Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 28% ± 8% | |
B cell | 9 studies | 21% ± 5% | |
endothelial cell of lymphatic vessel | 9 studies | 34% ± 16% | |
oligodendrocyte | 9 studies | 30% ± 10% | |
GABAergic neuron | 8 studies | 35% ± 17% | |
T cell | 7 studies | 21% ± 6% | |
oligodendrocyte precursor cell | 7 studies | 29% ± 12% | |
macrophage | 7 studies | 27% ± 7% | |
microglial cell | 6 studies | 28% ± 7% | |
fibroblast | 6 studies | 22% ± 4% | |
natural killer cell | 5 studies | 17% ± 1% | |
glutamatergic neuron | 5 studies | 51% ± 15% | |
lymphocyte | 5 studies | 25% ± 10% | |
regulatory T cell | 5 studies | 19% ± 4% | |
astrocyte | 5 studies | 30% ± 8% | |
interneuron | 5 studies | 40% ± 22% | |
precursor B cell | 4 studies | 32% ± 7% | |
epithelial cell | 4 studies | 29% ± 7% | |
pericyte | 4 studies | 21% ± 6% | |
smooth muscle cell | 4 studies | 19% ± 1% | |
CD8-positive, alpha-beta memory T cell | 4 studies | 17% ± 2% | |
naive B cell | 4 studies | 19% ± 4% | |
CD4-positive, alpha-beta T cell | 3 studies | 22% ± 3% | |
CD8-positive, alpha-beta T cell | 3 studies | 20% ± 3% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 21% ± 2% | |
monocyte | 3 studies | 19% ± 2% | |
type I pneumocyte | 3 studies | 21% ± 6% | |
transit amplifying cell | 3 studies | 31% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2942.94 | 1445 / 1445 | 100% | 14.47 | 183 / 183 |
prostate | 100% | 3966.14 | 245 / 245 | 100% | 15.81 | 501 / 502 |
breast | 100% | 4298.59 | 459 / 459 | 100% | 15.16 | 1113 / 1118 |
lung | 100% | 3382.75 | 578 / 578 | 99% | 12.42 | 1147 / 1155 |
uterus | 100% | 4473.25 | 170 / 170 | 99% | 16.54 | 455 / 459 |
pancreas | 100% | 2023.95 | 328 / 328 | 99% | 12.23 | 176 / 178 |
bladder | 100% | 3727.43 | 21 / 21 | 99% | 13.08 | 497 / 504 |
thymus | 100% | 3929.96 | 653 / 653 | 99% | 12.28 | 596 / 605 |
intestine | 100% | 3699.91 | 966 / 966 | 98% | 12.40 | 519 / 527 |
ovary | 100% | 4402.43 | 180 / 180 | 98% | 9.52 | 422 / 430 |
stomach | 100% | 2550.48 | 359 / 359 | 98% | 12.11 | 279 / 286 |
brain | 98% | 2200.96 | 2577 / 2642 | 100% | 11.67 | 703 / 705 |
kidney | 100% | 2107.29 | 89 / 89 | 94% | 9.27 | 851 / 901 |
skin | 100% | 3776.64 | 1809 / 1809 | 93% | 11.38 | 437 / 472 |
adrenal gland | 100% | 2587.44 | 258 / 258 | 90% | 6.83 | 207 / 230 |
liver | 100% | 1341.69 | 226 / 226 | 77% | 5.22 | 312 / 406 |
adipose | 100% | 3981.29 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 24.14 | 29 / 29 |
spleen | 100% | 4571.16 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 14.98 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.31 | 1 / 1 |
blood vessel | 100% | 3586.93 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 1652.95 | 797 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1446.55 | 832 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 88% | 2316.30 | 821 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 68% | 4.92 | 54 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0016925 | Biological process | protein sumoylation |
GO_0051865 | Biological process | protein autoubiquitination |
GO_0044027 | Biological process | negative regulation of gene expression via chromosomal CpG island methylation |
GO_0030154 | Biological process | cell differentiation |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0000792 | Cellular component | heterochromatin |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005721 | Cellular component | pericentric heterochromatin |
GO_0005634 | Cellular component | nucleus |
GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
GO_0003677 | Molecular function | DNA binding |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0019789 | Molecular function | SUMO transferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0042393 | Molecular function | histone binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | UHRF2 |
Protein name | RING-type E3 ubiquitin transferase (EC 2.3.2.27) Ubiquitin like with PHD and ring finger domains 2 E3 ubiquitin-protein ligase UHRF2 (EC 2.3.2.27) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear protein 97) (Nuclear zinc finger protein Np97) (RING finger protein 107) (RING-type E3 ubiquitin transferase UHRF2) (Ubiquitin-like PHD and RING finger domain-containing protein 2) (Ubiquitin-like-containing PHD and RING finger domains protein 2) |
Synonyms | RNF107 NIRF |
Description | FUNCTION: E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair . Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them . This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest . Ubiquitinates also PCNP leading to its degradation by the proteasome . Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation . Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation . Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation . . FUNCTION: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications. . |
Accessions | ENST00000381373.3 A0A0A0MSQ3 ENST00000468435.6 [Q96PU4-2] B1AL33 ENST00000450508.1 Q96PU4 ENST00000276893.10 [Q96PU4-1] |