VPS53 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0090119Biological processvesicle-mediated cholesterol transport
GO_0006622Biological processprotein targeting to lysosome
GO_0032456Biological processendocytic recycling
GO_0007041Biological processlysosomal transport
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_1990745Cellular componentEARP complex
GO_0000938Cellular componentGARP complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVPS53
Protein nameVPS53 subunit of GARP complex
Alternative protein VPS53
Vacuolar protein sorting-associated protein 53 homolog
VPS53 protein
SynonymsPP13624
DescriptionFUNCTION: Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD . Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane . .

AccessionsENST00000573028.5
ENST00000681295.1
A0A7P0T8S5
ENST00000681510.1
A0A7P0T8V2
ENST00000680465.1 [Q5VIR6-4]
ENST00000681317.1
A0A7P0T9Z7
ENST00000572334.7
A0A7P0TAK4
A0A7P0T8A5
E7EVT8
ENST00000680704.1
L8E9S5
ENST00000681902.1
ENST00000680128.1
A0A7P0TA41
A0A7P0T9X9
ENST00000572259.2
A0A7P0T8I9
ENST00000389040.9
A0A7P0T8K1
A0A7P0TB16
ENST00000570650.2
ENST00000681661.1
ENST00000576149.5
ENST00000679865.1
A0A7P0TB80
ENST00000680069.1 [Q5VIR6-3]
ENST00000571805.6 [Q5VIR6-1]
ENST00000681423.1
A0A7P0T8A9
ENST00000681120.1
ENST00000639801.2 [Q5VIR6-4]
A0A7P0T8P7
ENST00000571456.2
ENST00000681160.1
ENST00000679961.1
A0A7P0TA82
ENST00000681946.1
Q8NCR1
ENST00000639896.1 [Q5VIR6-1]
ENST00000679817.1
A0A7P0T8D0
A0A7P0Z4Q7
ENST00000681943.1
A0A7P0T7U9
A0A7P0T9V8
ENST00000680114.1
ENST00000679680.1
ENST00000681096.1
I3L1W6
L8EC79
ENST00000681133.1
A0A7P0Z4K0
A0A7P0T8V1
ENST00000681154.1
F6VX93
ENST00000679959.1
ENST00000680641.1
ENST00000638350.1 [Q5VIR6-2]
A0A7P0TAF8
ENST00000680970.1
A0A7P0T9B2
ENST00000680241.1
A0A7P0Z4M8
A0A7P0T804
A0A7P0T8V9
ENST00000401468.7
ENST00000575100.2
ENST00000679361.1
ENST00000291074.10 [Q5VIR6-2]
A0A7P0Z400
A0A7P0TA79
ENST00000576019.6
A0A7P0T874
ENST00000437048.7 [Q5VIR6-4]
ENST00000680872.1
A0A7P0TAE0
A0A7P0TBJ8
ENST00000574029.6
ENST00000681103.1
A0A7P0T805
A0A7P0TBK3
ENST00000681830.1
A0A7P0Z461
I3L4P9
A0A7P0T9B6
A0A7P0TA53
ENST00000681478.1
I3L184
ENST00000681229.1
Q5VIR6
ENST00000681917.1
ENST00000681858.1
ENST00000575207.6
ENST00000681050.1
A0A7P0TBG3
I3L0S6