UHRF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0016925Biological processprotein sumoylation
GO_0051865Biological processprotein autoubiquitination
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_0030154Biological processcell differentiation
GO_0051726Biological processregulation of cell cycle
GO_0000792Cellular componentheterochromatin
GO_0005654Cellular componentnucleoplasm
GO_0005721Cellular componentpericentric heterochromatin
GO_0005634Cellular componentnucleus
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0019789Molecular functionSUMO transferase activity
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameUHRF2
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
Ubiquitin like with PHD and ring finger domains 2
E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2)
SynonymsRNF107
NIRF
DescriptionFUNCTION: E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair . Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them . This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest . Ubiquitinates also PCNP leading to its degradation by the proteasome . Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation . Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation . Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation . .

FUNCTION: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications. .

AccessionsENST00000381373.3
A0A0A0MSQ3
ENST00000468435.6 [Q96PU4-2]
B1AL33
ENST00000450508.1
Q96PU4
ENST00000276893.10 [Q96PU4-1]