VPS8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006623Biological processprotein targeting to vacuole
GO_0035542Biological processregulation of SNARE complex assembly
GO_0034058Biological processendosomal vesicle fusion
GO_0033263Cellular componentCORVET complex
GO_0030897Cellular componentHOPS complex
GO_0005770Cellular componentlate endosome
GO_0005769Cellular componentearly endosome
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameVPS8
Protein nameVPS8 subunit of CORVET complex
Vacuolar protein sorting-associated protein 8 homolog
SynonymsKIAA0804
DescriptionFUNCTION: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations . Functions predominantly in APPL1-containing endosomes . .

AccessionsENST00000422105.5
ENST00000625842.3 [Q8N3P4-1]
C9JKL0
H7C058
C9JPI1
ENST00000436792.6 [Q8N3P4-3]
C9JG07
ENST00000421069.5
H7C322
C9JJN9
ENST00000426319.1
ENST00000424463.4
C9JP71
H7C1G7
ENST00000458721.5
C9JIA0
ENST00000453056.5
ENST00000446204.6 [Q8N3P4-2]
Q8N3P4
ENST00000628962.1
F8WB24
ENST00000424721.5
ENST00000287546.8
ENST00000441141.5
ENST00000452140.5
H7C490
ENST00000445089.5