UBR4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071629Biological processcytoplasm protein quality control by the ubiquitin-proteasome system
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0071596Biological processubiquitin-dependent protein catabolic process via the N-end rule pathway
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0044314Biological processprotein K27-linked ubiquitination
GO_0010508Biological processpositive regulation of autophagy
GO_0045717Biological processnegative regulation of fatty acid biosynthetic process
GO_0007032Biological processendosome organization
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0140455Biological processcytoplasm protein quality control
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0070821Cellular componenttertiary granule membrane
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBR4
Protein nameE3 ubiquitin-protein ligase UBR4 (EC 2.3.2.27) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (RING-type E3 ubiquitin transferase UBR4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1)
Ubiquitin protein ligase E3 component n-recognin 4
Alternative protein UBR4
UBR4 protein
SynonymsZUBR1
KIAA1307
RBAF600
KIAA0462
DescriptionFUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. .

AccessionsENST00000375225.7
ENST00000417040.1
X6R960
Q5T4S7
Q96HY5
ENST00000425413.5
ENST00000375254.8 [Q5T4S7-1]
L0R6T5
X6RE05
ENST00000375218.3 [Q5T4S7-6]
A0A0A0MSW0
Q5TBN9
ENST00000375224.1