.91	45 / 45
ureter	0%	0	0 / 0	100%	43.13	1 / 1
eye	0%	0	0 / 0	99%	69.65	79 / 80
heart	97%	8345.51	836 / 861	0%	0	0 / 0
peripheral blood	63%	1096.69	584 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0019509	Biological process	L-methionine salvage from methylthioadenosine
GO_0006555	Biological process	methionine metabolic process
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0016151	Molecular function	nickel cation binding
GO_0016491	Molecular function	oxidoreductase activity
GO_0005506	Molecular function	iron ion binding
GO_0005515	Molecular function	protein binding
GO_0010309	Molecular function	acireductone dioxygenase [iron(II)-requiring] activity
GO_0010308	Molecular function	acireductone dioxygenase (Ni2+-requiring) activity

IV. Literature review

[source]

Gene name	ADI1
Protein name	Acireductone dioxygenase 1 acireductone dioxygenase (Fe(2+)-requiring) (EC 1.13.11.54) Acireductone dioxygenase (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD') (Fe-ARD) (EC 1.13.11.54) (Acireductone dioxygenase (Ni(2+)-requiring)) (ARD) (Ni-ARD) (EC 1.13.11.53) (Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1) (MTCBP-1) (Submergence-induced protein-like factor) (Sip-L)
Synonyms	MTCBP1 HMFT1638
Description	FUNCTION: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway . Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity). Also down-regulates cell migration mediated by MMP14 . Necessary for hepatitis C virus replication in an otherwise non-permissive cell line . .
Accessions	H7C382 ENST00000327435.11 [Q9BV57-1] ENST00000382093.5 [Q9BV57-2] Q9BV57 A0A0G2JQN5 ENST00000627048.1 ENST00000415131.1

ADI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review