WDFY3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035973Biological processaggrephagy
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0000421Cellular componentautophagosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_0016234Cellular componentinclusion body
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0034274Cellular componentAtg12-Atg5-Atg16 complex
GO_0030424Cellular componentaxon
GO_0031965Cellular componentnuclear membrane
GO_0005545Molecular function1-phosphatidylinositol binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWDFY3
Protein nameWDFY3 protein
WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)
WD repeat and FYVE domain containing 3
SynonymshCG_15053
KIAA0993
DescriptionFUNCTION: Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 . Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus . Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development . May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation . In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) . .

AccessionsH0Y9T6
ENST00000509172.1
D6RJE4
H0YAD8
Q8IZQ1
ENST00000502713.1
A7E1Z6
ENST00000514071.1
ENST00000514711.2
A7E293
A0A1D5RMR8
ENST00000295888.9 [Q8IZQ1-1]