UPP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	25 studies	25% ± 8%	Explore
endothelial cell	25 studies	28% ± 10%	Explore
classical monocyte	24 studies	44% ± 14%	Explore
macrophage	22 studies	36% ± 14%	Explore
non-classical monocyte	21 studies	40% ± 13%	Explore
monocyte	15 studies	38% ± 14%	Explore
conventional dendritic cell	14 studies	29% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	28% ± 6%	Explore
endothelial cell of vascular tree	11 studies	41% ± 13%	Explore
CD8-positive, alpha-beta T cell	10 studies	22% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	25% ± 4%	Explore
CD4-positive, alpha-beta T cell	10 studies	24% ± 5%	Explore
mature NK T cell	10 studies	24% ± 3%	Explore
gamma-delta T cell	10 studies	25% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	19% ± 3%	Explore
mucosal invariant T cell	9 studies	21% ± 4%	Explore
vein endothelial cell	9 studies	32% ± 14%	Explore
alveolar macrophage	8 studies	44% ± 13%	Explore
dendritic cell	8 studies	34% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	23% ± 8%	Explore
regulatory T cell	8 studies	23% ± 6%	Explore
myeloid cell	7 studies	35% ± 16%	Explore
neutrophil	6 studies	23% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	24% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	24% ± 6%	Explore
mononuclear phagocyte	5 studies	26% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	24% ± 5%	Explore
epithelial cell	5 studies	26% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	26% ± 6%	Explore
T cell	4 studies	19% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	27% ± 6%	Explore
leukocyte	4 studies	29% ± 10%	Explore
inflammatory macrophage	4 studies	26% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
endothelial cell of artery	4 studies	22% ± 6%	Explore
basal cell	4 studies	19% ± 3%	Explore
squamous epithelial cell	3 studies	45% ± 12%	Explore
pericyte	3 studies	25% ± 5%	Explore
kidney loop of Henle epithelial cell	3 studies	23% ± 5%	Explore
innate lymphoid cell	3 studies	23% ± 4%	Explore
tissue-resident macrophage	3 studies	24% ± 4%	Explore
intermediate monocyte	3 studies	66% ± 7%	Explore
GABAergic neuron	3 studies	42% ± 15%	Explore
T-helper 1 cell	3 studies	23% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	24% ± 5%	Explore
interneuron	3 studies	34% ± 23%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	28% ± 8%	Explore
lung	8 studies	27% ± 11%	Explore
brain	5 studies	23% ± 7%	Explore
kidney	3 studies	19% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	4061.15	89 / 89	98%	37.40	887 / 901
bladder	100%	1626.10	21 / 21	97%	38.04	488 / 504
lung	100%	3660.94	577 / 578	96%	42.61	1112 / 1155
adrenal gland	100%	1695.00	257 / 258	95%	25.79	218 / 230
thymus	99%	1599.25	648 / 653	91%	37.35	552 / 605
esophagus	90%	3155.23	1299 / 1445	95%	35.47	174 / 183
uterus	93%	970.74	158 / 170	92%	38.88	422 / 459
intestine	90%	1117.21	872 / 966	93%	18.27	489 / 527
skin	74%	949.16	1336 / 1809	99%	77.20	465 / 472
brain	95%	1652.86	2521 / 2642	69%	18.03	485 / 705
breast	99%	2177.10	455 / 459	46%	6.54	516 / 1118
stomach	43%	424.79	156 / 359	90%	13.95	257 / 286
liver	71%	841.76	160 / 226	62%	9.56	253 / 406
pancreas	30%	217.92	100 / 328	96%	28.33	171 / 178
prostate	88%	998.94	216 / 245	21%	2.40	105 / 502
spleen	100%	3315.78	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	54.16	1 / 1
adipose	100%	2960.08	1199 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	38.27	44 / 45
peripheral blood	96%	10099.87	891 / 929	0%	0	0 / 0
heart	94%	1325.87	812 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	16.78	27 / 29
blood vessel	92%	1324.23	1225 / 1335	0%	0	0 / 0
ovary	26%	203.15	46 / 180	47%	6.65	203 / 430
eye	0%	0	0 / 0	48%	5.51	38 / 80
muscle	47%	367.87	378 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006139	Biological process	nucleobase-containing compound metabolic process
GO_0006218	Biological process	uridine catabolic process
GO_0042149	Biological process	cellular response to glucose starvation
GO_0044206	Biological process	UMP salvage
GO_0046050	Biological process	UMP catabolic process
GO_0046079	Biological process	dUMP catabolic process
GO_0006248	Biological process	CMP catabolic process
GO_0046074	Biological process	dTMP catabolic process
GO_0006249	Biological process	dCMP catabolic process
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0004850	Molecular function	uridine phosphorylase activity
GO_0009032	Molecular function	thymidine phosphorylase activity
GO_0047847	Molecular function	deoxyuridine phosphorylase activity
GO_0042802	Molecular function	identical protein binding

IV. Literature review

[source]

Gene name	UPP1
Protein name	Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) Uridine phosphorylase 1
Synonyms	UP
Description	FUNCTION: Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis . Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (Probable). .
Accessions	ENST00000436673.5 F8WD51 C9JIP2 ENST00000457596.5 [Q16831-2] ENST00000395564.9 [Q16831-1] ENST00000444999.5 ENST00000432131.5 ENST00000416681.5 ENST00000331803.8 [Q16831-1] Q16831 ENST00000417464.6 [Q16831-2] C9K0J2 C9J486 ENST00000395560.7 [Q16831-2]

UPP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review