ACSL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035336Biological processlong-chain fatty-acyl-CoA metabolic process
GO_0042998Biological processpositive regulation of Golgi to plasma membrane protein transport
GO_2001247Biological processpositive regulation of phosphatidylcholine biosynthetic process
GO_0034379Biological processvery-low-density lipoprotein particle assembly
GO_0006631Biological processfatty acid metabolic process
GO_0030182Biological processneuron differentiation
GO_0044539Biological processlong-chain fatty acid import into cell
GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0051047Biological processpositive regulation of secretion
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0005778Cellular componentperoxisomal membrane
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005783Cellular componentendoplasmic reticulum
GO_0005741Cellular componentmitochondrial outer membrane
GO_0019904Molecular functionprotein domain specific binding
GO_0031956Molecular functionmedium-chain fatty acid-CoA ligase activity
GO_0004467Molecular functionlong-chain fatty acid-CoA ligase activity
GO_0090433Molecular functionpalmitoyl-CoA ligase activity
GO_0019901Molecular functionprotein kinase binding
GO_0047676Molecular functionarachidonate-CoA ligase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameACSL3
Protein nameAcyl-CoA synthetase long chain family member 3
Fatty acid CoA ligase Acsl3 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 3) (LACS 3) (Long-chain-fatty-acid--CoA ligase 3) (EC 6.2.1.3) (Medium-chain acyl-CoA ligase Acsl3) (EC 6.2.1.2)
long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
ACSL3 protein
SynonymsACS3
LACS3
FACL3
DescriptionFUNCTION: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation . Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) . Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). .

AccessionsENST00000680684.1
A0A7P0TB52
ENST00000407441.5
ENST00000681009.1
A0A7P0T8L6
ENST00000680475.1
F5GWH2
ENST00000392066.7
ENST00000679558.1
O95573
Q6PIM8
ENST00000680147.1
A0A7P0TBB1
ENST00000679541.1
ENST00000681697.1
H7BYZ7
ENST00000680736.1
ENST00000540115.1
A0A7P0T905
ENST00000680251.1
A0A7P0TBL9
A0A7P0TA76
ENST00000681906.1
ENST00000357430.8
ENST00000681383.1
ENST00000681292.1
ENST00000679545.1
C9JC11
ENST00000679514.1
ENST00000413316.1
ENST00000680525.1
ENST00000680420.1
ENST00000680921.1
ENST00000680395.1