Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 28% ± 15% | |
classical monocyte | 13 studies | 28% ± 10% | |
astrocyte | 12 studies | 34% ± 16% | |
monocyte | 10 studies | 21% ± 4% | |
macrophage | 10 studies | 28% ± 11% | |
epithelial cell | 10 studies | 31% ± 16% | |
pericyte | 9 studies | 27% ± 14% | |
fibroblast | 9 studies | 23% ± 10% | |
ciliated cell | 8 studies | 24% ± 8% | |
glutamatergic neuron | 8 studies | 39% ± 28% | |
microglial cell | 8 studies | 26% ± 11% | |
myeloid cell | 8 studies | 28% ± 9% | |
oligodendrocyte precursor cell | 7 studies | 29% ± 10% | |
basal cell | 7 studies | 24% ± 12% | |
neuron | 6 studies | 32% ± 14% | |
interneuron | 6 studies | 37% ± 23% | |
B cell | 6 studies | 19% ± 2% | |
GABAergic neuron | 6 studies | 45% ± 24% | |
oligodendrocyte | 6 studies | 26% ± 9% | |
smooth muscle cell | 6 studies | 23% ± 5% | |
secretory cell | 5 studies | 22% ± 6% | |
adipocyte | 5 studies | 23% ± 2% | |
T cell | 5 studies | 20% ± 7% | |
endothelial cell of lymphatic vessel | 5 studies | 26% ± 7% | |
non-classical monocyte | 4 studies | 21% ± 8% | |
club cell | 4 studies | 19% ± 3% | |
cardiac muscle cell | 4 studies | 21% ± 3% | |
lymphocyte | 4 studies | 26% ± 7% | |
type II pneumocyte | 4 studies | 18% ± 4% | |
dendritic cell | 4 studies | 27% ± 12% | |
type I pneumocyte | 4 studies | 22% ± 4% | |
keratinocyte | 4 studies | 27% ± 8% | |
mast cell | 4 studies | 22% ± 3% | |
ionocyte | 3 studies | 22% ± 5% | |
hematopoietic precursor cell | 3 studies | 28% ± 5% | |
GABAergic interneuron | 3 studies | 28% ± 11% | |
granule cell | 3 studies | 22% ± 5% | |
retinal ganglion cell | 3 studies | 27% ± 8% | |
squamous epithelial cell | 3 studies | 35% ± 20% | |
respiratory goblet cell | 3 studies | 23% ± 3% | |
hepatocyte | 3 studies | 48% ± 20% | |
natural killer cell | 3 studies | 17% ± 1% | |
goblet cell | 3 studies | 35% ± 19% | |
brush cell | 3 studies | 16% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 18034.97 | 1445 / 1445 | 100% | 40.62 | 183 / 183 |
stomach | 100% | 15329.53 | 359 / 359 | 99% | 25.19 | 284 / 286 |
intestine | 100% | 16028.45 | 966 / 966 | 99% | 22.75 | 523 / 527 |
lung | 100% | 17931.08 | 578 / 578 | 99% | 22.80 | 1145 / 1155 |
skin | 100% | 18926.67 | 1808 / 1809 | 99% | 26.50 | 468 / 472 |
breast | 100% | 13940.87 | 459 / 459 | 99% | 26.57 | 1105 / 1118 |
bladder | 100% | 23368.10 | 21 / 21 | 99% | 18.90 | 497 / 504 |
prostate | 100% | 16020.73 | 245 / 245 | 99% | 22.83 | 495 / 502 |
thymus | 100% | 15813.01 | 653 / 653 | 99% | 20.36 | 596 / 605 |
ovary | 100% | 18967.84 | 180 / 180 | 98% | 18.13 | 420 / 430 |
uterus | 100% | 17486.01 | 170 / 170 | 97% | 19.88 | 446 / 459 |
kidney | 100% | 13164.67 | 89 / 89 | 97% | 21.00 | 874 / 901 |
pancreas | 98% | 7600.43 | 323 / 328 | 98% | 20.38 | 174 / 178 |
brain | 94% | 8535.81 | 2495 / 2642 | 100% | 23.87 | 702 / 705 |
liver | 100% | 8766.82 | 226 / 226 | 87% | 10.89 | 355 / 406 |
adrenal gland | 100% | 15174.71 | 258 / 258 | 87% | 11.73 | 201 / 230 |
adipose | 100% | 14166.69 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 17328.95 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 21686.20 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 13087.89 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.01 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 99% | 17.71 | 79 / 80 |
tonsil | 0% | 0 | 0 / 0 | 98% | 24.29 | 44 / 45 |
peripheral blood | 95% | 10486.34 | 879 / 929 | 0% | 0 | 0 / 0 |
heart | 94% | 8573.42 | 812 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 18.24 | 27 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0071629 | Biological process | cytoplasm protein quality control by the ubiquitin-proteasome system |
GO_0070979 | Biological process | protein K11-linked ubiquitination |
GO_0071596 | Biological process | ubiquitin-dependent protein catabolic process via the N-end rule pathway |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0044314 | Biological process | protein K27-linked ubiquitination |
GO_0010508 | Biological process | positive regulation of autophagy |
GO_0045717 | Biological process | negative regulation of fatty acid biosynthetic process |
GO_0007032 | Biological process | endosome organization |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0140455 | Biological process | cytoplasm protein quality control |
GO_0035579 | Cellular component | specific granule membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005813 | Cellular component | centrosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0070821 | Cellular component | tertiary granule membrane |
GO_0101003 | Cellular component | ficolin-1-rich granule membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005768 | Cellular component | endosome |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0008270 | Molecular function | zinc ion binding |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005516 | Molecular function | calmodulin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | UBR4 |
Protein name | E3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (RING-type E3 ubiquitin transferase UBR4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1) Ubiquitin protein ligase E3 component n-recognin 4 Alternative protein UBR4 UBR4 protein |
Synonyms | ZUBR1 KIAA1307 RBAF600 KIAA0462 |
Description | FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. . |
Accessions | ENST00000375225.7 ENST00000417040.1 X6R960 Q5T4S7 Q96HY5 ENST00000425413.5 ENST00000375254.8 [Q5T4S7-1] L0R6T5 X6RE05 ENST00000375218.3 [Q5T4S7-6] A0A0A0MSW0 Q5TBN9 ENST00000375224.1 |