Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 31% ± 11% | |
astrocyte | 16 studies | 40% ± 19% | |
oligodendrocyte precursor cell | 13 studies | 49% ± 21% | |
GABAergic neuron | 11 studies | 44% ± 25% | |
glutamatergic neuron | 11 studies | 53% ± 26% | |
B cell | 11 studies | 21% ± 4% | |
microglial cell | 11 studies | 31% ± 12% | |
oligodendrocyte | 11 studies | 33% ± 12% | |
neuron | 7 studies | 35% ± 14% | |
epithelial cell | 7 studies | 29% ± 11% | |
interneuron | 6 studies | 53% ± 28% | |
macrophage | 6 studies | 31% ± 8% | |
adipocyte | 6 studies | 27% ± 6% | |
fibroblast | 6 studies | 24% ± 6% | |
Mueller cell | 6 studies | 31% ± 12% | |
type I pneumocyte | 6 studies | 28% ± 11% | |
type II pneumocyte | 6 studies | 37% ± 7% | |
club cell | 5 studies | 31% ± 13% | |
smooth muscle cell | 5 studies | 21% ± 4% | |
granule cell | 4 studies | 35% ± 7% | |
retinal ganglion cell | 4 studies | 30% ± 13% | |
amacrine cell | 4 studies | 28% ± 9% | |
endothelial cell of lymphatic vessel | 4 studies | 29% ± 2% | |
mast cell | 4 studies | 18% ± 3% | |
memory B cell | 3 studies | 16% ± 2% | |
naive B cell | 3 studies | 18% ± 0% | |
GABAergic interneuron | 3 studies | 46% ± 5% | |
retinal bipolar neuron | 3 studies | 19% ± 3% | |
cardiac muscle cell | 3 studies | 17% ± 1% | |
ciliated cell | 3 studies | 23% ± 4% | |
OFF-bipolar cell | 3 studies | 24% ± 12% | |
ON-bipolar cell | 3 studies | 22% ± 8% | |
glycinergic amacrine cell | 3 studies | 30% ± 14% | |
ependymal cell | 3 studies | 41% ± 21% | |
basal cell | 3 studies | 31% ± 10% | |
pericyte | 3 studies | 23% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 2093.96 | 245 / 245 | 100% | 11.35 | 500 / 502 |
brain | 100% | 2483.21 | 2635 / 2642 | 100% | 13.71 | 704 / 705 |
breast | 100% | 2320.56 | 459 / 459 | 99% | 11.97 | 1107 / 1118 |
thymus | 100% | 2579.78 | 653 / 653 | 99% | 10.37 | 599 / 605 |
esophagus | 100% | 2437.74 | 1444 / 1445 | 99% | 12.32 | 181 / 183 |
ovary | 100% | 2388.52 | 180 / 180 | 99% | 6.91 | 425 / 430 |
lung | 100% | 2602.47 | 577 / 578 | 98% | 12.75 | 1135 / 1155 |
bladder | 100% | 1995.19 | 21 / 21 | 96% | 8.31 | 486 / 504 |
kidney | 100% | 1666.57 | 89 / 89 | 96% | 7.63 | 866 / 901 |
pancreas | 100% | 1252.57 | 327 / 328 | 96% | 6.78 | 171 / 178 |
uterus | 100% | 2667.74 | 170 / 170 | 96% | 8.72 | 439 / 459 |
intestine | 100% | 2296.37 | 966 / 966 | 96% | 7.40 | 504 / 527 |
stomach | 100% | 1477.40 | 359 / 359 | 94% | 7.99 | 269 / 286 |
adrenal gland | 100% | 2009.58 | 258 / 258 | 93% | 9.75 | 215 / 230 |
skin | 100% | 1851.34 | 1803 / 1809 | 78% | 4.27 | 368 / 472 |
liver | 89% | 627.14 | 201 / 226 | 45% | 1.96 | 181 / 406 |
blood vessel | 100% | 2417.90 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 2271.20 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.71 | 1 / 1 |
adipose | 100% | 1746.02 | 1202 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 1233.94 | 801 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 7.82 | 44 / 45 |
lymph node | 0% | 0 | 0 / 0 | 97% | 11.57 | 28 / 29 |
heart | 96% | 1422.67 | 824 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 41% | 1.75 | 33 / 80 |
peripheral blood | 25% | 825.25 | 230 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1904997 | Biological process | regulation of leukocyte adhesion to arterial endothelial cell |
GO_0003056 | Biological process | regulation of vascular associated smooth muscle contraction |
GO_0018345 | Biological process | protein palmitoylation |
GO_0046209 | Biological process | nitric oxide metabolic process |
GO_0048733 | Biological process | sebaceous gland development |
GO_0018230 | Biological process | peptidyl-L-cysteine S-palmitoylation |
GO_1903140 | Biological process | regulation of establishment of endothelial barrier |
GO_0006612 | Biological process | protein targeting to membrane |
GO_0071875 | Biological process | adrenergic receptor signaling pathway |
GO_0001942 | Biological process | hair follicle development |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005886 | Cellular component | plasma membrane |
GO_0016409 | Molecular function | palmitoyltransferase activity |
GO_0019706 | Molecular function | protein-cysteine S-palmitoyltransferase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | ZDHHC21 |
Protein name | Palmitoyltransferase ZDHHC21 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 21) (DHHC-21) (Zinc finger DHHC domain-containing protein 21) |
Synonyms | |
Description | FUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates . Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane . This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor . Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity). . |
Accessions | ENST00000380916.9 Q8IVQ6 |