VPS13A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	19 studies	31% ± 15%	Explore
glutamatergic neuron	12 studies	54% ± 27%	Explore
astrocyte	10 studies	32% ± 17%	Explore
oligodendrocyte precursor cell	10 studies	29% ± 11%	Explore
adipocyte	9 studies	25% ± 6%	Explore
ciliated cell	9 studies	27% ± 9%	Explore
natural killer cell	8 studies	18% ± 2%	Explore
type I pneumocyte	8 studies	31% ± 9%	Explore
GABAergic neuron	8 studies	44% ± 25%	Explore
macrophage	7 studies	21% ± 6%	Explore
epithelial cell	7 studies	40% ± 20%	Explore
T cell	6 studies	20% ± 3%	Explore
neuron	6 studies	27% ± 8%	Explore
interneuron	6 studies	45% ± 24%	Explore
club cell	6 studies	26% ± 9%	Explore
fibroblast	6 studies	25% ± 9%	Explore
smooth muscle cell	6 studies	22% ± 6%	Explore
basal cell	6 studies	33% ± 21%	Explore
endothelial cell of lymphatic vessel	6 studies	32% ± 10%	Explore
type II pneumocyte	6 studies	31% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 2%	Explore
cardiac muscle cell	5 studies	39% ± 9%	Explore
CD4-positive, alpha-beta T cell	4 studies	19% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	20% ± 2%	Explore
granule cell	4 studies	32% ± 6%	Explore
mucosal invariant T cell	4 studies	17% ± 1%	Explore
lymphocyte	4 studies	32% ± 12%	Explore
endothelial cell of vascular tree	4 studies	26% ± 11%	Explore
CD8-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
hepatocyte	4 studies	46% ± 15%	Explore
goblet cell	4 studies	32% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	17% ± 1%	Explore
ionocyte	3 studies	23% ± 5%	Explore
secretory cell	3 studies	20% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
GABAergic interneuron	3 studies	31% ± 5%	Explore
microglial cell	3 studies	36% ± 14%	Explore
mesothelial cell	3 studies	31% ± 10%	Explore
vein endothelial cell	3 studies	35% ± 15%	Explore
respiratory goblet cell	3 studies	26% ± 5%	Explore
neural progenitor cell	3 studies	21% ± 4%	Explore
enteroendocrine cell	3 studies	33% ± 3%	Explore
alveolar macrophage	3 studies	19% ± 2%	Explore
gamma-delta T cell	3 studies	19% ± 3%	Explore
transit amplifying cell	3 studies	42% ± 36%	Explore
brush cell	3 studies	20% ± 1%	Explore
oligodendrocyte	3 studies	33% ± 22%	Explore
mast cell	3 studies	27% ± 5%	Explore
mucus secreting cell	3 studies	28% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	37% ± 23%	Explore
lung	5 studies	22% ± 3%	Explore
heart	4 studies	26% ± 6%	Explore
liver	4 studies	28% ± 7%	Explore
adipose	3 studies	23% ± 1%	Explore
kidney	3 studies	24% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6072.58	1444 / 1445	100%	13.40	183 / 183
prostate	100%	4794.58	245 / 245	97%	8.45	487 / 502
pancreas	100%	3343.24	328 / 328	97%	8.46	172 / 178
thymus	100%	4326.88	653 / 653	97%	6.88	584 / 605
kidney	100%	3444.75	89 / 89	96%	10.58	867 / 901
lung	99%	3853.35	574 / 578	96%	6.93	1113 / 1155
intestine	100%	6640.94	966 / 966	96%	8.01	504 / 527
stomach	100%	4944.43	359 / 359	95%	8.86	273 / 286
breast	100%	3686.74	459 / 459	95%	7.67	1066 / 1118
bladder	100%	4838.19	21 / 21	94%	6.17	474 / 504
uterus	100%	4258.99	170 / 170	92%	6.19	421 / 459
adrenal gland	100%	4985.55	258 / 258	91%	6.12	210 / 230
skin	100%	5072.16	1809 / 1809	82%	4.38	385 / 472
brain	86%	2251.34	2271 / 2642	92%	5.04	648 / 705
ovary	100%	2314.66	180 / 180	73%	2.59	312 / 430
liver	100%	1877.08	225 / 226	67%	3.15	273 / 406
blood vessel	100%	7611.77	1335 / 1335	0%	0	0 / 0
muscle	100%	5803.37	803 / 803	0%	0	0 / 0
spleen	100%	4717.59	241 / 241	0%	0	0 / 0
adipose	100%	3402.26	1202 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	7.23	43 / 45
heart	95%	4302.15	816 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	76%	5.05	22 / 29
eye	0%	0	0 / 0	45%	1.82	36 / 80
peripheral blood	30%	1717.95	283 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0045053	Biological process	protein retention in Golgi apparatus
GO_0006623	Biological process	protein targeting to vacuole
GO_0030317	Biological process	flagellated sperm motility
GO_0007626	Biological process	locomotory behavior
GO_0030382	Biological process	sperm mitochondrion organization
GO_1905146	Biological process	lysosomal protein catabolic process
GO_0006914	Biological process	autophagy
GO_0008104	Biological process	protein localization
GO_0035176	Biological process	social behavior
GO_0007399	Biological process	nervous system development
GO_0006869	Biological process	lipid transport
GO_0006895	Biological process	Golgi to endosome transport
GO_0099013	Cellular component	neuronal dense core vesicle lumen
GO_0005811	Cellular component	lipid droplet
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0031966	Cellular component	mitochondrial membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0044233	Cellular component	mitochondria-associated endoplasmic reticulum membrane contact site
GO_0005829	Cellular component	cytosol
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0010008	Cellular component	endosome membrane
GO_0097225	Cellular component	sperm midpiece
GO_0005765	Cellular component	lysosomal membrane
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	VPS13A
Protein name	Intermembrane lipid transfer protein VPS13A (Chorea-acanthocytosis protein) (Chorein) (Vacuolar protein sorting-associated protein 13A) Vacuolar protein sorting 13 homolog A
Synonyms	KIAA0986 CHAC
Description	FUNCTION: Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids . Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria . Negatively regulates lipid droplet size and motility . Required for efficient lysosomal protein degradation . .
Accessions	ENST00000360280.8 [Q96RL7-1] ENST00000493341.1 ENST00000467124.1 H0YF78 ENST00000376636.7 [Q96RL7-3] Q96RL7 ENST00000643348.1 [Q96RL7-2] ENST00000419472.1 ENST00000645632.1 [Q96RL7-4] H0Y7P8 H0YG53

VPS13A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review