WASL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000402Biological processnegative regulation of lymphocyte migration
GO_0009617Biological processresponse to bacterium
GO_0032880Biological processregulation of protein localization
GO_0030041Biological processactin filament polymerization
GO_1903526Biological processnegative regulation of membrane tubulation
GO_0051301Biological processcell division
GO_0030050Biological processvesicle transport along actin filament
GO_0008154Biological processactin polymerization or depolymerization
GO_0065003Biological processprotein-containing complex assembly
GO_0051491Biological processpositive regulation of filopodium assembly
GO_0051653Biological processspindle localization
GO_0016050Biological processvesicle organization
GO_0006900Biological processvesicle budding from membrane
GO_2000370Biological processpositive regulation of clathrin-dependent endocytosis
GO_0031503Biological processprotein-containing complex localization
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0099175Biological processregulation of postsynapse organization
GO_0060997Biological processdendritic spine morphogenesis
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030478Cellular componentactin cap
GO_0030666Cellular componentendocytic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0003779Molecular functionactin binding
GO_0030695Molecular functionGTPase regulator activity
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWASL
Protein nameActin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)
Wiskott-Aldrich syndrome-like
Synonymstcag7.28
DescriptionFUNCTION: Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex . Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization . Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia . In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization . Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity). Plays a role in dendrite spine morphogenesis (By similarity). Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear . .

AccessionsO00401
ENST00000223023.5
A4D0Y1