USP11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006508Biological processproteolysis
GO_0016579Biological processprotein deubiquitination
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0001222Molecular functiontranscription corepressor binding
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameUSP11
Protein nameUbiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
Ubiquitin specific peptidase 11
Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11)
SynonymshCG_17279
UHX1
DescriptionFUNCTION: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains . Inhibits the degradation of target proteins by the proteasome . Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) . Plays a role in the regulation of pathways leading to NF-kappa-B activation . Plays a role in the regulation of DNA repair after double-stranded DNA breaks . Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex . Promotes cell proliferation by deubiquitinating phosphorylated E2F1 . .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

AccessionsENST00000377080.7
C9JBP8
ENST00000377078.2
Q6P453
Q5JXD3
ENST00000377107.7
B4DGK3
G5E9A6
ENST00000218348.7
P51784