TTN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	16 studies	25% ± 6%	Explore
regulatory T cell	14 studies	27% ± 10%	Explore
endothelial cell of lymphatic vessel	10 studies	40% ± 20%	Explore
type II pneumocyte	10 studies	47% ± 18%	Explore
endothelial cell	9 studies	41% ± 26%	Explore
mast cell	7 studies	46% ± 24%	Explore
pericyte	7 studies	32% ± 26%	Explore
macrophage	7 studies	33% ± 20%	Explore
memory B cell	6 studies	18% ± 1%	Explore
cardiac muscle cell	6 studies	97% ± 3%	Explore
astrocyte	6 studies	43% ± 17%	Explore
lymphocyte	5 studies	34% ± 28%	Explore
glutamatergic neuron	5 studies	40% ± 22%	Explore
T cell	4 studies	18% ± 1%	Explore
adipocyte	4 studies	41% ± 21%	Explore
fibroblast	4 studies	40% ± 30%	Explore
GABAergic neuron	4 studies	36% ± 21%	Explore
interneuron	4 studies	38% ± 22%	Explore
CD8-positive, alpha-beta T cell	3 studies	27% ± 7%	Explore
myeloid cell	3 studies	47% ± 31%	Explore
neuron	3 studies	24% ± 1%	Explore
smooth muscle cell	3 studies	43% ± 32%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
heart	6 studies	47% ± 22%	Explore
brain	5 studies	36% ± 21%	Explore
lung	3 studies	21% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
heart	100%	235458.64	861 / 861	0%	0	0 / 0
muscle	100%	1192301.02	803 / 803	0%	0	0 / 0
thymus	78%	2177.77	507 / 653	2%	0.06	11 / 605
pancreas	72%	2004.05	235 / 328	1%	0.08	2 / 178
lung	67%	3255.81	385 / 578	3%	0.18	29 / 1155
spleen	63%	1608.34	151 / 241	0%	0	0 / 0
ovary	57%	1218.35	102 / 180	0%	0	0 / 430
breast	46%	1472.27	209 / 459	2%	0.14	24 / 1118
prostate	40%	3106.88	98 / 245	8%	0.50	38 / 502
uterus	43%	942.25	73 / 170	4%	0.44	17 / 459
adipose	47%	1184.91	560 / 1204	0%	0	0 / 0
esophagus	39%	1262.35	566 / 1445	3%	0.05	6 / 183
intestine	37%	869.50	357 / 966	1%	0.03	7 / 527
blood vessel	35%	1901.12	466 / 1335	0%	0	0 / 0
peripheral blood	30%	923.92	278 / 929	0%	0	0 / 0
adrenal gland	24%	517.32	62 / 258	0%	0.01	1 / 230
stomach	19%	408.37	70 / 359	2%	0.13	7 / 286
skin	19%	1022.58	341 / 1809	1%	0.01	4 / 472
lymph node	0%	0	0 / 0	14%	0.19	4 / 29
tonsil	0%	0	0 / 0	9%	0.56	4 / 45
kidney	7%	131.97	6 / 89	2%	0.10	14 / 901
bladder	5%	79.38	1 / 21	2%	0.10	11 / 504
brain	5%	118.81	134 / 2642	1%	0.01	6 / 705
liver	3%	61.90	6 / 226	0%	0.00	1 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006941	Biological process	striated muscle contraction
GO_0048769	Biological process	sarcomerogenesis
GO_0055013	Biological process	cardiac muscle cell development
GO_0010628	Biological process	positive regulation of gene expression
GO_0003300	Biological process	cardiac muscle hypertrophy
GO_0010737	Biological process	protein kinase A signaling
GO_0006936	Biological process	muscle contraction
GO_0060048	Biological process	cardiac muscle contraction
GO_0055003	Biological process	cardiac myofibril assembly
GO_0030241	Biological process	skeletal muscle myosin thick filament assembly
GO_0050714	Biological process	positive regulation of protein secretion
GO_0055008	Biological process	cardiac muscle tissue morphogenesis
GO_0035995	Biological process	detection of muscle stretch
GO_0007076	Biological process	mitotic chromosome condensation
GO_0045214	Biological process	sarcomere organization
GO_0051592	Biological process	response to calcium ion
GO_0030240	Biological process	skeletal muscle thin filament assembly
GO_0005576	Cellular component	extracellular region
GO_0030018	Cellular component	Z disc
GO_0070062	Cellular component	extracellular exosome
GO_0031674	Cellular component	I band
GO_0005829	Cellular component	cytosol
GO_0031430	Cellular component	M band
GO_0000794	Cellular component	condensed nuclear chromosome
GO_0019899	Molecular function	enzyme binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0106310	Molecular function	protein serine kinase activity
GO_0008307	Molecular function	structural constituent of muscle
GO_0019887	Molecular function	protein kinase regulator activity
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0097493	Molecular function	structural molecule activity conferring elasticity
GO_0019901	Molecular function	protein kinase binding
GO_0051015	Molecular function	actin filament binding
GO_0051371	Molecular function	muscle alpha-actinin binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0042802	Molecular function	identical protein binding
GO_0002020	Molecular function	protease binding
GO_0031433	Molecular function	telethonin binding
GO_0005524	Molecular function	ATP binding
GO_0042805	Molecular function	actinin binding
GO_0005516	Molecular function	calmodulin binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TTN
Protein name	Titin fetal Isoform Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) Transthyretin Titin
Synonyms
Description	FUNCTION: Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. .
Accessions	A0A0A0MRA3 ENST00000342992.11 [Q8WZ42-11] H7C195 ENST00000589042.5 ENST00000436599.1 ENST00000446966.1 ENST00000412264.1 ENST00000448510.2 ENST00000359218.10 [Q8WZ42-10] Q8WZ42 ENST00000591111.5 [Q8WZ42-1] B1A7R7 ENST00000460472.6 [Q8WZ42-3] ENST00000414766.5 A0A7R6RQ48 H0Y4J7 H7C0U7 C0JYZ2 ENST00000425332.2 H7C1P9 A0A0C4DG59 ENST00000342175.11 A0A0U1RRH3 Q71S18 ENST00000634225.1 A0A0A0MTS7 Q8WZ50 ENST00000360870.10 [Q8WZ42-6] A0A1B0GXE3 C9JQJ2 ENST00000426232.5

TTN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review