UBR3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045732Biological processpositive regulation of protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0042048Biological processolfactory behavior
GO_0007608Biological processsensory perception of smell
GO_0009792Biological processembryo development ending in birth or egg hatching
GO_1904878Biological processnegative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO_0001701Biological processin utero embryonic development
GO_0071596Biological processubiquitin-dependent protein catabolic process via the N-end rule pathway
GO_0001967Biological processsuckling behavior
GO_0000151Cellular componentubiquitin ligase complex
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameUBR3
Protein nameE3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650)
E3 ubiquitin-protein ligase (EC 2.3.2.27)
Ubiquitin protein ligase E3 component n-recognin 3
SynonymsZNF650
KIAA2024
DescriptionFUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A . .

FUNCTION: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. .

FUNCTION: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. .

FUNCTION: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. .

AccessionsH0Y3K2
F8WEB7
ENST00000439681.1
H7BZD8
ENST00000430321.5
H7C481
Q6ZT12
ENST00000392632.6
ENST00000272793.11 [Q6ZT12-1]
ENST00000444475.5