AATF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007155Biological processcell adhesion
GO_0042274Biological processribosomal small subunit biogenesis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007346Biological processregulation of mitotic cell cycle
GO_0042985Biological processnegative regulation of amyloid precursor protein biosynthetic process
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_0040016Biological processembryonic cleavage
GO_0005730Cellular componentnucleolus
GO_0032040Cellular componentsmall-subunit processome
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0043522Molecular functionleucine zipper domain binding
GO_0019901Molecular functionprotein kinase binding
GO_0048156Molecular functiontau protein binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAATF
Protein nameProtein AATF
Apoptosis antagonizing transcription factor (Protein AATF)
Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1)
Apoptosis antagonizing transcription factor
SynonymsHSPC277
DED
CHE1
DescriptionFUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. .

AccessionsA0A087WTH8
ENST00000620004.2
A0A7P0T868
A0A7P0Z434
ENST00000610798.4
A0A7P0TBI0
ENST00000613840.1
ENST00000680330.1
ENST00000632435.1
ENST00000632039.1
A0A7P0Z4N2
Q9NY61
ENST00000680340.1
ENST00000633401.1
A0A7P0TBG4
A0A7P0TAR0
ENST00000680782.1
A0A0J9YWE9
ENST00000679881.1
ENST00000619387.5
ENST00000679997.1
A0A087WW41
A0A7P0Z4P2
A0A087WWS8
ENST00000616434.2
ENST00000680579.1
ENST00000681062.1
ENST00000680356.1