ZNF423 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061512Biological processprotein localization to cilium
GO_0007399Biological processnervous system development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0007219Biological processNotch signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0006355Biological processregulation of DNA-templated transcription
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF423
Protein nameZinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein)
Zinc finger protein 423
SynonymsKIAA0760
NPHP14
OAZ
DescriptionFUNCTION: Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. .

AccessionsENST00000568094.2
ENST00000562520.1 [Q2M1K9-2]
Q2M1K9
F5H7S1
ENST00000567169.5
ENST00000535559.5
ENST00000563137.7
A0A7P0Q1F0
A0A087WV99
ENST00000561648.5 [Q2M1K9-1]
ENST00000562871.5 [Q2M1K9-2]