Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 23 studies | 45% ± 17% | |
astrocyte | 19 studies | 54% ± 20% | |
macrophage | 18 studies | 44% ± 24% | |
oligodendrocyte | 15 studies | 57% ± 16% | |
microglial cell | 15 studies | 59% ± 15% | |
oligodendrocyte precursor cell | 14 studies | 53% ± 19% | |
glutamatergic neuron | 12 studies | 61% ± 22% | |
pericyte | 12 studies | 43% ± 22% | |
fibroblast | 12 studies | 42% ± 15% | |
GABAergic neuron | 11 studies | 59% ± 22% | |
smooth muscle cell | 11 studies | 38% ± 15% | |
myeloid cell | 10 studies | 37% ± 18% | |
adipocyte | 9 studies | 34% ± 13% | |
epithelial cell | 8 studies | 40% ± 21% | |
neuron | 7 studies | 52% ± 23% | |
basal cell | 7 studies | 36% ± 26% | |
interneuron | 6 studies | 69% ± 17% | |
dendritic cell | 6 studies | 27% ± 8% | |
ciliated cell | 6 studies | 31% ± 13% | |
endothelial cell of lymphatic vessel | 6 studies | 44% ± 18% | |
monocyte | 5 studies | 43% ± 9% | |
type I pneumocyte | 5 studies | 33% ± 11% | |
type II pneumocyte | 5 studies | 38% ± 10% | |
classical monocyte | 4 studies | 22% ± 3% | |
granule cell | 4 studies | 58% ± 6% | |
retinal ganglion cell | 4 studies | 51% ± 25% | |
cardiac muscle cell | 4 studies | 32% ± 5% | |
mesothelial cell | 4 studies | 36% ± 15% | |
Mueller cell | 4 studies | 54% ± 20% | |
amacrine cell | 4 studies | 54% ± 18% | |
retina horizontal cell | 4 studies | 47% ± 21% | |
retinal cone cell | 4 studies | 50% ± 20% | |
retinal rod cell | 4 studies | 47% ± 11% | |
club cell | 4 studies | 40% ± 12% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 55% ± 0% | |
GABAergic interneuron | 3 studies | 63% ± 2% | |
glial cell | 3 studies | 40% ± 11% | |
progenitor cell | 3 studies | 52% ± 12% | |
endothelial cell of artery | 3 studies | 24% ± 6% | |
mononuclear phagocyte | 3 studies | 34% ± 16% | |
vein endothelial cell | 3 studies | 42% ± 21% | |
GABAergic amacrine cell | 3 studies | 55% ± 19% | |
glycinergic amacrine cell | 3 studies | 52% ± 16% | |
endothelial cell of vascular tree | 3 studies | 45% ± 25% | |
hepatocyte | 3 studies | 47% ± 19% | |
retinal pigment epithelial cell | 3 studies | 46% ± 26% | |
ependymal cell | 3 studies | 70% ± 12% | |
alveolar macrophage | 3 studies | 49% ± 14% | |
capillary endothelial cell | 3 studies | 32% ± 12% | |
myofibroblast cell | 3 studies | 34% ± 18% | |
respiratory goblet cell | 3 studies | 41% ± 16% | |
goblet cell | 3 studies | 42% ± 32% | |
mucus secreting cell | 3 studies | 33% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 6109.32 | 2642 / 2642 | 100% | 27.28 | 703 / 705 |
esophagus | 100% | 3866.45 | 1445 / 1445 | 99% | 12.89 | 182 / 183 |
kidney | 100% | 4305.33 | 89 / 89 | 99% | 19.68 | 894 / 901 |
prostate | 100% | 3869.87 | 245 / 245 | 99% | 14.00 | 496 / 502 |
breast | 100% | 4418.10 | 459 / 459 | 97% | 15.53 | 1088 / 1118 |
lung | 100% | 4903.44 | 578 / 578 | 97% | 9.94 | 1118 / 1155 |
adrenal gland | 100% | 4550.26 | 258 / 258 | 96% | 11.36 | 220 / 230 |
pancreas | 97% | 1965.63 | 318 / 328 | 97% | 10.12 | 173 / 178 |
bladder | 100% | 3954.48 | 21 / 21 | 93% | 8.46 | 470 / 504 |
thymus | 100% | 4906.44 | 653 / 653 | 93% | 11.17 | 563 / 605 |
ovary | 100% | 4862.13 | 180 / 180 | 93% | 6.55 | 400 / 430 |
skin | 100% | 5391.95 | 1809 / 1809 | 90% | 8.61 | 425 / 472 |
stomach | 100% | 2836.77 | 359 / 359 | 90% | 7.34 | 257 / 286 |
uterus | 100% | 4765.02 | 170 / 170 | 89% | 7.38 | 410 / 459 |
intestine | 100% | 3407.49 | 966 / 966 | 89% | 6.34 | 467 / 527 |
liver | 89% | 1240.12 | 202 / 226 | 38% | 2.71 | 155 / 406 |
adipose | 100% | 5056.08 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5552.45 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 3748.10 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.35 | 1 / 1 |
muscle | 99% | 2213.43 | 795 / 803 | 0% | 0 | 0 / 0 |
heart | 95% | 2171.51 | 814 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 87% | 7.08 | 39 / 45 |
peripheral blood | 77% | 4084.95 | 715 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 66% | 4.32 | 53 / 80 |
lymph node | 0% | 0 | 0 / 0 | 31% | 1.54 | 9 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035973 | Biological process | aggrephagy |
GO_0005730 | Cellular component | nucleolus |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0043204 | Cellular component | perikaryon |
GO_0000421 | Cellular component | autophagosome membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005635 | Cellular component | nuclear envelope |
GO_0016234 | Cellular component | inclusion body |
GO_0005829 | Cellular component | cytosol |
GO_0016605 | Cellular component | PML body |
GO_0005776 | Cellular component | autophagosome |
GO_0005737 | Cellular component | cytoplasm |
GO_0034274 | Cellular component | Atg12-Atg5-Atg16 complex |
GO_0030424 | Cellular component | axon |
GO_0031965 | Cellular component | nuclear membrane |
GO_0005545 | Molecular function | 1-phosphatidylinositol binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | WDFY3 |
Protein name | WDFY3 protein WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) WD repeat and FYVE domain containing 3 |
Synonyms | hCG_15053 KIAA0993 |
Description | FUNCTION: Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 . Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus . Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development . May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation . In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) . . |
Accessions | H0Y9T6 ENST00000509172.1 D6RJE4 H0YAD8 Q8IZQ1 ENST00000502713.1 A7E1Z6 ENST00000514071.1 ENST00000514711.2 A7E293 A0A1D5RMR8 ENST00000295888.9 [Q8IZQ1-1] |