WIPI2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098792Biological processxenophagy
GO_0030242Biological processautophagy of peroxisome
GO_0000045Biological processautophagosome assembly
GO_0006497Biological processprotein lipidation
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0009267Biological processcellular response to starvation
GO_0000422Biological processautophagy of mitochondrion
GO_0097352Biological processautophagosome maturation
GO_0061723Biological processglycophagy
GO_0044804Biological processnucleophagy
GO_0016020Cellular componentmembrane
GO_0034045Cellular componentphagophore assembly site membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0019898Cellular componentextrinsic component of membrane
GO_0005829Cellular componentcytosol
GO_0000407Cellular componentphagophore assembly site
GO_0005776Cellular componentautophagosome
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWIPI2
Protein nameAlternative protein WIPI2
WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2)
SynonymsCGI-50
DescriptionFUNCTION: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation . Involved in an early step of the formation of preautophagosomal structures . Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases . Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P . Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane . .; FUNCTION: [Isoform 4]: Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. .

AccessionsENST00000404704.7 [Q9Y4P8-6]
L8E8Q1
ENST00000401525.7 [Q9Y4P8-4]
Q9Y4P8
ENST00000288828.9 [Q9Y4P8-1]
ENST00000382384.6 [Q9Y4P8-2]
ENST00000484262.1 [Q9Y4P8-3]