WRN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0090656Biological processt-circle formation
GO_1902570Biological processprotein localization to nucleolus
GO_0006268Biological processDNA unwinding involved in DNA replication
GO_0008340Biological processdetermination of adult lifespan
GO_0006302Biological processdouble-strand break repair
GO_0010225Biological processresponse to UV-C
GO_0006974Biological processDNA damage response
GO_0090399Biological processreplicative senescence
GO_0009267Biological processcellular response to starvation
GO_0006260Biological processDNA replication
GO_0040009Biological processregulation of growth rate
GO_0098530Biological processpositive regulation of strand invasion
GO_0071480Biological processcellular response to gamma radiation
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0031297Biological processreplication fork processing
GO_0044806Biological processG-quadruplex DNA unwinding
GO_0006259Biological processDNA metabolic process
GO_0032201Biological processtelomere maintenance via semi-conservative replication
GO_0000723Biological processtelomere maintenance
GO_0000731Biological processDNA synthesis involved in DNA repair
GO_0061820Biological processtelomeric D-loop disassembly
GO_0090398Biological processcellular senescence
GO_0006284Biological processbase-excision repair
GO_0006979Biological processresponse to oxidative stress
GO_0051345Biological processpositive regulation of hydrolase activity
GO_0005730Cellular componentnucleolus
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005694Cellular componentchromosome
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0061821Molecular functiontelomeric D-loop binding
GO_0004527Molecular functionexonuclease activity
GO_1905773Molecular function8-hydroxy-2'-deoxyguanosine DNA binding
GO_0003682Molecular functionchromatin binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0009378Molecular functionfour-way junction helicase activity
GO_0061849Molecular functiontelomeric G-quadruplex DNA binding
GO_0032405Molecular functionMutLalpha complex binding
GO_0000405Molecular functionbubble DNA binding
GO_0000287Molecular functionmagnesium ion binding
GO_0008408Molecular function3'-5' exonuclease activity
GO_0030145Molecular functionmanganese ion binding
GO_0000400Molecular functionfour-way junction DNA binding
GO_0051880Molecular functionG-quadruplex DNA binding
GO_0070337Molecular function3'-flap-structured DNA binding
GO_0003678Molecular functionDNA helicase activity
GO_0005524Molecular functionATP binding
GO_0061749Molecular functionforked DNA-dependent helicase activity
GO_0016853Molecular functionisomerase activity
GO_0000403Molecular functionY-form DNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0043138Molecular function3'-5' DNA helicase activity

IV. Literature review

[source]
Gene nameWRN
Protein nameBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]
WRN RecQ like helicase
SynonymsRECQL2
RECQ3
DescriptionFUNCTION: Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates . Also has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang . Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA . Helicase activity is most efficient with (d)ATP, but (d)CTP will substitute with reduced efficiency; strand displacement is enhanced by single-strand binding-protein (heterotrimeric replication protein A complex, RPA1, RPA2, RPA3) . Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation . Depletion leads to chromosomal breaks and genome instability . .

AccessionsENST00000298139.7
A0A494C0Y6
A0A494C0M3
Q14191
ENST00000650667.1
ENST00000651642.1