USP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	12 studies	28% ± 13%	Explore
B cell	10 studies	24% ± 6%	Explore
T cell	9 studies	25% ± 6%	Explore
CD8-positive, alpha-beta T cell	8 studies	26% ± 9%	Explore
CD4-positive, alpha-beta T cell	7 studies	26% ± 9%	Explore
endothelial cell	7 studies	22% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	23% ± 7%	Explore
fibroblast	6 studies	20% ± 4%	Explore
naive B cell	5 studies	17% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 2%	Explore
pro-B cell	5 studies	38% ± 12%	Explore
epithelial cell	5 studies	33% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	18% ± 3%	Explore
gamma-delta T cell	5 studies	24% ± 14%	Explore
plasmablast	4 studies	38% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	17% ± 2%	Explore
hematopoietic precursor cell	4 studies	33% ± 11%	Explore
non-classical monocyte	4 studies	21% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	17% ± 1%	Explore
precursor B cell	4 studies	44% ± 21%	Explore
retinal rod cell	4 studies	27% ± 10%	Explore
ciliated cell	4 studies	25% ± 9%	Explore
basal cell	4 studies	22% ± 6%	Explore
memory B cell	4 studies	19% ± 5%	Explore
regulatory T cell	4 studies	22% ± 7%	Explore
glutamatergic neuron	4 studies	23% ± 4%	Explore
plasmacytoid dendritic cell	4 studies	19% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
classical monocyte	3 studies	18% ± 2%	Explore
conventional dendritic cell	3 studies	38% ± 8%	Explore
connective tissue cell	3 studies	20% ± 2%	Explore
pericyte	3 studies	17% ± 1%	Explore
plasma cell	3 studies	28% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	20% ± 4%	Explore
innate lymphoid cell	3 studies	18% ± 2%	Explore
GABAergic neuron	3 studies	20% ± 2%	Explore
dendritic cell	3 studies	32% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	19% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	5 studies	23% ± 4%	Explore
brain	4 studies	19% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2200.24	1445 / 1445	100%	54.58	183 / 183
ovary	100%	2763.93	180 / 180	100%	50.55	429 / 430
brain	100%	1633.31	2639 / 2642	100%	46.17	704 / 705
breast	100%	2233.15	459 / 459	100%	71.94	1115 / 1118
lung	100%	1914.28	576 / 578	100%	48.62	1155 / 1155
uterus	100%	2661.49	170 / 170	99%	80.40	456 / 459
prostate	100%	1763.07	245 / 245	99%	35.51	496 / 502
thymus	100%	1890.34	653 / 653	99%	39.41	597 / 605
intestine	100%	2191.71	966 / 966	98%	46.25	517 / 527
pancreas	99%	1182.88	326 / 328	98%	32.62	175 / 178
stomach	100%	1630.00	359 / 359	98%	45.12	279 / 286
bladder	100%	1999.00	21 / 21	97%	47.34	490 / 504
skin	100%	2570.01	1809 / 1809	91%	45.47	428 / 472
kidney	100%	1230.78	89 / 89	88%	25.54	793 / 901
adrenal gland	100%	1432.02	258 / 258	83%	17.40	191 / 230
liver	100%	750.30	226 / 226	79%	18.33	319 / 406
adipose	100%	2081.49	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	50.02	29 / 29
spleen	100%	2090.65	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	85.82	45 / 45
ureter	0%	0	0 / 0	100%	14.32	1 / 1
blood vessel	100%	2266.79	1334 / 1335	0%	0	0 / 0
muscle	100%	1220.13	799 / 803	0%	0	0 / 0
heart	97%	1008.14	838 / 861	0%	0	0 / 0
peripheral blood	75%	1816.89	694 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	51%	9.61	41 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001501	Biological process	skeletal system development
GO_0006282	Biological process	regulation of DNA repair
GO_0009411	Biological process	response to UV
GO_0006281	Biological process	DNA repair
GO_0035520	Biological process	monoubiquitinated protein deubiquitination
GO_0006508	Biological process	proteolysis
GO_0046427	Biological process	positive regulation of receptor signaling pathway via JAK-STAT
GO_0016579	Biological process	protein deubiquitination
GO_1904333	Biological process	positive regulation of error-prone translesion synthesis
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0008233	Molecular function	peptidase activity
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0004843	Molecular function	cysteine-type deubiquitinase activity

IV. Literature review

[source]

Gene name	USP1
Protein name	Ubiquitin specific peptidase 1 Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment]
Synonyms
Description	FUNCTION: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 . Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA . Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity . .
Accessions	C9JC88 ENST00000452143.5 C9JWX4 O94782 ENST00000442679.5 ENST00000339950.5 ENST00000371146.5

USP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review