Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 23 studies | 39% ± 16% | |
astrocyte | 19 studies | 44% ± 20% | |
oligodendrocyte | 16 studies | 48% ± 17% | |
oligodendrocyte precursor cell | 15 studies | 48% ± 18% | |
microglial cell | 14 studies | 43% ± 12% | |
glutamatergic neuron | 13 studies | 59% ± 24% | |
GABAergic neuron | 11 studies | 59% ± 23% | |
macrophage | 11 studies | 35% ± 17% | |
fibroblast | 11 studies | 42% ± 16% | |
smooth muscle cell | 10 studies | 35% ± 12% | |
pericyte | 9 studies | 42% ± 17% | |
adipocyte | 9 studies | 57% ± 13% | |
epithelial cell | 8 studies | 33% ± 20% | |
neuron | 7 studies | 47% ± 21% | |
interneuron | 7 studies | 62% ± 26% | |
endothelial cell of lymphatic vessel | 7 studies | 37% ± 18% | |
retinal ganglion cell | 6 studies | 45% ± 24% | |
cardiac muscle cell | 5 studies | 61% ± 16% | |
dendritic cell | 5 studies | 22% ± 2% | |
mast cell | 5 studies | 28% ± 9% | |
ciliated cell | 5 studies | 22% ± 7% | |
Mueller cell | 5 studies | 45% ± 16% | |
retinal cone cell | 5 studies | 44% ± 19% | |
retina horizontal cell | 5 studies | 49% ± 23% | |
T cell | 5 studies | 23% ± 6% | |
monocyte | 5 studies | 30% ± 8% | |
type I pneumocyte | 5 studies | 35% ± 10% | |
type II pneumocyte | 5 studies | 34% ± 9% | |
basal cell | 5 studies | 35% ± 24% | |
granule cell | 4 studies | 53% ± 14% | |
plasma cell | 4 studies | 30% ± 7% | |
mesothelial cell | 4 studies | 34% ± 15% | |
amacrine cell | 4 studies | 54% ± 15% | |
retinal rod cell | 4 studies | 49% ± 11% | |
myeloid cell | 4 studies | 29% ± 8% | |
club cell | 4 studies | 34% ± 10% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 50% ± 3% | |
GABAergic interneuron | 3 studies | 64% ± 6% | |
progenitor cell | 3 studies | 31% ± 1% | |
CD4-positive, alpha-beta T cell | 3 studies | 20% ± 2% | |
vein endothelial cell | 3 studies | 38% ± 22% | |
GABAergic amacrine cell | 3 studies | 59% ± 17% | |
OFF-bipolar cell | 3 studies | 46% ± 22% | |
ON-bipolar cell | 3 studies | 46% ± 20% | |
glycinergic amacrine cell | 3 studies | 50% ± 12% | |
endothelial cell of vascular tree | 3 studies | 40% ± 23% | |
hepatocyte | 3 studies | 62% ± 16% | |
retinal pigment epithelial cell | 3 studies | 47% ± 27% | |
neural progenitor cell | 3 studies | 41% ± 2% | |
ependymal cell | 3 studies | 41% ± 18% | |
B cell | 3 studies | 28% ± 7% | |
alveolar macrophage | 3 studies | 37% ± 8% | |
capillary endothelial cell | 3 studies | 26% ± 6% | |
natural killer cell | 3 studies | 24% ± 5% | |
respiratory goblet cell | 3 studies | 37% ± 15% | |
muscle cell | 3 studies | 52% ± 31% | |
goblet cell | 3 studies | 40% ± 31% | |
mucus secreting cell | 3 studies | 33% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3455.83 | 1445 / 1445 | 100% | 24.21 | 183 / 183 |
breast | 100% | 3865.11 | 459 / 459 | 99% | 22.90 | 1110 / 1118 |
prostate | 100% | 3059.48 | 244 / 245 | 100% | 24.89 | 500 / 502 |
lung | 99% | 3193.70 | 575 / 578 | 100% | 16.88 | 1151 / 1155 |
brain | 99% | 3934.01 | 2628 / 2642 | 100% | 22.17 | 702 / 705 |
thymus | 100% | 3951.12 | 653 / 653 | 98% | 21.77 | 594 / 605 |
stomach | 100% | 2555.82 | 359 / 359 | 98% | 15.78 | 280 / 286 |
adrenal gland | 100% | 5241.01 | 258 / 258 | 98% | 15.86 | 225 / 230 |
intestine | 100% | 3466.81 | 966 / 966 | 97% | 14.17 | 513 / 527 |
bladder | 100% | 3703.33 | 21 / 21 | 97% | 13.12 | 488 / 504 |
pancreas | 98% | 1783.40 | 323 / 328 | 98% | 13.26 | 175 / 178 |
uterus | 100% | 3643.46 | 170 / 170 | 96% | 13.17 | 442 / 459 |
liver | 100% | 2467.65 | 226 / 226 | 95% | 11.04 | 387 / 406 |
kidney | 100% | 1996.53 | 89 / 89 | 95% | 15.64 | 858 / 901 |
ovary | 100% | 3149.25 | 180 / 180 | 95% | 9.51 | 409 / 430 |
skin | 100% | 3923.15 | 1809 / 1809 | 93% | 14.39 | 438 / 472 |
blood vessel | 100% | 4634.46 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 18573.33 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2178.97 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.36 | 1 / 1 |
adipose | 100% | 4135.38 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 96% | 5885.80 | 829 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 12.52 | 43 / 45 |
eye | 0% | 0 | 0 / 0 | 68% | 7.05 | 54 / 80 |
lymph node | 0% | 0 | 0 / 0 | 62% | 5.92 | 18 / 29 |
peripheral blood | 60% | 1064.67 | 553 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045732 | Biological process | positive regulation of protein catabolic process |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0042048 | Biological process | olfactory behavior |
GO_0007608 | Biological process | sensory perception of smell |
GO_0009792 | Biological process | embryo development ending in birth or egg hatching |
GO_1904878 | Biological process | negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
GO_0001701 | Biological process | in utero embryonic development |
GO_0071596 | Biological process | ubiquitin-dependent protein catabolic process via the N-end rule pathway |
GO_0001967 | Biological process | suckling behavior |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0008270 | Molecular function | zinc ion binding |
Gene name | UBR3 |
Protein name | E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650) E3 ubiquitin-protein ligase (EC 2.3.2.27) Ubiquitin protein ligase E3 component n-recognin 3 |
Synonyms | ZNF650 KIAA2024 |
Description | FUNCTION: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A . . FUNCTION: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. . FUNCTION: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. . FUNCTION: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. . |
Accessions | H0Y3K2 F8WEB7 ENST00000439681.1 H7BZD8 ENST00000430321.5 H7C481 Q6ZT12 ENST00000392632.6 ENST00000272793.11 [Q6ZT12-1] ENST00000444475.5 |