Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 29 studies | 30% ± 16% | |
astrocyte | 23 studies | 41% ± 17% | |
macrophage | 21 studies | 27% ± 11% | |
fibroblast | 20 studies | 26% ± 11% | |
oligodendrocyte precursor cell | 16 studies | 41% ± 18% | |
oligodendrocyte | 14 studies | 36% ± 12% | |
pericyte | 12 studies | 26% ± 8% | |
smooth muscle cell | 12 studies | 21% ± 7% | |
ciliated cell | 11 studies | 31% ± 13% | |
glutamatergic neuron | 11 studies | 47% ± 23% | |
basal cell | 11 studies | 30% ± 17% | |
epithelial cell | 10 studies | 36% ± 20% | |
GABAergic neuron | 10 studies | 44% ± 21% | |
microglial cell | 10 studies | 25% ± 7% | |
monocyte | 9 studies | 26% ± 10% | |
classical monocyte | 9 studies | 23% ± 6% | |
myeloid cell | 9 studies | 24% ± 5% | |
dendritic cell | 8 studies | 25% ± 7% | |
type I pneumocyte | 8 studies | 22% ± 4% | |
club cell | 8 studies | 27% ± 10% | |
respiratory goblet cell | 8 studies | 35% ± 15% | |
adipocyte | 8 studies | 29% ± 11% | |
type II pneumocyte | 7 studies | 25% ± 6% | |
capillary endothelial cell | 7 studies | 20% ± 4% | |
amacrine cell | 7 studies | 47% ± 17% | |
retina horizontal cell | 7 studies | 70% ± 17% | |
retinal ganglion cell | 7 studies | 64% ± 28% | |
secretory cell | 6 studies | 30% ± 15% | |
conventional dendritic cell | 6 studies | 23% ± 3% | |
connective tissue cell | 6 studies | 21% ± 4% | |
neuron | 6 studies | 47% ± 13% | |
myofibroblast cell | 6 studies | 22% ± 13% | |
retinal cone cell | 6 studies | 34% ± 11% | |
Mueller cell | 6 studies | 34% ± 11% | |
goblet cell | 6 studies | 31% ± 25% | |
interneuron | 6 studies | 46% ± 27% | |
endothelial cell of lymphatic vessel | 5 studies | 20% ± 4% | |
mucus secreting cell | 5 studies | 40% ± 13% | |
plasmacytoid dendritic cell | 5 studies | 26% ± 9% | |
alveolar macrophage | 4 studies | 31% ± 13% | |
deuterosomal cell | 4 studies | 27% ± 11% | |
duct epithelial cell | 4 studies | 35% ± 28% | |
non-classical monocyte | 4 studies | 18% ± 2% | |
abnormal cell | 4 studies | 30% ± 15% | |
retinal bipolar neuron | 4 studies | 27% ± 10% | |
kidney loop of Henle epithelial cell | 4 studies | 20% ± 4% | |
retinal pigment epithelial cell | 4 studies | 29% ± 10% | |
cardiac muscle cell | 4 studies | 19% ± 2% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 26% ± 5% | |
hepatocyte | 4 studies | 49% ± 29% | |
luminal cell of prostate epithelium | 4 studies | 26% ± 9% | |
natural killer cell | 3 studies | 16% ± 1% | |
ionocyte | 3 studies | 38% ± 5% | |
glomerular endothelial cell | 3 studies | 25% ± 2% | |
GABAergic interneuron | 3 studies | 35% ± 4% | |
mononuclear phagocyte | 3 studies | 24% ± 4% | |
OFF-bipolar cell | 3 studies | 47% ± 22% | |
ON-bipolar cell | 3 studies | 47% ± 25% | |
rod bipolar cell | 3 studies | 32% ± 4% | |
endothelial cell of vascular tree | 3 studies | 21% ± 6% | |
neural progenitor cell | 3 studies | 24% ± 8% | |
ependymal cell | 3 studies | 37% ± 19% | |
gamma-delta T cell | 3 studies | 22% ± 8% | |
transit amplifying cell | 3 studies | 40% ± 25% | |
granule cell | 3 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 5842.67 | 245 / 245 | 100% | 175.58 | 502 / 502 |
breast | 100% | 3963.20 | 459 / 459 | 100% | 99.97 | 1114 / 1118 |
lung | 100% | 4628.86 | 578 / 578 | 100% | 50.56 | 1150 / 1155 |
brain | 100% | 5989.83 | 2642 / 2642 | 99% | 67.65 | 701 / 705 |
esophagus | 100% | 4215.67 | 1444 / 1445 | 99% | 52.73 | 182 / 183 |
intestine | 100% | 3538.53 | 966 / 966 | 98% | 48.38 | 517 / 527 |
skin | 100% | 4019.92 | 1805 / 1809 | 98% | 117.40 | 464 / 472 |
stomach | 100% | 5250.85 | 359 / 359 | 98% | 48.11 | 279 / 286 |
uterus | 100% | 3015.76 | 170 / 170 | 97% | 42.29 | 447 / 459 |
thymus | 100% | 3193.81 | 652 / 653 | 97% | 39.12 | 588 / 605 |
bladder | 100% | 3660.14 | 21 / 21 | 96% | 43.75 | 486 / 504 |
liver | 100% | 3317.65 | 226 / 226 | 93% | 33.93 | 376 / 406 |
ovary | 100% | 2643.59 | 180 / 180 | 91% | 23.61 | 393 / 430 |
adrenal gland | 100% | 4414.86 | 258 / 258 | 91% | 31.89 | 209 / 230 |
pancreas | 90% | 1211.73 | 294 / 328 | 99% | 39.36 | 176 / 178 |
kidney | 100% | 2612.58 | 89 / 89 | 86% | 25.02 | 778 / 901 |
adipose | 100% | 3354.39 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 3350.42 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2134.10 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 40.22 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 19.41 | 1 / 1 |
blood vessel | 100% | 4420.50 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 97% | 2246.50 | 836 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 86% | 35.53 | 69 / 80 |
peripheral blood | 77% | 1768.43 | 711 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 76% | 15.90 | 22 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035336 | Biological process | long-chain fatty-acyl-CoA metabolic process |
GO_0042998 | Biological process | positive regulation of Golgi to plasma membrane protein transport |
GO_2001247 | Biological process | positive regulation of phosphatidylcholine biosynthetic process |
GO_0034379 | Biological process | very-low-density lipoprotein particle assembly |
GO_0006631 | Biological process | fatty acid metabolic process |
GO_0030182 | Biological process | neuron differentiation |
GO_0044539 | Biological process | long-chain fatty acid import into cell |
GO_0001676 | Biological process | long-chain fatty acid metabolic process |
GO_0051047 | Biological process | positive regulation of secretion |
GO_0035338 | Biological process | long-chain fatty-acyl-CoA biosynthetic process |
GO_0005778 | Cellular component | peroxisomal membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005811 | Cellular component | lipid droplet |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005741 | Cellular component | mitochondrial outer membrane |
GO_0019904 | Molecular function | protein domain specific binding |
GO_0031956 | Molecular function | medium-chain fatty acid-CoA ligase activity |
GO_0004467 | Molecular function | long-chain fatty acid-CoA ligase activity |
GO_0090433 | Molecular function | palmitoyl-CoA ligase activity |
GO_0019901 | Molecular function | protein kinase binding |
GO_0047676 | Molecular function | arachidonate-CoA ligase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | ACSL3 |
Protein name | Acyl-CoA synthetase long chain family member 3 Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2) long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) ACSL3 protein |
Synonyms | ACS3 LACS3 FACL3 |
Description | FUNCTION: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation . Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) . Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). . |
Accessions | ENST00000680684.1 A0A7P0TB52 ENST00000407441.5 ENST00000681009.1 A0A7P0T8L6 ENST00000680475.1 F5GWH2 ENST00000392066.7 ENST00000679558.1 O95573 Q6PIM8 ENST00000680147.1 A0A7P0TBB1 ENST00000679541.1 ENST00000681697.1 H7BYZ7 ENST00000680736.1 ENST00000540115.1 A0A7P0T905 ENST00000680251.1 A0A7P0TBL9 A0A7P0TA76 ENST00000681906.1 ENST00000357430.8 ENST00000681383.1 ENST00000681292.1 ENST00000679545.1 C9JC11 ENST00000679514.1 ENST00000413316.1 ENST00000680525.1 ENST00000680420.1 ENST00000680921.1 ENST00000680395.1 |