Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 17 studies | 31% ± 15% | |
| astrocyte | 12 studies | 35% ± 19% | |
| macrophage | 10 studies | 34% ± 15% | |
| glutamatergic neuron | 9 studies | 46% ± 21% | |
| adipocyte | 9 studies | 26% ± 6% | |
| fibroblast | 9 studies | 25% ± 9% | |
| oligodendrocyte | 8 studies | 35% ± 13% | |
| ciliated cell | 8 studies | 23% ± 8% | |
| neuron | 7 studies | 38% ± 15% | |
| GABAergic neuron | 7 studies | 44% ± 20% | |
| epithelial cell | 7 studies | 35% ± 16% | |
| microglial cell | 7 studies | 33% ± 13% | |
| myeloid cell | 7 studies | 28% ± 8% | |
| mast cell | 7 studies | 24% ± 5% | |
| oligodendrocyte precursor cell | 6 studies | 37% ± 15% | |
| dendritic cell | 6 studies | 21% ± 3% | |
| smooth muscle cell | 6 studies | 19% ± 2% | |
| amacrine cell | 5 studies | 25% ± 4% | |
| interneuron | 5 studies | 57% ± 22% | |
| endothelial cell of lymphatic vessel | 5 studies | 24% ± 8% | |
| monocyte | 5 studies | 30% ± 9% | |
| type I pneumocyte | 5 studies | 26% ± 7% | |
| type II pneumocyte | 5 studies | 25% ± 5% | |
| basal cell | 5 studies | 30% ± 18% | |
| non-classical monocyte | 4 studies | 25% ± 9% | |
| granule cell | 4 studies | 37% ± 7% | |
| retinal ganglion cell | 4 studies | 27% ± 7% | |
| retina horizontal cell | 4 studies | 20% ± 3% | |
| club cell | 4 studies | 26% ± 7% | |
| pericyte | 4 studies | 23% ± 8% | |
| goblet cell | 4 studies | 37% ± 18% | |
| B cell | 3 studies | 23% ± 3% | |
| plasma cell | 3 studies | 31% ± 7% | |
| retinal bipolar neuron | 3 studies | 19% ± 3% | |
| retinal cone cell | 3 studies | 19% ± 4% | |
| cardiac muscle cell | 3 studies | 19% ± 2% | |
| mononuclear phagocyte | 3 studies | 22% ± 6% | |
| glycinergic amacrine cell | 3 studies | 22% ± 3% | |
| retinal rod cell | 3 studies | 24% ± 3% | |
| T cell | 3 studies | 21% ± 0% | |
| alveolar macrophage | 3 studies | 42% ± 9% | |
| lymphocyte | 3 studies | 30% ± 6% | |
| mucus secreting cell | 3 studies | 24% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 2836.39 | 245 / 245 | 100% | 8.32 | 502 / 502 |
| skin | 100% | 3345.01 | 1808 / 1809 | 100% | 11.57 | 472 / 472 |
| esophagus | 100% | 2605.12 | 1444 / 1445 | 100% | 10.00 | 183 / 183 |
| thymus | 100% | 3739.83 | 653 / 653 | 100% | 9.19 | 604 / 605 |
| brain | 100% | 5077.90 | 2641 / 2642 | 100% | 10.55 | 704 / 705 |
| breast | 100% | 2286.52 | 459 / 459 | 100% | 7.63 | 1114 / 1118 |
| intestine | 100% | 2376.81 | 966 / 966 | 100% | 7.19 | 525 / 527 |
| bladder | 100% | 2373.81 | 21 / 21 | 99% | 6.50 | 501 / 504 |
| stomach | 100% | 2278.74 | 359 / 359 | 99% | 7.61 | 284 / 286 |
| uterus | 100% | 2640.77 | 170 / 170 | 99% | 6.46 | 455 / 459 |
| lung | 100% | 3041.22 | 578 / 578 | 99% | 7.45 | 1142 / 1155 |
| kidney | 100% | 2173.93 | 89 / 89 | 98% | 6.37 | 886 / 901 |
| adrenal gland | 100% | 2580.33 | 258 / 258 | 97% | 6.52 | 224 / 230 |
| pancreas | 100% | 1617.38 | 327 / 328 | 97% | 5.72 | 173 / 178 |
| ovary | 100% | 2458.73 | 180 / 180 | 94% | 5.40 | 406 / 430 |
| liver | 100% | 1484.97 | 226 / 226 | 75% | 2.90 | 306 / 406 |
| adipose | 100% | 2240.90 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 19.71 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 7.11 | 29 / 29 |
| muscle | 100% | 2071.69 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3060.69 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 7.94 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.17 | 1 / 1 |
| blood vessel | 100% | 2002.45 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 1613.82 | 846 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 1931.89 | 903 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042147 | Biological process | retrograde transport, endosome to Golgi |
| GO_0090119 | Biological process | vesicle-mediated cholesterol transport |
| GO_0006622 | Biological process | protein targeting to lysosome |
| GO_0032456 | Biological process | endocytic recycling |
| GO_0007041 | Biological process | lysosomal transport |
| GO_0032588 | Cellular component | trans-Golgi network membrane |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_1990745 | Cellular component | EARP complex |
| GO_0000938 | Cellular component | GARP complex |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005515 | Molecular function | protein binding |
| Gene name | VPS53 |
| Protein name | VPS53 subunit of GARP complex Alternative protein VPS53 Vacuolar protein sorting-associated protein 53 homolog VPS53 protein |
| Synonyms | PP13624 |
| Description | FUNCTION: Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD . Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane . . |
| Accessions | ENST00000573028.5 ENST00000681295.1 A0A7P0T8S5 ENST00000681510.1 A0A7P0T8V2 ENST00000680465.1 [Q5VIR6-4] ENST00000681317.1 A0A7P0T9Z7 ENST00000572334.7 A0A7P0TAK4 A0A7P0T8A5 E7EVT8 ENST00000680704.1 L8E9S5 ENST00000681902.1 ENST00000680128.1 A0A7P0TA41 A0A7P0T9X9 ENST00000572259.2 A0A7P0T8I9 ENST00000389040.9 A0A7P0T8K1 A0A7P0TB16 ENST00000570650.2 ENST00000681661.1 ENST00000576149.5 ENST00000679865.1 A0A7P0TB80 ENST00000680069.1 [Q5VIR6-3] ENST00000571805.6 [Q5VIR6-1] ENST00000681423.1 A0A7P0T8A9 ENST00000681120.1 ENST00000639801.2 [Q5VIR6-4] A0A7P0T8P7 ENST00000571456.2 ENST00000681160.1 ENST00000679961.1 A0A7P0TA82 ENST00000681946.1 Q8NCR1 ENST00000639896.1 [Q5VIR6-1] ENST00000679817.1 A0A7P0T8D0 A0A7P0Z4Q7 ENST00000681943.1 A0A7P0T7U9 A0A7P0T9V8 ENST00000680114.1 ENST00000679680.1 ENST00000681096.1 I3L1W6 L8EC79 ENST00000681133.1 A0A7P0Z4K0 A0A7P0T8V1 ENST00000681154.1 F6VX93 ENST00000679959.1 ENST00000680641.1 ENST00000638350.1 [Q5VIR6-2] A0A7P0TAF8 ENST00000680970.1 A0A7P0T9B2 ENST00000680241.1 A0A7P0Z4M8 A0A7P0T804 A0A7P0T8V9 ENST00000401468.7 ENST00000575100.2 ENST00000679361.1 ENST00000291074.10 [Q5VIR6-2] A0A7P0Z400 A0A7P0TA79 ENST00000576019.6 A0A7P0T874 ENST00000437048.7 [Q5VIR6-4] ENST00000680872.1 A0A7P0TAE0 A0A7P0TBJ8 ENST00000574029.6 ENST00000681103.1 A0A7P0T805 A0A7P0TBK3 ENST00000681830.1 A0A7P0Z461 I3L4P9 A0A7P0T9B6 A0A7P0TA53 ENST00000681478.1 I3L184 ENST00000681229.1 Q5VIR6 ENST00000681917.1 ENST00000681858.1 ENST00000575207.6 ENST00000681050.1 A0A7P0TBG3 I3L0S6 |