ABCB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	19 studies	49% ± 22%	Explore
glutamatergic neuron	6 studies	38% ± 17%	Explore
natural killer cell	5 studies	20% ± 4%	Explore
enterocyte	5 studies	24% ± 5%	Explore
GABAergic neuron	5 studies	31% ± 16%	Explore
mucosal invariant T cell	5 studies	19% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	25% ± 5%	Explore
endothelial cell of vascular tree	5 studies	39% ± 18%	Explore
vein endothelial cell	4 studies	35% ± 25%	Explore
renal principal cell	4 studies	26% ± 6%	Explore
pancreatic A cell	3 studies	22% ± 5%	Explore
gamma-delta T cell	3 studies	25% ± 4%	Explore
interneuron	3 studies	42% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	3 studies	40% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	26922.88	258 / 258	97%	57.44	224 / 230
brain	99%	1795.56	2624 / 2642	97%	16.07	684 / 705
liver	100%	1649.60	226 / 226	86%	27.64	348 / 406
kidney	100%	1711.75	89 / 89	83%	42.90	751 / 901
prostate	99%	1020.65	242 / 245	75%	5.71	374 / 502
intestine	95%	2106.41	919 / 966	72%	17.22	379 / 527
thymus	97%	739.63	631 / 653	41%	2.25	251 / 605
stomach	64%	285.43	231 / 359	65%	13.08	186 / 286
breast	96%	1330.47	441 / 459	30%	1.90	340 / 1118
esophagus	91%	453.38	1314 / 1445	28%	1.70	51 / 183
uterus	99%	1839.78	168 / 170	15%	1.06	67 / 459
bladder	76%	516.10	16 / 21	26%	4.66	132 / 504
pancreas	32%	116.52	106 / 328	69%	11.23	122 / 178
spleen	100%	699.10	241 / 241	0%	0	0 / 0
lung	76%	439.67	438 / 578	16%	1.13	181 / 1155
adipose	88%	624.73	1065 / 1204	0%	0	0 / 0
ovary	87%	496.16	156 / 180	1%	0.13	6 / 430
skin	24%	78.45	439 / 1809	22%	1.53	105 / 472
heart	46%	202.53	392 / 861	0%	0	0 / 0
peripheral blood	39%	186.64	362 / 929	0%	0	0 / 0
blood vessel	32%	138.30	424 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	31%	6.85	9 / 29
tonsil	0%	0	0 / 0	16%	0.66	7 / 45
muscle	1%	1.61	5 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006805	Biological process	xenobiotic metabolic process
GO_0055085	Biological process	transmembrane transport
GO_0150104	Biological process	transport across blood-brain barrier
GO_0070633	Biological process	transepithelial transport
GO_1990962	Biological process	xenobiotic transport across blood-brain barrier
GO_0047484	Biological process	regulation of response to osmotic stress
GO_1990961	Biological process	xenobiotic detoxification by transmembrane export across the plasma membrane
GO_0140115	Biological process	export across plasma membrane
GO_1905039	Biological process	carboxylic acid transmembrane transport
GO_1901529	Biological process	positive regulation of anion channel activity
GO_0046865	Biological process	terpenoid transport
GO_0045332	Biological process	phospholipid translocation
GO_0099040	Biological process	ceramide translocation
GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_0009410	Biological process	response to xenobiotic stimulus
GO_2001225	Biological process	regulation of chloride transport
GO_0072089	Biological process	stem cell proliferation
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0098591	Cellular component	external side of apical plasma membrane
GO_0009986	Cellular component	cell surface
GO_0005737	Cellular component	cytoplasm
GO_0046943	Molecular function	carboxylic acid transmembrane transporter activity
GO_0090554	Molecular function	phosphatidylcholine floppase activity
GO_0015562	Molecular function	efflux transmembrane transporter activity
GO_0008559	Molecular function	ABC-type xenobiotic transporter activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0099038	Molecular function	ceramide floppase activity
GO_0042910	Molecular function	xenobiotic transmembrane transporter activity
GO_0090555	Molecular function	phosphatidylethanolamine flippase activity
GO_0140328	Molecular function	floppase activity
GO_0005524	Molecular function	ATP binding
GO_0042626	Molecular function	ATPase-coupled transmembrane transporter activity
GO_0005515	Molecular function	protein binding
GO_0022857	Molecular function	transmembrane transporter activity
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	ABCB1
Protein name	ATP-binding cassette, sub-family B (MDR/TAP), member 1 Multidrug resistance protein 1 ATP binding cassette subfamily B member 1 ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243) p-glycoprotein 1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (Multidrug resistance protein 1) Uncharacterized protein ABCB1
Synonyms	tcag7.316 hCG_20818 PGY1 MDR1
Description	FUNCTION: Translocates drugs and phospholipids across the membrane . Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins . Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells . .
Accessions	ENST00000416177.1 F4ZUQ5 F4ZUV4 B5U2G4 F4ZUV0 F4ZV79 F4ZUT2 ENST00000543898.5 [P08183-2] Q6TBL4 F4ZUX9 A1L471 A8E2S6 ENST00000265724.8 [P08183-1] ENST00000622132.5 [P08183-1] E7EWT8 F4ZUY5 P08183 A4D1D2

ABCB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review