TXK | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	39 studies	37% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	17 studies	42% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	48% ± 14%	Explore
T cell	11 studies	22% ± 5%	Explore
mature NK T cell	11 studies	34% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	29% ± 8%	Explore
CD4-positive, alpha-beta T cell	9 studies	26% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	25% ± 9%	Explore
innate lymphoid cell	8 studies	37% ± 17%	Explore
gamma-delta T cell	6 studies	29% ± 8%	Explore
regulatory T cell	5 studies	22% ± 2%	Explore
CD8-positive, alpha-beta T cell	5 studies	26% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	29% ± 8%	Explore
mucosal invariant T cell	4 studies	26% ± 5%	Explore
lymphocyte	4 studies	32% ± 6%	Explore
glutamatergic neuron	3 studies	26% ± 11%	Explore
macrophage	3 studies	18% ± 1%	Explore
type I pneumocyte	3 studies	17% ± 2%	Explore
T follicular helper cell	3 studies	24% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	18% ± 1%	Explore
lymph node	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	140.18	89 / 89	68%	2.07	609 / 901
thymus	100%	161.88	652 / 653	54%	1.21	325 / 605
lung	100%	327.45	578 / 578	47%	1.16	546 / 1155
pancreas	82%	43.10	268 / 328	56%	1.55	99 / 178
bladder	86%	132.71	18 / 21	44%	1.40	224 / 504
skin	73%	102.26	1323 / 1809	46%	1.38	215 / 472
adrenal gland	99%	109.83	256 / 258	15%	0.34	34 / 230
breast	93%	75.22	428 / 459	20%	0.48	229 / 1118
esophagus	71%	76.77	1019 / 1445	43%	0.92	78 / 183
stomach	79%	59.51	284 / 359	31%	0.57	89 / 286
liver	99%	126.04	224 / 226	11%	0.23	45 / 406
uterus	75%	50.06	127 / 170	35%	0.89	162 / 459
intestine	78%	227.69	750 / 966	30%	0.63	156 / 527
prostate	88%	68.58	215 / 245	15%	0.24	75 / 502
ovary	31%	18.33	55 / 180	70%	2.59	302 / 430
spleen	100%	1131.92	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	1.80	1 / 1
peripheral blood	99%	556.46	920 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	3.88	28 / 29
adipose	96%	95.98	1156 / 1204	0%	0	0 / 0
blood vessel	71%	49.57	947 / 1335	0%	0	0 / 0
heart	64%	32.45	551 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	44%	0.83	20 / 45
muscle	30%	12.24	240 / 803	0%	0	0 / 0
brain	18%	8.14	464 / 2642	2%	0.05	16 / 705
eye	0%	0	0 / 0	3%	0.05	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060335	Biological process	positive regulation of type II interferon-mediated signaling pathway
GO_0002250	Biological process	adaptive immune response
GO_0010468	Biological process	regulation of gene expression
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0001819	Biological process	positive regulation of cytokine production
GO_0006468	Biological process	protein phosphorylation
GO_0046777	Biological process	protein autophosphorylation
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0004715	Molecular function	non-membrane spanning protein tyrosine kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TXK
Protein name	Tyrosine kinase TXK tyrosine kinase Tyrosine-protein kinase (EC 2.7.10.2) Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase)
Synonyms	RLK PTK4 hCG_17408
Description	FUNCTION: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 . Within the complex, phosphorylates both PARP1 and EEF1A1 . Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. .
Accessions	V9GZ99 ENST00000509681.1 Q6LD13 ENST00000507351.1 V9GZA3 D6R9F2 E7EQN8 D6RA14 Q6LD14 ENST00000264316.9 ENST00000514937.5 ENST00000506073.2 P42681 D6RBM7

TXK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review